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Diagnostic Testing / Reagents
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Diagnostic Agents in Personalized Medicine: The Era of Pharmacogenomics
Jaleh Mansouri, M.D.
Advancements in molecular biology and molecular techniques have propelled the
era of personalized medicine, especially in the field of pharmacogenomics and
therapeutics. For example, various genetic polymorphisms underlying the hepatic P450
(CYP) cytochrome system affect how people metabolize certain drugs, such as
antipsychotics and cardiovascular drugs including warfarin. This principle applies to
oncologic therapeutics as well where specific genetic mutations may determine whether a
patient responds to a certain chemotherapeutic regimen (eg, ALK in non-small cell lung
cancer, KRAS in colorectal cancer). These variances have prompted the development of
pharmacogenomic assays using specialized diagnostic reagents to optimize care in
choosing the most appropriate drug for treating disease in a particular patient.
Multiplex assays are often used to test pharmacogenomics profiles. One example
is the Luminex xTAG® Technology. This system utilizes specially dyed microspheres
with attached oligonucleotides (TAG) for coupling with the analyte target of interest.
The critical step of hybridization is carried out under optimal conditions to minimize
cross-contamination. The beads are separated by fluorometric methods. In this way
multiple reactions / samples can be analyzed using one assay to test an array of nucleic
acids. Similar assays have also been adapted to test for multiple proteins.
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Ventana Medical is one of the world's leading developers and manufacturers of medical diagnostic instrument and reagent systems providing leading-edge automation technology for use in slide-based diagnosis of cancer and infectious disease. Our products are found in hospital-based histology laboratories, independent reference laboratories, and the drug discovery laboratories of some of the world's largest pharmaceutical and biotechnology companies, government labs, and medical research centers. For more information please visit our website at www.ventanamed.com or call us at 800.227.2155.
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