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Lymphoma and plasma cell neoplasms Table of contents Lymph nodes:
normal development-general, B cells, T cells, NK cells, normal histology, grossing lymph nodes, features to report
Molecular testing:
theory, FISH, northern blot, PCR, southern blot
Non-Hodgkin’s lymphoma:
general, cytogenetics, staging, staging-pediatric, morphologic clues, hemophagocytic syndrome, chemotherapeutic atypia
B cell disorders:
general, post-rituximab, bone marrow biopsy, classification-historical, WHO classification
B cell lymphoma subtypes:
age-related EBV-associated, ALK positive large cell, Burkitt, unclassifiable-intermediate between Burkitt and diffuse large B cell lymphoma, CLL
Reviewers: Dragos Luca, M.D. (non B cell), Nikhil Sangle, M.D. (B cell/plasma cell neoplasms) (see Reviewers
page)
Last revised: 23 January 2012
Last major update: B cell/plasma cell neoplasms-March 2011, non B cell-January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
diffuse large B cell: diffuse-NOS, CD5+, T cell / histiocyte rich, primary cutaneous-general, primary cutaneous-leg, primary sites-other
follicular: general, childhood, cutaneous, GI
hairy cell leukemia, HCL variant, intravascular large B cell, lymphomatoid granulomatosis, lymphoplasmacytic, mantle cell-classic, mantle cell-blastoid, marginal zone-general, marginal zone-MALT, MALT-primary sites, marginal zone-nodal, mediastinal (thymic), plasmablastic, pre B lymphoblastic leukemia/lymphoma, primary effusion, prolymphocytic leukemia, pyothorax associated, SLL, splenic marginal zone, splenic lymphoma with villous lymphocytes
Plasma cell neoplasms:
general, myeloma, plasmacytoma, heavy chain disease, primary amyloidosis, MGUS, Osteosclerotic myeloma (POEMS), cryoglobulinemia
T/NK cell disorders: general, WHO classification, adult T cell, aggressive NK cell leukemia, anaplastic large cell ALK+, ALK-, angioimmunoblastic T cell, blastic plasmacytoid, chronic lymphoproliferative disorders of NK cells, cutaneous CD4+ small/medium sized T cell lymphoma, cutaneous CD30 positive T cell lymphoproliferative disorders, cutaneous gamma delta T cell lymphoma, enteropathy, epidermotropic CD8+ T cell lymphoma, hepatosplenic, indolent T cell proliferations, mycosis fungoides, NK/T cell lymphoma-nasal type, nodal CD8+ cytotoxic T cell, nonB nonT lymphoblastic, peripheral T cell lymphoma, NOS, primary effusion lymphoma, Sezary syndrome, staging, subcutaneous panniculitis-like, T cell large granular lymphocytic leukemia, T cell lymphoblastic leukemia/lymphoma, T cell prolymphocytic leukemia
Hodgkin lymphoma: general/staging, classic, lymphocyte depleted, lymphocyte rich classical, mixed cellularity, nodular lymphocyte predominant, nodular sclerosis
Post-transplantation: general, WHO classification, plasmacytic hyperplasia/IM-like lesions, polymorphic B cell lymphoproliferative disorders, monomorphic B cell lymphoproliferative disorders, other, graft versus host disease
Other: AIDS associated-general, AIDS associated-examples, EBV+ T cell lymphoproliferative disorders of childhood, other iatrogenic immunodeficiency-associated lymphoproliferative disorders, primary immune disorders related
Alphabetical table of contents
