Page views in 2019: 203
Page views in 2020 to date: 139
Hematopathology topic template

Revised: 5 August 2020
Copyright: 2019-2020, PathologyOutlines.com, Inc.

    Example of well written Hematopathology topic: Lymphoma and plasma cell neoplasms - High grade B cell lymphoma with MYC and BCL2 or BCL6 rearrangements

    For ease of use, we put topic headings in the same order. Please put some text under each heading, but do not include obvious or repetitive information. If you think there is nothing to add, please write "not relevant to this topic", "repetitive with __ heading" or "unknown at this time" [i.e. if etiology is not known]. Do not delete any topic headings.


    Author 1

    Author name with degrees: ___________________________________________

    Author rank (M.D. candidate / Resident / Fellow / Instructor / Assistant, Associate or Full Professor): ___________________________________________

    Author leadership roles (maximum of 2) (ex: Director of Surgical Pathology, Vice Chair of Anatomic Pathology, Director of Cytopathology): ___________________________________________

    Author institution name: ___________________________________________

    Author institution city, state, zip code and country: ___________________________________________

    Author email address: ___________________________________________


    Author 2

    Author name with degrees: ___________________________________________

    Author rank (Assistant, Associate or Full Professor): ___________________________________________

    Author leadership roles (maximum of 2) (ex: Director of Surgical Pathology, Vice Chair of Anatomic Pathology, Director of Cytopathology): ___________________________________________

    Author institution name: ___________________________________________

    Author institution city, state, zip code and country: ___________________________________________

    Author email address: ___________________________________________



    Chapter name: ___________________________________________

    Section and subsection (in the Table of Contents): ___________________________________________

    Topic name:___________________________________________



    Definition / general
    A 1 - 2 sentence summary of the topic.

    • >


    Essential features
    This topic heading should be completed after the rest of the topic is finished, and should duplicate the 3 - 5 most important points mentioned elsewhere in the topic. In other words, it should list what every pathologist should know about the topic or what would be in a Board Review book.

    • >


    Terminology
    Other names used today or historically that pathologists may be more familiar with.

    • >


    ICD coding
    Include relevant ICD-10, ICD-11 and ICD-0 codes with associated diagnoses.

    • >


    Epidemiology
    Who gets this lesion - age, gender, geographic location, very strong causal connections (example: Kaposi sarcoma and HIV, HHV8); weaker associations are listed under clinical features).

    • >


    Sites
    Parts of the body or organ typically affected.

    • >


    Pathophysiology
    Step by step details of how the lesion / tumor arises (if not obvious).

    • >


    Etiology
    Causes of the lesion (e.g. smoking).

    • >


    Diagrams
    Those that don't automatically fit in another section. Provide caption and figure legend.


    Clinical features
    Anything clinical not included above or below. Includes associations with other conditions.

    • >


    Diagnosis
    Information on how a diagnosis is made including imaging modalities and procedures utilized. Do not include microscopic findings.

    • >


    Laboratory
    Typical findings (positive or negative).

    • >


    Radiology description (optional)
    Typical findings (positive or negative).

    • >


    Radiology images (optional)
    Typical findings. For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened. If you do not have your own images, refer to the Case reports section for how to provide links to journal images, and provide links with a brief 1 - 4 word caption.


    Prognostic factors
    Favorable or unfavorable prognostic factors for a condition. Overall prognosis, recurrence rates, etc.

    • >


    Case reports
    List 3 - 5 quality case reports, preferably from the past 5 years (unless the diagnosis is exceedingly rare). The format should be written as "25 year old man with large retroperitoneal mass (PMID: XXXX)." We prefer case reports from free full text PubMed archived journals in English. To find case reports that meet this criteria, use the following PubMed search (fill in the diagnosis): DIAGNOSIS case reports[PT] free full text[SB] 2015:2020[DP] english[LA]. This search should also be utilized to find images that you are not able to provide, such as radiology, clinical, gross, cytology, electron microscopy and molecular / cytogenetics.

    • >


    Treatment
    General modes of treatment. Drug dosages are usually not necessary - if you want to include them, please provide a reference.

    • >


    Clinical images
    This includes intraoperative images or images of the patient but NOT gross images. For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened. If you do not have your own images, refer to the Case reports section for how to provide links to journal images, and provide links with a brief 1 - 4 word caption.


    Gross description
    Description of the excised specimen.

    • >


    Gross images
    Images of the excised specimen. For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened. If you do not have your own images, refer to the Case reports section for how to provide links to journal images, and provide links with a brief 1 - 4 word caption.


    Frozen section description
    Description of the tissue at frozen section, focusing on features relevant to the intraoperative differential diagnosis.

    • >


    Frozen section images
    Images of the specimen at frozen section. Touch preparations and smears should not be in this section (include in cytology images). For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened.


    Microscopic (histologic) description
    List microscopic diagnostic criteria first, if they exist. Then common and uncommon histologic features, associated features and microscopic grading criteria if applicable. Include classification systems here or under clinical features.

