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Hematopathology topic template at

Revised: 30 October 2019
Copyright: 2019,, Inc.

    Example of well written Hematopathology topic: Lymphoma and plasma cell neoplasms - High grade B cell lymphoma with MYC and BCL2 or BCL6 rearrangements.

    For ease of use, we put topic headings in the same order. Please put some text under each heading, but do not include obvious or repetitive information. If you think there is nothing to add, please write "not relevant to this topic", "repetitive with __ heading" or "unknown at this time" [i.e. if etiology is not known]. Do not delete any topic headings.

    A 1-2 sentence summary of the topic.

    Essential features
    This topic heading should be completed after the rest of the topic is finished, and should duplicate the 3-5 most important points mentioned elsewhere in the topic. In other words, it should list what every pathologist should know about the topic, or what would be in a Board Review book.

    Other names used today or historically that pathologists may be more familiar with.

    ICD coding
    Include relevant ICD-10, ICD-11 and ICD-0 codes with associated diagnoses.

    Who gets this lesion - age, gender, geographic location, very strong causal connections (example: Kaposi sarcoma and HIV, HHV8); weaker associations are listed under clinical features).

    Parts of the body or organ typically affected.

    Step by step details of how the lesion / tumor arises (if not obvious).

    Causes of the lesion (e.g. smoking).

    Those that don't automatically fit in another section. Provide caption and figure legend.

    Clinical features
    Anything clinical not included above or below. Includes associations with other conditions.

    Information on how a diagnosis is made including imaging modalities and procedures utilized. Do not include microscopic findings.

    Typical findings (positive or negative).

    Radiology description
    Typical findings (positive or negative).

    Radiology images
    Typical findings. Provide caption and figure legend for each image.

    Prognostic factors
    Favorable or unfavorable prognostic factors for a condition.

    Case reports
    Provide at least 5 quality case reports, most of which should be recent (within 5 years). The format is typically "25 year old man with coexisting zzz (reference)." We prefer references from free full text journals / websites, so pathologists can review the entire article. If there are numerous articles that can be cited, preferentially cite those in English over other languages.

    General modes of treatment. Drug dosages are usually not necessary - if you want to include them, please provide a reference.

    Clinical images
    This includes intraoperative images or images of the patient but NOT gross images. Provide caption and figure legend for each image.

    Gross description
    Description of the excised specimen.

    Gross images
    Images of the excised specimen with caption and figure legend for each image.

    Frozen section description
    Description of the features of tissue at frozen section, focusing on differences from the permanent section.

    Frozen section images
    Images of the specimen at frozen section with caption and figure legend for each image.

    Microscopic (histologic) description
    List microscopic diagnostic criteria first, if they exist. Then common and uncommon histologic features, associated features and microscopic grading criteria if applicable. Include classification systems here or under clinical features.

    Microscopic (histologic) images
    Author must take and submit high quality representative micro images with caption and figure legend for each image. Include low and high power H&E images and relevant immunostains and special stains. Bone marrow core biopsy and bone marrow clot are included in this section.

    Virtual slides
    See above for recommended websites. Provide a caption for each slide.

    Cytology description
    Cytologic features and limitations.

    Cytology images
    Cytology images with caption and figure legend for each image that include description of cytology findings and preparation, i.e. PAP, DiffQuick, cell block. Include bone marrow aspirates and touch preparations in this section.

    Peripheral smear description
    For hematopathology, or as relevant.

    Peripheral smear images
    Peripheral smear images with caption and figure legend for each image.

    Positive stains
    Include relevant IHC and special stains. List most commonly used first. If not uniformly positive, provide percentage of cases. List staining patterns if uncommon.

    Negative stains
    Include relevant IHC and special stains. List most commonly used first. If not uniformly negative, provide percentage of cases. List staining patterns if uncommon.

    Flow cytometry description
    Description of scatterplot images.

    Flow cytometry images
    Flow cytometry scatterplot images with caption and figure legend for each image.

    Electron microscopy description
    Electron microscopy diagnostic findings.

    Electron microscopy images
    Electron microscopy images with caption and figure legend for each image.

    Molecular / cytogenetics description
    Description of DNA / RNA findings based on testing via sequencing, PCR, FISH, CISH, ISH, cytogenetics, etc.

    Molecular / cytogenetics images
    Images of FISH, CISH, ISH, electropherograms, PCR gels, karyograms, etc. with caption and figure legend for each image.

    Links to YouTube or other sites. Provide caption for each video.

    Sample pathology report
    Provide an example of a typical diagnostic report for this diagnosis. Begin with a line that states the organ and procedure in the format "Organ, procedure:". On the following lines provide the diagnosis. Include all information that would be in a diagnosis except for the synoptic report. State "(see synoptic report)" at the end of the diagnosis line if a synoptic report would be included. If you would include a comment in your report, state "(see comment)" and on the next line include your comment with all content that you would write in your report. Refer to this example: Chronic myelomonocytic leukemia (very detailed report).

    Differential diagnosis
    List names of entities in order from most to least important. Include most important differentiating features that are present or absent in each diagnosis in the differential. We will link to the topic on our site.

    Additional references
    General references for this topic not included above.

    Board Review Question(s)
    Prepare 2 board review style questions that highlight important content from this topic. If the topic describes a very rare entity, 1 question testing basic information is sufficient. If the topic describes a very common entity, 3 questions testing basic information are suggested. These are not actual questions from the Pathology boards but review questions written in a similar format. The questions should test basic, essential diagnostic concepts that all pathologists should know rather than minor details. The topic needs to contain all information relevant to correct and incorrect answers. The first question must contain an image of the entity followed by a multiple choice question, such as "Which of the following is true about XXX tumor/disease?" The image can be reused from the topic. Do not use the format "Which of the following is false?" Questions should have only one answer. Do not use responses "all of the above", "none of the above", "A and C", etc. This question will be part of our Board Review page so the reader may not know the topic with which it is associated. Therefore you must make the organ clear in the question and the diagnosis clear in the answer. The second question may have an image associated with it but an image is not required. Click here for examples.

    Board Review Answer(s)
    Answers to the Question(s) above, sorted alphabetically by the first letter in the answer.