Board Review Questions
Last revised 5 November 2008
Copyright © 2008, PathologyOutlines.com, Inc.
General Surgical Pathology
1. What lymphomas are common in the stomach?
A) Follicular Lymphoma and T cell lymphoma
B) Diffuse Large B Cell Lymphoma and MALT lymphoma
C) Hodgkin’s Lymphoma and Burkitt’s lymphoma
D) Lymphoplasmacytic Lymphoma and Anaplastic lymphoma
Answer: Diffuse Large B Cell Lymphoma and MALT lymphoma
Source: Ann Oncol 2008 Jul 22 [Epub ahead of print], also Stomach chapter of PathologyOutlines.com
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
2. What is the most common hereditary kidney abnormality?
A) Autosomal dominant polycystic kidney disease
B) Autosomal recessive polycystic kidney disease
C) Renal manifestions of tuberous sclerosis
D) Caroli's syndrome
Answer: Autosomal dominant polycystic kidney disease. It primarily affects adults, and has an incidence of 1-2 per 1000 live births, compared to 1 per 6,000 to 20,000 live births for autosomal recessive polycystic kidney disease, 1 per 10,000 for tuberous sclerosis (with or without renal disease, Neurology 1985;35:600) and 1 per 1,000,000 for Caroli’s disease, which primarily affects the intrahepatic bile ducts (eMedicine)
Source: Rosai (9th edition), page 959, Kidney tumor chapter of PathologyOutlines.com
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
3. Tuberous sclerosis is associated with all of the following tumors except:
A) Clear cell sarcoma of soft parts
B) Angiomyolipoma of the kidney
C) Lymphangiomyomatosis of the lung
D) Cortical tuber of the brain
Answer: Clear cell sarcoma of soft parts. Tuberous sclerosis is caused by mutations in the TSC1 or TSC2 genes, although many cases are sporadic. It is associated with tubers of the brain cortex and lymphangiomyomatosis of the lung. It is also associated with renal angiomyolipoma and renal clear cell carcinoma, but not with renal clear cell sarcoma of soft parts, which is due to the t(12;22)(q13;q12) translocation.
Source: Kidney tumor chapter of PathologyOutlines.com
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
Transfusion Medicine
1. What is the shelf life of platelets?
A) 5 days
B) 6 days
C) 7 days
D) 8 days
E) 10 days
Answer: 5 days
Source: AABB Technical Manual
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
2. How soon must a full written report regarding a transfusion related death be submitted to the FDA?
A) 24 hours
B) Five business days
C) Seven business days
D) Seven days
E) One month
Answer: Seven Days
Source: AABB Technical Manual and FDA website - http://www.fda.gov/cber/transfusion.htm
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
3. What are Howell-Jolly bodies composed of?
A) RNA
B) DNA
C) Ribosomes
D) Keratin
E) All of the above
Answer: DNA
Source: Robbins (7th ed); image
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
4. What are Pappenheimer bodies composed of?
A) RNA
B) DNA
C) Microtubules
D) Iron
E) Keratin
Answer: Iron
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
5. Hereditary hemochromatosis is inherited in what pattern and physiologic disruption:
A) Autosomal Dominant, inability to excrete iron adequately
B) Autosomal Recessive, inability to excrete iron adequately
C) Autosomal Dominant, excess iron absorption
D) Autosomal Recessive, excess iron absorption
E) Mitochondrial, inability to excrete iron adequately
Answer: Autosomal Recessive, excess iron absorption
Source: PathologyOutlines.com-Liver nontumor chapter, also Foundations in Diagnostic Pathology: Gastrointestinal and Liver Pathology, page 503
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
6. What is the most common mutation for hereditary hemochromatosis?
A) S65C
B) H63D
C) C282Y
D) H85Y
E) HFE
Answer: C282Y
Source: PathologyOutlines.com-Liver nontumor chapter, also Foundations in Diagnostic Pathology: Gastrointestinal and Liver Pathology, page 503. Up to 85% of clinically recognized cases in Northern and Western Europeans are homozygotes for the C282Y mutation, a missense mutation. S65C and H63D are other HH mutations but are not the most common. HFE is the gene located on chromosome 6p.
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
7. What is the most common genetic disorder in Caucasians?
A) Cystic fibrosis
B) Hereditary hemochromatosis
C) Tuberous sclerosis
D) Sickle Cell Anemia
E) Tay Sachs
Answer: Hereditary hemochromatosis
Source: PathologyOutlines.com-Liver nontumor chapter, also Foundations in Diagnostic Pathology: Gastrointestinal and Liver Pathology, page 503; also http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/hh.shtml
Prevalence in homozygous state is 1 in 200 whites with carrier frequency between 1 in 10 and 1 in 20.
Contributor: Crystal L. Rose MD, MS, Ball Memorial Hospital, Indiana
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