Cervix-Cytology

Authors: Ryan Askeland M.D., Zubair W. Baloch M.D. Ph.D., Farnaz Hasteh M.D., Ricardo R. Lastra M.D., Varsha Manucha M.D., Nat Pernick M.D., John KSS Philip M.D., Marilin Rosa M.D., Ziyan T. Salih M.D., Ashwyna Sunassee M.D., Xinmin Zhang M.D. (see Authors page)

Revised: 21 August 2015, last major update - in progress

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Table of contents

General: primary referencesgeneralPapliquid basedDiff-QuikBethesda system

Competency assessment: overviewnormal cytologybenign cellular changesorganismseffects of therapeutic agentspregnancymisc non-neoplasticepithelial cell abnormalitiesglandular cell abnormalitiesHPVPap test screening guidelinesPap test management guidelinesliquid-based PapBethesda systempractice monitors

Normal / benign / non-neoplastic: benign features-generaladenomyomaadenosisair drying artifactArias-Stella reactionatrophyatypical polypoid adenomyomaBarr bodyblue blobsciliacornflakesdecidual reactiondegenerationendocervical cellsendocervical polypendometrial cellsendometrial polypendometriosisendosalpingiosis / tubal metaplasiaeosinophilsexodusflorid ectopyhistiocyteshyperkeratosisinsect partsintermediate squamous cellsleiomyomalobular endocervical hyperplasialower uterine segment endometriumlubricantlymphocytesmale cellsmaturation indexmesonephric hyperplasiamesonephric remnantsmicroglandular hyperplasianavicular cellsneutrophilsparabasal cellsparakeratosisPM cellspost-hysterectomypsammoma bodiesrepairsmall blue cellssquamous cellssquamous metaplasiasquamous papillomasyncytiumtransitional metaplasiatumor diathesisunsatisfactory specimen

Inflammation / parasites: actinomycosisbacterial vaginosisCandidachlamydiachronic cervicitisCMVEnterobiusgranuloma inguinalegranulomasherpes/HSVLactobacillusLeptothrixSchistosomiasissyphilisTrichomonastuberculosisWucheria

Atypia / Premalignant / preinvasive lesions: adenocarcinoma in situ (AIS)atypical glandular cells (AGC)atypical repairatypical reserve cell hyperplasiaatypical squamous cells (ASC)chemotherapy effectcondylomaHPVHSIL/CIN IIHSIL/CINIIILSIL/CIN IPaget's diseaseradiation atypiaSIL-general

Carcinoma: adenocarcinomaadenocarcinoma-microinvasiveadenoid basaladenoid cysticadenosquamousclear cellendometrialglassy celllymphoepithelioma-likemetastases to cervixminimal deviation adenocarcinomaserous papillary adenocarcinomasignet ring cellsmall cellsquamous cell carcinomasquamous cell-microinvasiveurothelialverrucousvilloglandular papillary adenocarcinomawarty

Sarcoma / lymphoma / other: sarcoma-generalgranulocytic sarcomaleiomyosarcomalymphomamalignant mixed mullerian tumor (MMMT)melanomaplasmacytomarhabdomyosarcomastromal sarcoma


Alphabetical table of contents

A-E: actinomycosisadenocarcinomaadenocarcinoma in situ (AIS)adenocarcinoma-microinvasiveadenoid basaladenoid cysticadenomyomaadenosisadenosquamousair drying artifactArias-Stella reactionatrophyatypical glandular cells (AGC)atypical polypoid adenomyomaatypical repairatypical reserve cell hyperplasiaatypical squamous cells (ASC)bacterial vaginosisBarr bodybenign features-generalBethesda systemblue blobsCandidachemotherapy effectchlamydiachronic cervicitisciliaclear cellCMVcondylomacornflakesdecidual reactiondegenerationDiff-Quikendocervical cellsendocervical polypendometrial adenocarcinomaendometrial cellsendometrial polypendometriosisendosalpingiosis / tubal metaplasiaEnterobiuseosinophilsexodus

F-N: florid ectopygeneralglassy cell carcinomagranulocytic sarcomagranuloma inguinalegranulomasherpes/HSVhistiocytesHPVHSIL/CIN IIHSIL/CINIIIhyperkeratosisinsect partsintermediate squamous cellsLactobacillusleiomyomaleiomyosarcomaLeptothrixliquid basedlobular endocervical hyperplasialower uterine segment endometriumLSIL/CIN Ilubricantlymphocyteslymphoepithelioma-like carcinomalymphomamale cellsmalignant mixed mullerian tumor (MMMT)maturation indexmelanomamesonephric hyperplasiamesonephric remnantsmetastases to cervixmicroglandular hyperplasiaminimal deviation adenocarcinomanavicular cellsneutrophils

O-Z: Paget's diseasePapparabasal cellsparakeratosisplasmacytomaPM cellspost-hysterectomypsammoma bodiesradiation atypiarepairrhabdomyosarcomasarcoma-generalSchistosomiasisserous papillary adenocarcinomasignet ring cell carcinomaSIL-generalsmall blue cellssmall cell carcinomasquamous cell carcinomasquamous cell carcinoma-microinvasivesquamous cellssquamous metaplasiasquamous papillomastromal sarcomasyncytiumsyphilistransitional metaplasiaTrichomonastuberculosistumor diathesisunsatisfactory specimenurothelial carcinomaverrucous carcinomavilloglandular papillary adenocarcinomawarty carcinomaWucheria

Go to Cervix chapter

Primary references
top

DeMay: The Pap Test: Exfoliative Gynecologic Cytology (2nd Ed); ASCP, 2011
Solomon: The Bethesda System for Reporting Cervical Cytology (2nd Ed); Springer, 2005
Websites: Cytopathology of the Uterine Cervix-Digital AtlasNational Cancer Institute-American Society of Cytopathology AtlasJohns Hopkins Cytopathology Tutorial



Recent Cervix cytology / Gynecologic / Cytopathology books

Chhieng: 2010

Clement: 2013

Dallenbach-Hellweg: 2010

DeMay: 2011

Gill: 2012

Gray: 2010

Khalbuss: 2013

Khalbuss: 2013

Kini: 2011

Kocjan: 2013

McCluggage: 2015

Sheaff: 2012

Wilbur: 2008



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