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Lymphoma and plasma cell neoplasms

Reviewers: Dragos Luca, M.D. (non B cell), Nikhil Sangle, M.D. (B cell/plasma cell neoplasms) (see Reviewers page)
Last revised: 23 January 2012
Last major update: B cell/plasma cell neoplasms-March 2011, non B cell-January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Table of contents

Lymph nodes: normal development-generalB cellsT cellsNK cellsnormal histologygrossing lymph nodesfeatures to report

Molecular testing: theoryFISHnorthern blotPCRsouthern blot

Non-Hodgkin’s lymphoma: generalcytogeneticsstagingstaging-pediatricmorphologic clueshemophagocytic syndromechemotherapeutic atypia

B cell disorders: generalpost-rituximabbone marrow biopsyclassification-historicalWHO classification

B cell lymphoma subtypes: age-related EBV-associatedALK positive large cellBurkittunclassifiable-intermediate between Burkitt and diffuse large B cell lymphomaCLL
diffuse large B cell:  diffuse-NOSCD5+T cell / histiocyte richprimary cutaneous-generalprimary cutaneous-legprimary sites-other
follicular: generalchildhoodcutaneousGI
hairy cell leukemiaHCL variantintravascular large B celllymphomatoid granulomatosislymphoplasmacyticmantle cell-classicmantle cell-blastoidmarginal zone-generalmarginal zone-MALTMALT-primary sitesmarginal zone-nodalmediastinal (thymic)plasmablasticpre B lymphoblastic leukemia/lymphomaprimary effusionprolymphocytic leukemiapyothorax associatedSLLsplenic marginal zonesplenic lymphoma with villous lymphocytes


Plasma cell neoplasms: generalmyelomaplasmacytomaheavy chain diseaseprimary amyloidosisMGUSOsteosclerotic myeloma (POEMS)cryoglobulinemia

T/NK cell disorders: generalWHO classificationadult T cellaggressive NK cell leukemiaanaplastic large cell ALK+ALK-angioimmunoblastic T cellblastic plasmacytoidchronic lymphoproliferative disorders of NK cellscutaneous CD4+ small/medium sized T cell lymphomacutaneous CD30 positive T cell lymphoproliferative disorderscutaneous gamma delta T cell lymphomaenteropathyepidermotropic CD8+ T cell lymphomahepatosplenicindolent T cell proliferationsmycosis fungoidesNK/T cell lymphoma-nasal typenodal CD8+ cytotoxic T cellnonB nonT lymphoblasticperipheral T cell lymphoma, NOSprimary effusion lymphomaSezary syndromestagingsubcutaneous panniculitis-likeT cell large granular lymphocytic leukemiaT cell lymphoblastic leukemia/lymphomaT cell prolymphocytic leukemia

Hodgkin lymphoma: general/stagingclassiclymphocyte depletedlymphocyte rich classicalmixed cellularitynodular lymphocyte predominantnodular sclerosis

Post-transplantation: generalWHO classificationplasmacytic hyperplasia/IM-like lesionspolymorphic B cell lymphoproliferative disordersmonomorphic B cell lymphoproliferative disordersothergraft versus host disease

Other: AIDS associated-generalAIDS associated-examplesEBV+ T cell lymphoproliferative disorders of childhoodother iatrogenic immunodeficiency-associated lymphoproliferative disordersprimary immune disorders related

Alphabetical table of contents

A-E: adult T cellage-related EBV-associatedaggressive NK cell leukemiaAIDS associated lymphoproliferative disorders-generalAIDS associated lymphoproliferative disorders-specific examplesALK positive large B cellanaplastic large cell ALK+anaplastic large cell ALK-angioimmunoblastic T cellB cell lymphoma-generalB cellsblastic plasmacytoidbone marrow biopsyBurkittchemotherapeutic atypiachronic lymphoproliferative disorders of NK cellsclassification-historicalCLLcryoglobulinemiacutaneous CD4+ small/medium sized T cell lymphomacutaneous CD30 positive T cell lymphoproliferative disorderscutaneous gamma delta T cell lymphomacytogeneticsdiffuse large B cell-CD5+diffuse large B cell-NOSdiffuse large B cell-primary cutaneous-generaldiffuse large B cell-primary cutaneous-legdiffuse large B cell-primary sites-otherdiffuse large B cell-T cell / histiocyte richEBV+ T cell lymphoproliferative disorders of childhoodenteropathyepidermotropic CD8+ T cell lymphoma

F-N: features to report-lymphomaFISHfollicular-childhoodfollicular-cutaneousfollicular-generalfollicular-GIgrossing lymph nodeshairy cell leukemiahairy cell leukemia variantheavy chain diseasehemophagocytic syndromehepatosplenicHodgkin lymphoma-classicHodgkin lymphoma-lymphocyte depletedHodgkin lymphoma-lymphocyte rich classicalHodgkin lymphoma-mixed cellularityHodgkin lymphoma-nodular lymphocyte predominantHodgkin lymphoma-nodular sclerosisindolent T cell proliferationsintravascular large B cell lymphomalymphomatoid granulomatosislymphoplasmacytic lymphomaMALT lymphoma-primary sitesmantle cell lymphoma-blastoidmantle cell lymphoma-classicmarginal zone lymphoma-generalmarginal zone lymphoma-MALTmarginal zone lymphoma-nodalmediastinal (thymic) lymphomaMGUSmolecular-theorymorphologic cluesmycosis fungoidesmyelomaNK cellsNK/T cell lymphoma-nasal typenodal CD8+ cytotoxic T cellnonB nonT lymphoblasticnon-Hodgkin lymphoma-generalnormal lymph node developmentnormal lymph node histologynorthern blot

O-Z: osteosclerotic myeloma (POEMS)other iatrogenic immunodeficiency-associated lymphoproliferative disordersPCRperipheral T cell lymphoma, NOSplasma cell neoplasmsplasmablastic lymphomaplasmacytomapost-rituximabpost-transplantation-generalpost-transplantation-graft versus host diseasepost-transplantation-plasmacytic hyperplasia/IM-like lesionspost-transplantation-monomorphic B cell lymphoproliferative disorderspost-transplantation-otherpost-transplantation-polymorphic B cell lymphoproliferative disorderspre B lymphoblastic leukemia/lymphomaprimary amyloidosisprimary effusion lymphoma-B cellprimary effusion lymphoma-T cellprimary immune disorders relatedprolymphocytic leukemiapyothorax associated lymphomaSezary syndromeSLLsouthern blotsplenic lymphoma with villous lymphocytessplenic marginal zone lymphomastaging/general-Hodgkin lymphomastaging-nonHodgkin lymphomastaging-pediatricstaging-primary cutaneous lymphomasubcutaneous panniculitis-likeT cellsT cell large granular lymphocytic leukemiaT cell lymphoblastic leukemia/lymphomaT cell prolymphocytic leukemiaT/NK lymphomas-generalunclassifiable-intermediate between Burkitt and diffuse large B cell lymphomaWHO classification-B cell/plasma cellWHO classification-post-transplantationWHO classification-T/NK lymphomas

Primary references
top
American Journal of Clinical Pathology
American Journal of Surgical Pathology
Archives of Pathology and Laboratory Medicine
Human Pathology
Modern Pathology
Warnke: Tumors of the Lymph Nodes and Spleen (Atlas of Tumor Pathology, 3rd Series, Vol. 14; 1995)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (IARC 2008)
WHO Classification of Skin Tumours (IARC 2006), PDF
Ioachim's Lymph Node Pathology (2008)

End of Lymphoma and plasma cell neoplasms chapter