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Digital Pathology in Microscopy: Looking Beyond the Slide
Jaleh Mansouri, M.D.
Digital pathology, including its role in virtual microscopy, has become a routine part of diagnostic pathology practice as well as education. Digital technology has not only paved the way for whole slide imaging and telepathology, but has also facilitated the development of a number of specialized techniques for microscopic analysis that potentially can increase the accuracy of pathologic diagnosis.
Two of these techniques are hot spot analysis and Raman spectroscopy. In hot spot analysis, computer-generated images of slides showing clusters or "hot spots" containing particular features (e.g., centroid nuclei in Ki-67 analysis; vascularity) allow the pathologist to more accurately and efficiently assess the tissue for specific immunohistochemical features. Raman spectroscopy is a technical modality that allows for the detecting of molecular features in tissue without the use of immunohistochemical stains. In this technique, a laser is employed to gather highly specific spectral images of tissue that reflect particular molecular features. While some of these modalities are still being investigated and validated for their application in routine clinical practice, these examples illustrate the expanding role of digital pathology in the examination of tissue, that far exceeds the visual inspection of hematoxylin and eosin stained slides.
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Leica Biosystems is a global leader in workflow solutions and automation, striving to advance cancer diagnostics to improve patientsí lives. Leica Biosystems provides anatomical pathology laboratories and researchers a comprehensive product range for each step in the pathology process, from sample preparation and staining to imaging and reporting. Our easy-to-use and consistently reliable offerings help improve workflow efficiency and diagnostic confidence. The company is represented in over 100 countries. It has manufacturing facilities in 7 countries, sales and service organizations in 19 countries, and an international network of dealers. The company is headquartered in Nussloch, Germany. Visit www.LeicaBiosystems.com for more information.
Milestone Medical provides a portfolio of standardization and documentation products for the grossing workstation. From our MacroPATH D digital imaging, annotation and storage system to the CheckLITE non-contact specimen thickness measurement device and CutMATE grossing forceps, Milestone is building tools to ensure standardization of tissue thicknesses with great processing and results in mind! For more information call 866-995-5300, email [email protected] or visit us at http://www.milestonemed.com.
OPTRONICS® Microcast® HD clinical microscope cameras deliver instantaneous, real-time HD co-observation performance reducing the need for multi-headed microscopes in conference room settings and enhancing the overall viewing experience in clinical environments such as tumor review boards, pathology labs and teaching applications. The Microcast HD 1080p digital progressive scan video is created using 3CCD medical grade RGB imaging technology for precise real-time color reproduction of microscope images without interpolation. The camera's ultra-high speed automatic camera shutter instantaneously compensates for higher magnification objectives and decreases in illumination. Optional full 1080p HD image capture of HD microscope images without a computer is available for reports and publications. Microcast HD systems are compatible with all popular teleconferencing solutions. For more information, please visit http://www.optronics.com.
Photodyne Technologies manufactures top of the line computerized macro photography systems for grossing, pathology, histology and other scientific applications, using high resolution digital cameras. Various models are available, and the company specializes in custom designs, usually at no extra charge. These state of the art macroscopic (gross) imaging units revolutionize the picture taking process in the laboratory. The systems enable even non-photographers to take professional quality photos in seconds. The patented, state-of-the-art systems are used b hundreds of leading hospitals, universities, medical examiner offices and research institutes worldwide. The included proprietary software allows one to take pictures directly from the computer. All attributes of the camera are controllable from the computer as well, and the image is viewable in real time on the screen, allowing adjustments before the picture is taken. The picture is then transferred directly to the computer and is stored on the computerís hard drive for editing, archiving, or email as an attachment like any other image file via the internet. Visit us online at www.photodyne.com or contact us at 800-660-2147 or [email protected].
Past / Future Feature Pages:
March 2014: Tissue Processors / Other Histology
April 2014: Laboratory Accreditation / Education / CME
May 2014: Computer Software and Systems
June 2014: Diagnostic Testing / Reagents
July 2014: Digital / Imaging / Photography
August 2014: Books & Journals
September 2014: Antibodies / Biomarkers
October 2014: Laboratories
November 2014: Consumable Lab Products / Clinical Lab Analyzers
December 2014: Grossing Equipment / Workstations
January 2015: Billing / Consulting / Management
February 2015: Microscopes / Microscopy Products
March 2015: Tissue Processors / Other Histology
April 2015: Laboratory Accreditation / Education / CME
May 2015: Computer Software and Systems
June 2015: Diagnostic Testing / Reagents
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