    • >


    Microscopic (histologic) images
    The author must take and submit high quality representative micro images. Include low and high power H&E images and relevant immunostains and special stains. Bone marrow core biopsy and bone marrow clot are included in this section. For each image, submit both a caption and a figure legend in the manuscript word document. Do not include your name, twitter handle, institution or logo on the image. The caption will appear below the thumbnail of the image and should be 1 - 4 words describing the image findings, such as "cytologic atypia", "chronic inflammation", "epithelioid cells", "chromogranin" or "AE1 / AE3". Do not use captions such as "Case 1", "Various images", "H&E", "100x" or the diagnosis. The figure legend will appear when the image is open and must contain all relevant information including site, procedure, diagnosis, key histologic findings and stain if other than H&E. Do not use figure legends such as "Case 1" or "Representative images". We will remove all existing outside micro images.


    Virtual slides
    Please check these sites: University of Toronto, University of Michigan. Provide a brief 1 - 4 word caption for each slide. If no virtual slides found, please advise. Please limit slides to 6 per topic and only include the most relevant / representative slides.


    Cytology description
    Cytologic features and limitations.

    • >


    Cytology images
    Cytology images, if clinically appropriate. For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened. If you do not have your own images, refer to the Case reports section for how to provide links to journal images, and provide links with a brief 1 - 4 word caption. Include preparation, i.e. Pap, Diff-Quik, cell block, H&E touch, H&E smear. Include bone marrow aspirates and touch preparations in this section. Contact us if you need help obtaining images.


    Peripheral smear description
    For hematopathology, or as relevant.

    • >


    Peripheral smear images
    Peripheral smear images with caption and figure legend for each image.


    Positive stains
    Provide a list of the names of relevant IHC and special stains that are positive at least 50% of the time. Stains that are predominantly negative should go in the negative stains section. Begin each bullet with the name(s) of the stain(s). List those most commonly used first. If not uniformly positive, provide percentage of cases. List staining patterns if uncommon.

    • >


    Negative stains
    Include relevant IHC and special stains. List most commonly used first. If not uniformly negative, provide percentage of cases. List staining patterns if uncommon.

    • >


    Flow cytometry description
    Description of scatterplot images.

    • >


    Flow cytometry images
    Flow cytometry scatterplot images with caption and figure legend for each image.


    Electron microscopy description
    Electron microscopy diagnostic findings.

    • >


    Electron microscopy images
    Electron microscopy images. For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened. If you do not have your own images, refer to the Case reports section for how to provide links to journal images, and provide links with a brief 1 - 4 word caption.


    Molecular / cytogenetics description
    Description of DNA / RNA findings based on testing via sequencing, PCR, FISH, CISH, ISH, cytogenetics, etc.

    • >


    Molecular / cytogenetics images
    Images of FISH, CISH, ISH, electropherograms, PCR gels, karyograms, etc. For images you submit, provide a brief 1 - 4 word caption to appear below the thumbnail of the image and a longer figure legend to appear when the image is opened. If you do not have your own images, refer to the Case reports section for how to provide links to journal images, and provide links with a brief 1 - 4 word caption.


    Videos
    Links to YouTube or other sites or create your own (preferably 5 minutes or less). Provide a caption for each video. Dr. Gardner has many skin and soft tissue videos on his YouTube page.


    Sample pathology report
    Provide an example of a typical diagnostic report for this diagnosis. Begin with a line that states the organ and procedure in the format "Organ, procedure:". On the following lines provide the diagnosis. Include all information that would be in a diagnosis except for the synoptic report. State "(see synoptic report)" at the end of the diagnosis line if a synoptic report would be included. If you would include a comment in your report, state "(see comment)" and on the next line include your comment with all content that you would write in your report. Refer to this example: Chronic myelomonocytic leukemia (very detailed report).

    • >


    Differential diagnosis
    List names of entities in order from most to least important. Use short, concise bullets to include the most important differentiating features that are present or absent in the differential diagnosis entity, not the topic diagnosis. Do not describe features found in the topic diagnosis. We will link to the entity on our site.

    • >


    Additional references
    General references for this topic not included above.

    • >


    Board Review Question(s)
    Prepare 2 board review style questions that highlight important content from this topic. If the topic describes a very rare entity, 1 question testing basic information is sufficient. If the topic describes a very common entity, 3 questions testing basic information are suggested. These are not actual questions from the Pathology boards but review questions written in a similar format. The questions should test basic, essential diagnostic concepts that all pathologists should know rather than minor details. The topic needs to contain all information relevant to correct and incorrect answers. The first question must contain an image of the entity followed by a multiple choice question, such as "Which of the following is true about XXX tumor/disease?" The image can be reused from the topic. Do not use the format "Which of the following is false?" Questions should have only one answer. Do not use responses "all of the above", "none of the above", "A and C", etc. This question will be part of our Board Review page so the reader will not know the topic with which it is associated. Therefore you must make the organ clear in the question and the diagnosis clear in the answer. The second question may have an image associated with it but an image is not required. Click here for examples.


    Board Review Answer(s)
    Answers to the Question(s) above, sorted alphabetically by the first letter in the answer.