14 December 2005 – Case of the Week #31
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We thank Professor D. Y. Cohen, Department of Pathology, Herzliyah Medical Center, Israel, for contributing this case. We invite you to contribute a Case of the Week by sending an email to [email protected] with microscopic images (any size, we will shrink if necessary) in JPG or GIF format, a short clinical history, your diagnosis and any other images (gross, immunostains, EM, etc.) that you have and that may be helpful or interesting. We will write the discussion (unless you want to), list you as the contributor, and send you a check for $35 (US) for your time after we send out the case. Please only send cases with a definitive diagnosis.
Case of the Week #31
A 44 year old woman clinically had extensive tumor deposits on the omentum and serosal surfaces of the uterus, ovaries and Fallopian tubes. A total abdominal hysterectomy, bilateral salpingo-oophorectomy was performed.
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In all sites examined, the tumor was composed primarily of psammoma bodies with intervening areas of fibroblastic proliferation and small clusters of epithelial cells. Only mild to moderate atypia was present. Mitotic figures were absent or rare.
Psammocarcinoma, first reported in 1990 (Int J Gynecol Pathol 1990;9:110), is a rare variant of either peritoneal or ovarian serous carcinoma characterized by massive (75% or more) psammoma bodies. Cytologic features are low grade, and mitotic figures are absent or rare. Extraovarian tumor implants may be present, and the tumors are often stage III.
Treatment typically consists of maximal debulking with no chemotherapy or radiation therapy (Gynecol Oncol 1999;73:331). In young women, conservative surgery may be an option (Gynecol Oncol 1999;73:312)
The behavior of psammocarcinoma is indolent, and more closely resembles serous borderline tumors than serous carcinomas. However, a case of aggressive disease with diffuse recurrence has been reported (Obstet Gynecol 1998;92(4 Pt 2):659)
Additional references: Am J Surg Pathol 1998;22:849
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