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Breast malignant, males, children
Reviewers: Dina Kandil, M.D., Monika Roychowdhury, M.D., Daniel Visscher, M.D. (see Reviewers page)
Revised: 13 December 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
In situ carcinoma: DCIS - general apocrine basal-like clinging comedo cribriform cystic hypersecretory micropapillary mucinous neuroendocrine papillary signet ring cell solid solid papillary spindle cell squamous cell / Bowen’s disease
LCIS - classic pleomorphic
other - ductal intraepithelial
neoplasia (DIN) mammary intraepithelial neoplasia Paget’s disease
Breast cancer: general axillary nodes EGFR, HER2 histologic grading,
hormone receptors microinvasive pregnancy risk factors sentinel nodes spread/metastases suspicious WHO classification
prognostic factors: general angiolymphatic
invasion fibrotic focus multigene products
Carcinoma subtypes:
ductal NOS and variants: general choriocarcinomatous melanotic mixed osteoclastic giant cells pleomorphic
lobular carcinoma and variants: classic alveolar basal-like histiocytoid pleomorphic signet-ring solid trabecular
metaplastic carcinoma and subtypes: general fibromatosis-like matrix producing spindle cell
neuroendocrine carcinoma and variants: general solid large cell
general acinic cell adenoid cystic adenosquamous apocrine basal cell-nipple basal-like BRCA1 BRCA2 central acellular cribriform cystic hypersecretory glycogen rich inflammatory intracystic papillary intralymphatic lipid rich luminal lymphoepithelioma-like medullary metastases to breast micropapillary mixed ductal and lobular mucin-producing mucinous mucinous
cystadenocarcinoma mucoepidermoid myoepithelial oncocytic papillary sebaceous secretory signet ring small cell squamous cell squamous cell-acantholytic tall-cell like tubular tubulolobular
Sarcoma: general angiosarcoma leiomyosarcoma liposarcoma low grade myofibroblastic
sarcoma MFH MPNST osteosarcoma rhabdomyosarcoma sarcoma NOS stromal sarcoma
Other malignancies: lymphoma myeloid sarcoma plasmacytoma Rosai-Dorfman
Childhood tumors: general juvenile fibroadenoma juvenile papillomatosis carcinoma
Male tumors: general gynecomastia myofibroblastoma papilloma carcinoma metastases
Miscellaneous:
treatment effect - chemotherapy cryoprobe hormone therapy radiation therapy
frozen sections grossing features to report staging
Superpages: in situ carcinoma breast cancer-general carcinoma subtypes other entities
Index (table of contents in alphabetical order)
A-E: acinic cell carcinoma adenoid cystic carcinoma adenosquamous carcinoma angiolymphatic
invasion angiosarcoma apocrine carcinoma axillary nodes basal cell carcinoma-nipple basal-like carcinoma BRCA1 carcinoma BRCA2 carcinoma breast cancer-general carcinoma subtypes-general central acellular carcinoma childhood carcinoma childhood tumors choriocarcinomatous cribriform carcinoma cystic hypersecretory carcinoma DCIS-apocrine DCIS-basal-like DCIS-clinging DCIS-comedo DCIS-cribriform DCIS-cystic hypersecretory DCIS-general DCIS-micropapillary DCIS-mucinous DCIS-neuroendocrine DCIS-papillary DCIS-signet ring cell DCIS-solid DCIS-solid papillary DCIS-spindle cell DCIS-squamous cell / Bowen’s disease ductal intraepithelial neoplasia (DIN) ductal NOS-general ductal NOS-mixed ductal NOS-pleomorphic EGFR
F-N: features to report fibrotic focus frozen sections glycogen rich carcinoma grossing gynecomastia HER2 histologic grading,
hormone receptors inflammatory carcinoma intracystic papillary carcinoma intralymphatic carcinoma juvenile fibroadenoma juvenile papillomatosis LCIS-classic LCIS-pleomorphic leiomyosarcoma lipid rich carcinoma liposarcoma lobular carcinoma-classic lobular carcinoma-alveolar lobular carcinoma-basal-like lobular carcinoma-histiocytoid lobular carcinoma-pleomorphic lobular carcinoma-signet-ring lobular carcinoma-solid lobular carcinoma-trabecular low grade myofibroblastic
sarcoma luminal carcinoma lymphoepithelioma-like carcinoma lymphoma male tumors-carcinoma male tumors-general male tumors-metastases mammary intraepithelial neoplasia medullary carcinoma melanotic metaplastic carcinoma-general metaplastic carcinoma-fibromatosis-like metaplastic carcinoma-matrix producing metaplastic carcinoma-spindle cell metastases to breast carcinoma MFH microinvasive micropapillary carcinoma mixed ductal and lobular carcinoma MPNST mucin-producing carcinoma mucinous carcinoma mucinous
cystadenocarcinoma mucoepidermoid carcinoma multigene products myeloid sarcoma myoepithelial carcinoma myofibroblastoma neuroendocrine carcinoma-general neuroendocrine carcinoma-solid neuroendocrine carcinoma-large cell
O-Z: oncocytic carcinoma osteoclastic giant cells osteosarcoma Paget’s disease papillary carcinoma papilloma-males plasmacytoma pregnancy prognostic factors-general rhabdomyosarcoma risk factors Rosai-Dorfman sarcoma-general sarcoma NOS sebaceous carcinoma secretory carcinoma sentinel nodes signet ring carcinoma small cell carcinoma spread/metastases squamous cell carcinoma squamous cell carcinoma-acantholytic staging stromal sarcoma suspicious tall-cell like carcinoma treatment effect-chemotherapy treatment effect-cryoprobe treatment effect-hormone therapy treatment effect-radiation therapy tubular carcinoma tubulolobular carcinoma WHO classification
Go to Breast-nonmalignant chapter
Primary references
top
AJCC Cancer Staging Manual (7th ed)
American Journal of Clinical Pathology
American Journal of Surgical Pathology
Archives of Pathology and Laboratory Medicine
Human Pathology
Modern Pathology
Rosen:
Tumors of the Mammary Gland (AFIP Fascicle, 3rd series, volume 7); 1994
Tavassoli:
Tumours of the Breast and Female Genital Organs (WHO, 2003)
Virtual slides: USCAP vSlides
Websites: Digital Atlas of Breast Pathology National Institutes of Health Online Management of Breast Diseases PathoPic Webpathology.com
Please refer to these primary references for more detailed discussions and photographs
End of Breast-malignant, males, children chapter