Bone Marrow - nonneoplastic

Authors/Editors: Dragos Luca, M.D., Xiangrong (Alex) Zhao, M.D., Ph.D. (see Authors page)

Revised: 27 August 2015, UPDATE IN PROGRESS

Copyright: (c) 2001-2015, PathologyOutlines.com, Inc.

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Table of contents

Primary referencesembryonic developmentbiopsy techniquereportingroutine stains

Normal: bone marrow-generalbasophilseosinophilserythroid maturationhematogoneslymphocyte maturationmast cellsmegakaryocyte maturationmonocyte maturationneutrophil maturationosteoblastsosteoclastsplasma cellsage related changes

Alterations in cellularity: cellularity-generalamegakaryocytic thrombocytopeniaaplastic anemiaDiamond-Blackfan anemiadyskeratosis congenitaFanconi anemiahypercellularpure red cell aplasiaShwachman-Diamond syndromeTAR syndrometreatment related

Benign changes: arsenic toxicitygelatinous transformationHowell-Jolly bodiesironlymphoid aggregatesmegaloblastic anemianecrosispersistent polyclonal lymphocytosisplasmacytosispolymorphous reactive lymphoid hyperplasiasystemic polyclonal B immunoblastic proliferation

Infectious / inflammatory: CandidaCMVCryptococcusDengue fevergranulomatous inflammationhistoplasmosisHIV/AIDShuman granulocytic anaplasmosisLeishmaniamalariamycobacteriaparvovirus B19Penicilliosis marneffeiQ feversarcoidosisWhipple disease

Systemic disorders: alcohol abusebone marrow transplanationcalcium oxalateChediak-Higashi syndromecopper deficiencycystinosisFabry diseaseGaucher diseasemucopolysaccharidosis type VIINiemann-Pick diseasePearson syndromepodophyllinsea-blue histiocytosissickle cell


Index (table of contents in alphabetical order):

A-E: age related changesalcohol abuseamegakaryocytic thrombocytopeniaaplastic anemiaarsenic toxicitybasophilsbiopsy techniquebone marrow-generalbone marrow transplanationcalcium oxalateCandidacellularity-generalChediak-Higashi syndromeCMVcopper deficiencyCryptococcuscystinosisDenge feverDiamond-Blackfan anemiadyskeratosis congenitaembryonic developmenteosinophilserythroid maturation

F-M: Fabry diseaseFanconi anemiaGaucher diseasegelatinous transformationgranulomatous inflammationhematogoneshistoplasmosisHIV/AIDSHowell-Jolly bodieshuman granulocytic anaplasmosishypercellularironlymphoid aggregatesLeishmanialymphocyte maturationmalariamast cellsmegakaryocyte maturationmegaloblastic anemiamonocyte maturationmucopolysaccharidosis type VIImycobacteria

N-Z: necrosisneutrophil maturationNiemann-Pick diseaseosteoblastsosteoclastsparvovirus B19Pearson syndromePenicilliosis marneffeipersistent polyclonal lymphocytosisplasma cellsplasmacytosispodophyllinpolymorphous reactive lymphoid hyperplasiaprimary referencespure red cell aplasiaQ feverreportingroutine stainssarcoidosisShwachman-Diamond syndromesea-blue histiocytosissickle cellsystemic polyclonal B immunoblastic proliferationTAR syndrometreatment relatedWhipple disease



Primary references
top

Brunning: Tumors of the Bone Marrow (AFIP Atlas of Tumor Pathology, Series 3, Vol 9; 1994)
Foucar: Bone Marrow Pathology (ASCP Press): 3rd ed. 2010,
also 2nd ed. 2001
Foucar: Non-Neoplastic Disorders of Bone Marrow, Atlas of Non-Tumor Pathology (AFIP/ARP, 2009)
Ioachim's Lymph Node Pathology (Lippincott Williams & Wilkins, 2008)
Penchansky: Pediatric Bone Marrow (Springer-Verlag, 2013)
Swerdlow: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (IARC, 2008)
Warnke:Tumors of the Lymph Nodes and Spleen (Atlas of Tumor Pathology, 3rd Series, Vol. 14; 1995)
Wickramasinghe: Blood and Bone Marrow Pathology (Churchill Livingstone, 2003)

Websites with images: American Society of Hematology, PathoPic


Recent / Important Bone Marrow pathology books
 

Aster: 2013

Brunning: 1994

Foucar: 2010

Foucar: 2009

Gatter: 2014

Jaffe: 2010

Naeim: 2013

Orazi: 2013

Penchansky: 2013

Swerdlow: 2008


Click here for other Bone Marrow / Hematopathology books