Feature Page
October 2015

Click here for the most recent Promotions page.

See the Laboratories product questionnaire page, for information about about laboratories who either perform specimen testing (molecular, immunohistochemistry, traditional reference laboratory testing) or to see second opinions on pathology slides / blocks. Any reference labs that our visitors work for can easily be added to the Product Questionnaires, by contacting contact Sara Halladay-Klakulak at 248/646-0325 or PathOutSales@gmail.com.

Anatomic Pathology Laboratory: Cross-Contamination of Tissue
Jaleh Mansouri, M.D.

Tissue cross-contamination remains an issue that every anatomic pathology laboratory must address in a systematic manner. While all types of specimens may be affected, misdiagnosis due to cross-contamination is more likely to impact biopsies and cytology specimens. Cross-contamination can occur at the grossing bench and during all stages of histologic tissue processing. This problem can be mitigated by frequently changing / filtering staining solutions and water in water baths as well as changing surgical blades (particularly after grossing malignant, infectious or friable tissue). The use of individual automated tissue stainers (e.g. Ventana, Leica) can further decrease the risk of tissue cross-contamination. Unfortunately, this risk cannot be entirely eliminated. Occasionally pathologists must resort to genetic testing (e.g. polymerase chain reaction or PCR) to rule out a "floater".

Bioinformatics may offer a new solution for handling tissue cross-contamination. For example, MicroArray Inspector (Transition Technologies) is a software program that detects contaminated tissue in microarrays by comparing expressed biomarkers of a tissue sample to its known biomarker profile. While this technology is still used only in limited research settings, one can easily imagine that computers may one day be routinely employed to confirm the genetic identity of every pathologic specimen and virtually eliminate the troublesome issue of tissue cross-contamination.

Contact Our Advertisers!

ARUP Laboratories. Founded in 1984, ARUP Laboratories is a leading national reference laboratory and an enterprise of the University of Utah and its Department of Pathology. ARUP offers more than 3,000 tests and test combinations, ranging from routine screening tests to esoteric molecular and genetic assays. ARUP serves clients across the United States, including many of the nation's top university teaching hospitals and children's hospitals, as well as multihospital groups, major commercial laboratories, military and other government facilities, and major clinics. In addition, ARUP is a worldwide leader in innovative laboratory research and development. For more information, visit www.aruplab.com.

Cleveland Clinic Laboratories has been providing the highest quality reference laboratory testing for more than 25 years. Today, our staff of board-certified anatomic and clinical pathologists, medical technologists and laboratory technicians provide crucial pathology and laboratory testing services to clients around the corner and across the country. Cleveland Clinic Laboratories operates 24 hours a day, seven days a week. Clients may select from a menu of more than 2,400 routine and esoteric tests. Through the application of leading-edge technology, Cleveland Clinic Laboratories prides itself on providing rapid turnaround time, affordable testing and superior customer service. To find out more about Cleveland Clinic Laboratories please visit us at www.clevelandcliniclabs.com.

Past / Future Feature Pages:

May 2015: Computer Software and Systems
June 2015: Diagnostic Testing / Reagents
July 2015: Digital / Imaging / Photography
August 2015: Books & Journals
September 2015: Antibodies / Biomarkers
October 2015: Laboratories

November 2015: Consumable Lab Products / Clinical Lab Analyzers
December 2015: Grossing Equipment / Workstations

Contact Sara Halladay-Klakulak, 248/646-0325, PathOutSales@gmail.com to advertise at PathologyOutlines.com, the world's most popular pathology website.