A-E: adult T cell, age-related EBV-associated, aggressive NK cell leukemia, AIDS associated lymphoproliferative disorders-general, AIDS associated lymphoproliferative disorders-specific examples, ALK positive large B cell, anaplastic large cell ALK+, anaplastic large cell ALK-, angioimmunoblastic T cell, B cell lymphoma-general, B cells, blastic plasmacytoid, bone marrow biopsy, Burkitt, chemotherapeutic atypia, chronic lymphoproliferative disorders of NK cells, classification-historical, CLL, cryoglobulinemia, cutaneous CD4+ small/medium sized T cell lymphoma, cutaneous CD30 positive T cell lymphoproliferative disorders, cutaneous gamma delta T cell lymphoma, cytogenetics, diffuse large B cell-CD5+, diffuse large B cell-NOS, diffuse large B cell-primary cutaneous-general, diffuse large B cell-primary cutaneous-leg, diffuse large B cell-primary sites-other, diffuse large B cell-T cell / histiocyte rich, EBV+ T cell lymphoproliferative disorders of childhood, enteropathy, epidermotropic CD8+ T cell lymphoma
F-N: features to report-lymphoma, FISH, follicular-childhood, follicular-cutaneous, follicular-general, follicular-GI, grossing lymph nodes, hairy cell leukemia, hairy cell leukemia variant, heavy chain disease, hemophagocytic syndrome, hepatosplenic, Hodgkin lymphoma-classic, Hodgkin lymphoma-lymphocyte depleted, Hodgkin lymphoma-lymphocyte rich classical, Hodgkin lymphoma-mixed cellularity, Hodgkin lymphoma-nodular lymphocyte predominant, Hodgkin lymphoma-nodular sclerosis, indolent T cell proliferations, intravascular large B cell lymphoma, lymphomatoid granulomatosis, lymphoplasmacytic lymphoma, MALT lymphoma-primary sites, mantle cell lymphoma-blastoid, mantle cell lymphoma-classic, marginal zone lymphoma-general, marginal zone lymphoma-MALT, marginal zone lymphoma-nodal, mediastinal (thymic) lymphoma, MGUS, molecular-theory, morphologic clues, mycosis fungoides, myeloma, NK cells, NK/T cell lymphoma-nasal type, nodal CD8+ cytotoxic T cell, nonB nonT lymphoblastic, non-Hodgkin lymphoma-general, normal lymph node development, normal lymph node histology, northern blot
O-Z: osteosclerotic myeloma (POEMS), other iatrogenic immunodeficiency-associated lymphoproliferative disorders, PCR, peripheral T cell lymphoma, NOS, plasma cell neoplasms, plasmablastic lymphoma, plasmacytoma, post-rituximab, post-transplantation-general, post-transplantation-graft versus host disease, post-transplantation-plasmacytic hyperplasia/IM-like lesions, post-transplantation-monomorphic B cell lymphoproliferative disorders, post-transplantation-other, post-transplantation-polymorphic B cell lymphoproliferative disorders, pre B lymphoblastic leukemia/lymphoma, primary amyloidosis, primary effusion lymphoma-B cell, primary effusion lymphoma-T cell, primary immune disorders related, prolymphocytic leukemia, pyothorax associated lymphoma, Sezary syndrome, SLL, southern blot, splenic lymphoma with villous lymphocytes, splenic marginal zone lymphoma, staging/general-Hodgkin lymphoma, staging-nonHodgkin lymphoma, staging-pediatric, staging-primary cutaneous lymphoma, subcutaneous panniculitis-like, T cells, T cell large granular lymphocytic leukemia, T cell lymphoblastic leukemia/lymphoma, T cell prolymphocytic leukemia, T/NK lymphomas-general, unclassifiable-intermediate between Burkitt and diffuse large B cell lymphoma, WHO classification-B cell/plasma cell, WHO classification-post-transplantation, WHO classification-T/NK lymphomas
Primary references
top
American Journal of Clinical Pathology
American Journal of Surgical Pathology
Archives of Pathology and Laboratory Medicine
Human Pathology
Modern Pathology
Warnke:
Tumors of the Lymph Nodes and Spleen (Atlas of Tumor Pathology, 3rd Series, Vol. 14; 1995)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (IARC 2008)
WHO Classification of Skin Tumours (IARC 2006), PDF
Ioachim's Lymph Node Pathology (2008)
End of Lymphoma and plasma cell neoplasms chapter