26 March 2009 – Case of the Week #141
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Thanks to Dr. Julia Braza, Beth Israel Deaconess Medical Center, Boston, Massachusetts (USA), for contributing this case. To contribute a Case of the Week, email NatPernick@Hotmail.com with the clinical history, your diagnosis and diagnostic microscopic images in JPG, GIF or TIFF format (send as attachments, we will shrink if necessary). Please include any other images (gross, immunostains, etc.) that may be helpful or interesting. We will write the discussion (unless you want to), list you as the contributor, and send you $35 (US dollars) by check or PayPal for your time after we send out the case. Please only send cases with high quality images and a diagnosis that is somewhat unusual (or a case with unusual features).
Case of the Week #141
A 42 year old woman presented with possible hepatic adenomas. A resected segment of liver measured 9 x 6 cm, and showed two additional well circumscribed lesions measuring 2.5 and 2 cm.
What is your diagnosis?
Nodules of focal fatty change
Focal fatty change was first described in 1980 (Gastroenterology 1980;78:247). It is rare, and often an incidental finding identified at autopsy or with imaging studies. Lesions may be up to 12 cm, be single or multiple, and may clinically simulate malignancy (Przegl Lek 2006;63:695). Microscopically, they consist of focal lipid deposits with preservation of the hepatic architecture.
The differential diagnosis includes other possible lipid-rich lesions, including angiomyolipoma, coelomic fat ectopia (Arch Pathol Lab Med 1985;109:783)
diffuse steatosis, focal nodular hyperplasia, hepatic adenoma, lipoma and myelolipoma. Fatty change has also been reported in hepatocellular carcinoma (AJR Am J Roentgenol 1988;151:717).
The cause of focal fatty change is unknown, but suggested possibilities include focal tissue hypoxia or local effects of insulin in a case of metastatic insulinoma to the liver (Pathol Int 2008;58:59) .
Nat Pernick, M.D., President
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