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22 February 2012 - Case of the Week #234
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Thanks to Dr. David Cohen, Herzliyah Medical Center (Israel), for contributing this case. To contribute a Case of the Week, follow the guidelines on our Case of the Week page.
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Case of the Week #234
A 29 year old woman had a cholecystectomy (no other clinical information provided).
What is your diagnosis?
Mild, chronic cholecystitis with a focus of metaplastic bone formation in the gallbladder mucosa
Metaplastic bone formation in the gallbladder mucosa is rare (South Med J 2009;102;322), and may clinically simulate cholelithiasis.
Osseous metaplasia is nonspecific. It may be associated with chronic cholecystitis, a cholesterol polyp (South Med J 2009;102:773), a fasciitis-like fibrous proliferation containing scattered osteoclast-like giant cells (Pediatr Dev Pathol 2011;14:80), or with carcinoma (Tumori 1999;85:133). In addition, osteosarcoma must be ruled out (HPB (Oxford) 2006;8:65).
Nat Pernick, M.D., President
and Liz Parker, B.A., Associate Medical Editor
30100 Telegraph Road, Suite 408
Bingham Farms, Michigan (USA) 48025
Alternate email: NatPernick@gmail.com