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July 2012: Imaging / digital / photography

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Digital imaging and photography:
Launching the Practice of Pathology into the 21st Century
Jaleh Mansouri, M.D.


The advent of the digital age has revolutionized the practice and scope of pathology. The transition from film to digital photography has paved the way for the growing field of telepathology. In addition, digital technology has given rise to many novel techniques for data acquisition and analysis such as multispectral imaging. Multispectral imaging utilizes image data obtained at various wavelengths along the electromagnetic spectrum to quantitate the expression of multiple proteins at the cellular and molecular level. Researchers in pathology can apply this modality to construct molecular profiles of diseased tissue or tumors contained in tissue microarrays.

Digital pathology systems have become an essential part of many pathology laboratories in both academic centers and in the private sector. Components of a digital pathology system usually include a digital slide scanner, image analysis computer and software, and camera, and are available from various vendors (e.g. Aperio, Omnyx, Leica). The capabilities of virtual microscopy (e.g. whole slide imaging) are exerting a profound impact in the areas of diagnostics, telecommunication, research, information archiving and retrieval, and education/training. Innovations in digital technology (e.g. 3D pathology real-time quantitative visualization) will continue to transform the practice of pathology well into the 21st century.


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Celestron. Since manufacturing its first telescope in 1960, Celestron has grown to become one of the world's leading telescope makers and enjoys brand-name recognition among serious amateur astronomers for superior optics, outstanding design, and innovative technology. In keeping with this reputation, Celestron microscopes combine the highest quality precision optics with mechanical designs that are state-of-the-art. Celestron professional microscopes are designed for microbiology, pathology, entomology, dermatology, dental usage, veterinary use, and everyday analysis of specimens through advanced research. All Celestron microscopes use high quality glass optics and the bodies are made of metal. Please visit www.celestron.com for more information.

Leica Microsystems is a leading global developer and manufacturer of a broad range of innovative, high-tech, precision optical systems for the imaging, measurement, and analysis of microstructures. Leica Microsystems is one of the market leaders in each of its four divisions: Life Science, Industry, Biosystems, and Surgical. Business areas include Microscopy and Imaging Systems, Specimen Preparation, Medical Equipment, and Antibodies and Reagents. The company offers instruments and system solutions for the entire histopathology process including the NovocastraTM range of antibodies and reagents, consumable products, and clinical microscopes. The company is represented in over 100 countries with 9 manufacturing facilities in 7 countries, sales and service organizations in 20 countries and an international network of dealers.

Milestone Medical provides a portfolio of standardization and documentation products for the grossing workstation. From our MacroPATH D digital imaging, annotation and storage system to the CheckLITE non-contact specimen thickness measurement device and CutMATE grossing forceps, Milestone is building tools to ensure standardization of tissue thicknesses with great processing and results in mind! For more information call 866-995-5300, email info@milestonemed.com or visit us at http://www.milestonemed.com.

Optronics provides Microcast® HD real-time High Definition Co-Observation, which replaces multi-head microscopes. The Optronics Microcast HD offers full 1080p HD digital co-observation from a microscope with 2MP progressive scan digital images at 60 FPS.  The camera system uses 3CCD medical grade RGB imaging technology for precise real-time color reproduction of microscope images without interpolation.  The camera’s ultra high speed automatic camera shutter instantaneously compensates for higher magnification objectives and decreases in illumination.  Optional full 1080p HD image capture of HD microscope images without a computer is available for reports and publications.  Microcast HD eliminates the need for a multi-head microscope. For more information, please visit http://www.optronics.com.

Photodyne Technologies manufactures top of the line computerized macro photography systems for grossing, pathology, histology and other scientific applications, using high resolution digital cameras. Various models are available, and the company specializes in custom designs, usually at no extra charge. These state of the art macroscopic (gross) imaging units revolutionize the picture taking process in the laboratory. The systems enable even non-photographers to take professional quality photos in seconds.  The patented, state-of-the-art systems are used by hundreds of leading hospitals, universities, medical examiner offices and research institutes worldwide.  The included proprietary software allows one to take pictures directly from the computer.  All attributes of the camera are controllable from the computer as well, and the image is viewable in real time on the screen, allowing adjustments before the picture is taken.  The picture is then transferred directly to the computer and is stored on the computer’s hard drive for editing, archiving, or email as an attachment like any other image file via the internet.  Visit us online at www.photodyne.com or contact us at 800-660-2147 or info@photodyne.com.


Past / future feature pages:

March 2012: Tissue processors / other histology
April 2012: Laboratory Accreditation / Education / CME
May 2012: Computer software and systems
June 2012: Diagnostic testing / reagents

August 2012: Books & Journals
September 2012: Antibodies
October 2012: Laboratories
November 2012: Consumable Lab Products / Clinical Lab Analyzers
December 2012: Grossing workstations / lab furniture
January 2013: Billing / consulting / management
February 2013: Microscopes / slide imaging
March 2013: Tissue processors / other histology
April 2013: Laboratory Accreditation / Education / CME
May 2013: Computer software and systems
June 2013: Diagnostic testing / reagents
July 2013: Imaging / digital / photography

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