13 September 2006 – Case of the Week #59
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We thank Dr. Jamie Shutter, George Washington University, Washington D.C. (USA) for contributing this case. We invite you to contribute a Case of the Week by sending an email to [email protected] with microscopic images (any size, we will shrink if necessary) in JPG or GIF format, a short clinical history, your diagnosis and any other images (gross, immunostains, EM, etc.) that may be helpful or interesting. We will write the discussion (unless you want to), list you as the contributor, and send you a check for $35 (US) for your time after we send out the case. Please only send cases with a definitive diagnosis.
The next case (Case #60) will be sent on September 27, 2006, as we will be at the IAP in Montreal next week.
Case of the Week #59
A seven year old girl presented with precocious puberty. Pelvic ultrasound revealed a left ovarian mass.
What is your diagnosis?
(scroll down to continue)
Juvenile granulosa cell tumor
This tumor is composed of macrofollicles with eosinophilic secretions, and intervening tumor cells with abundant eosinophilic cytoplasm, round/oval hyperchromatic nuclei with small nucleoli, and mildly irregular nuclear contours. There are rare nuclear grooves. Other features often present include high mitotic activity, nuclear atypia and occasionally hobnail-like cells.
Grossly, these tumors are partially solid and cystic. Hemorrhage or necrosis may be present.
Juvenile granulosa cell tumors comprise only 5% of ovarian tumors of childhood or adolescence. Typically, they present as sexual precocity in prepubertal girls due to excessive estrogen production, although androgens may rarely be produced (J Endocrinol Invest 2006;29:653). Rarely, they are associated with an abnormal karyotype and ambiguous genitalia (AJSP 1985;9:737). Older patients may present with nonspecific abdominal swelling and pain.
Positive immunostains include inhibin and calretinin. They are not usually needed for diagnosis, but may be helpful in excluding germ cell tumors or melanoma.
The differential diagnosis includes adult granulosa cell tumors, thecoma and occasionally clear cell carcinoma. Adult granulosa cell tumors have more regularly shaped follicles that contain basement membrane material. Tumor cells have prominent nuclear grooves and less hyperchromasia.
Thecomas almost never occur in patients 30 years or younger, and usually lack mitotic activity. They also lack follicles, which are usually found in juvenile granulosa cell tumors with thorough sampling.
Finally, although hobnail-type cells may be seen in juvenile granulosa cell tumors, they are typically focal. In addition, patients with clear cell carcinoma are typically older, and their tumors lack follicles or areas of typical juvenile granulosa type cells.
Excision is usually adequate therapy for limited disease, although late recurrence may occur (Am J Obstet Gynecol 2004;191:366)
Additional references: Am J Surg Pathol 1984;8:575
Nat Pernick, M.D.
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