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June 2015
Diagnostic Testing / Reagents


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Diagnostic Agents in Personalized Medicine: The Era of Pharmacogenomics
Jaleh Mansouri, M.D.


Advancements in molecular biology and molecular techniques have propelled the era of personalized medicine, especially in the field of pharmacogenomics and therapeutics. For example, various genetic polymorphisms underlying the hepatic P450 (CYP) cytochrome system affect how people metabolize certain drugs, such as antipsychotics and cardiovascular drugs including warfarin. This principle applies to oncologic therapeutics as well where specific genetic mutations may determine whether a patient responds to a certain chemotherapeutic regimen (eg, ALK in non-small cell lung cancer, KRAS in colorectal cancer). These variances have prompted the development of pharmacogenomic assays using specialized diagnostic reagents to optimize care in choosing the most appropriate drug for treating disease in a particular patient.

Multiplex assays are often used to test pharmacogenomics profiles. One example is the Luminex xTAG® Technology. This system utilizes specially dyed microspheres with attached oligonucleotides (TAG) for coupling with the analyte target of interest. The critical step of hybridization is carried out under optimal conditions to minimize cross-contamination. The beads are separated by fluorometric methods. In this way multiple reactions / samples can be analyzed using one assay to test an array of nucleic acids. Similar assays have also been adapted to test for multiple proteins.


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Advanced Cell Diagnostics, Inc. (ACD) is a leader in the emerging field of molecular pathology. The company's products and services are based on its proprietary RNAscope® technology, the first multiplex fluorescent and chromogenic in situ hybridization platform capable of detecting and quantifying RNA biomarkers in situ at single-molecule sensitivity. ACD partners with pharmaceutical and biotechnology companies to validate biomarkers and to develop companion diagnostic tests for targeted therapeutic development in cancer and other diseases. ACD also pursues internal programs to develop proprietary diagnostic tests in cancer management. For more information please contact info@acdbio.com or call 1-877-576-3636. Learn more at www.acdbio.com.

Ventana Medical is one of the world's leading developers and manufacturers of medical diagnostic instrument and reagent systems providing leading-edge automation technology for use in slide-based diagnosis of cancer and infectious disease. Our products are found in hospital-based histology laboratories, independent reference laboratories, and the drug discovery laboratories of some of the world's largest pharmaceutical and biotechnology companies, government labs, and medical research centers. For more information please visit our website at www.ventanamed.com or call us at 800.227.2155.


Past / Future Feature Pages:

February 2015: Microscopes / Microscopy Products
March 2015: Tissue Processors / Other Histology
April 2015: Laboratory Accreditation / Education / CME
May 2015: Computer Software and Systems
June 2015: Diagnostic Testing / Reagents

July 2015: Digital / Imaging / Photography
August 2015: Books & Journals
September 2015: Antibodies / Biomarkers
October 2015: Laboratories
November 2015: Consumable Lab Products / Clinical Lab Analyzers
December 2015: Grossing Equipment / Workstations

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