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June 2011: Diagnostic testing / reagents

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Biocare Medical is an innovator in developing and supplying world-class immunohistochemistry and molecular pathology reagents and instrumentation. Biocare is the market leader in Simultaneous Multiplex IHC™, solving complex clinical problems such as differentiation of usual and atypical ductal hyperplasia in breast, squamous cell carcinoma from adenocarcinoma in lung, PIN in prostate and CIS in bladder. The intelliPATH FLX™ distinctively combines an open IHC system with continuous random access capabilities, allowing for complete workflow flexibility.  Biocare’s proprietary RISH™ technology simplifies in situ hybridization, bringing ISH to any laboratory.  SPOT-Light® HER2 CISH, the only FDA approved HER2 CISH test, provides the confidence and objectivity of in situ hybridization with the ease of IHC. We offer an expanding portfolio of integrated products for cancer and infectious disease diagnostics to hospitals, reference labs and research laboratories. Go to http://www.biocare.net, call customer service at 800-799-9499 or email contact@biocare.net for more information.

BioGenex Laboratories, Inc. is a leading developer, manufacturer and marketer of novel technologies for molecular diagnostics of cancers and infectious diseases. The company offers a broad range of reagents including over 500 primary antibodies and cocktails, DNA and microRNA probes, SuperSensitive™ IHC and ISH polymer single and double staining kits and consumables to deliver precise results, support accurate diagnosis and accelerate the pace of personalized medicine. Our state-of-the-art instrumentation, designed for high throughput and productivity at a low cost of ownership, includes the EZ-Retriever® for pre-treatment and antigen retrieval, semi-automated i6000™ staining system, and Fully Automated Xmatrx® - the world’s first and only complete automation for multiple applications of IHC, IF, ISH, FISH, in situ PCR, CTC and Multiplexing. Our technologies and products provide consistent, reliable and reproducible results with ease of use and maximum flexibility for clinical diagnostics, life science research and drug discovery worldwide. For more information call (800) 421-4149, email marketing@biogenex.com or visit us at www.biogenex.com.

Biotheranostics discovers and develops innovative diagnostic technologies for oncology, designed to improve patient care from the time of diagnosis through selection of appropriate treatment.  The company's initial diagnostic test offerings are: (1) THEROS CancerTYPE ID®, which improves cancer classification, especially in patients with metastatic cancer and an unknown primary.  It is based on a 92-gene qRT-PCR panel and capable of identifying up to 39 tumor types with 86% accuracy. (2) THEROS Breast Cancer Index® - This provides a more complete picture of recurrence risk and therapeutic options for patients by combining the results of the THEROS H/I and THEROS MGI tests, to better stratify ER-positive, node-negative breast cancer patients.bioTheranostics is also working on prostate cancer prognosis  and drug-response profiling.  Email Brittany.Rothnem@biotheranostics.com or call 858 587 5883 for more information.

Covance is a provider of gold standard Signet™ immunopathology antibodies, detection chemistries and ancillaries.  Monoclonal and polyclonal antibodies are offered for immunohistochemistry on formalin-fixed paraffin-embedded tissues and for a variety of other assays.  These antibodies are available in pre-diluted and concentrated formats, providing ease-of-use and reproducibility in both manual and automated staining.  Detection chemistries, chromogens, counterstains and buffers are also available in a range of kit volumes to meet your laboratory needs.  Covance’s antibody portfolio also includes antibodies for neurodegenerative disease, cell biology and a variety custom immunology services.  For more information contact Angela Thomas, Immunopathology Product Manager, at 800.223.0796 or angela.thomas@covance.com.  Visit our website at www.covance.com

Epitomics is the world leader in rabbit monoclonal antibody (RabMAb®) technology. Using our proprietary RabMAb technology, we have developed high quality antibodies (EP Clones™) and IHC kits (EpiPrecision™, EpiVision™) for anatomical pathology use.  With the benefits of RabMAb technology, EP Clones offers superior binding affinity and specificity. EP Clones have been specifically developed and optimized for use in pathology laboratories for immunohistochemical staining of formalin-fixed paraffin embedded tissues. We are committed to providing high quality products and services that consistently meet the needs of our customers. For more information contact us at 877-772-2622, IVDinfo@epitomics.com, or visit our website at www.epitomics.com/diagnostics.

Leica is a leading global developer and manufacturer of a broad range of innovative, high-tech, precision optical systems for the imaging, measurement, and analysis of microstructures.  Leica Microsystems is one of the market leaders in each of its four divisions: Life Science, Industry, Biosystems, and Surgical.  Business areas include Microscopy and Imaging Systems, Specimen Preparation, Medical Equipment, and Antibodies and Reagents.  The company offers instruments and system solutions for the entire histopathology process including the NovocastraTM range of antibodies and reagents, consumable products, and clinical microscopes.  The company is represented in over 100 countries with 9 manufacturing facilities in 7 countries, sales and service organizations in 20 countries and an international network of dealers.

Olive Tree Media LLC. OTMIAS® 2.0: OTMIAS® is an affordable, easy to use, stand-alone image analysis software for biomedical research. You may use your current microscope, digital microscope camera, and computer (see system requirements) with this software. OTMIAS® can be used for DNA ploidy cell cycle analysis, proliferative activity, apoptosis assay, and biomarkers analysis on sections of formalin-fixed and paraffin-embedded cells and tissues. Built in tests currently include DNA ploidy, S-phase fraction (proliferative), apoptosis, oxidative DNA damage, ER, PR, p53, Thymidylate synthase, Topoisomerase 2 alpha (TOP2A), Tumor necrosis factor alpha (TNF-alpha), Her2, EGFR, Glut1, and ASCT2. Custom services also available. Visit us at www.otmedia.com.

Ventana Medical is one of the world’s leading developers and manufacturers of medical diagnostic instrument and reagent systems providing leading-edge automation technology for use in slide-based diagnosis of cancer and infectious disease. Our products are found in hospital-based histology laboratories, independent reference laboratories, and the drug discovery laboratories of some of the world’s largest pharmaceutical and biotechnology companies, government labs, and medical research centers. For more information please visit our website at www.ventanamed.com  or call us at 800.227.2155.

Past / future feature pages:

February 2011: Microscopes / slide imaging
March 2011: Tissue processors / other histology
April 2011: Lab Accreditation/ Education
May 2011: Computer software and systems

July 2011: Imaging / digital / photography
August 2011: Books & Journals
September 2011: Antibodies
October 2011: Laboratories
November 2011: Consumable Lab Products
December 2011: Grossing workstations / lab furniture
January 2012: Billing / consulting / management
February 2012: Microscopes / slide imaging
March 2012: Tissue processors / other histology
April 2012: Lab Accreditation/ Education
May 2012: Computer software and systems

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