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30 July 2015: Bio SB is pleased to announce a new line of rabbit monoclonal antibodies for IHC with extensive protein immunogenicity analysis of targeted epitopes, high sensitivity specificity and low background noise.

Introducing N-RAS (Q61R) - RMab:

NRAS is an enzyme that in humans is encoded by the NRAS gene. The NRAS oncogene is a member of the Ras gene family. It is mapped on chromosome 1. The Ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-Ras to transform cultured cells and are implicated in a variety of human tumors.

Tumor mutation profiling has identified the highest incidence of NRAS mutations in melanoma (~30%), acute myeloid leukemia (~15%) and thyroid carcinoma (5-10%). The Q61R is the most common NRAS mutation found in melanoma that is thought to occur due to UV and radiation exposure. It is a commonly acquired mutation found in primary melanomas from melanoma-prone families that have known germline CDKN2A mutations, and it is associated with loss of the wild-type NRAS allele. It is also detected in patients with congenital melanocytic nevi (CMN), which can develop into malignant melanoma. The NRAS Q61R is the most common oncogenic event in encapsulated thyroid tumors of follicular cell origin with high-grade features. 20% of adrenocortical tumors solely carry this RAS alteration; however, adrenocortical hyperplasia does not, suggesting NRAS Q61R is an oncogenic event driving adrenocortical tumor development.

For more information call 805-692-2768, email info@biosb.com or visit http://www.biosb.com.





24 July 2015: Quidel Corporation, a provider of rapid diagnostic testing solutions, cellular-based virology assays and molecular diagnostic systems, announced that it has received 510(k) clearance from the United States Food and Drug Administration (FDA) to market Quidel's new instrumented molecular system -- Solana -- and for the Solana Group A Strep Assay (Solana GAS Assay) for the rapid, qualitative detection of β-hemolytic, Group A Streptococcus (Streptococcus pyogenes) nucleic acids isolated from throat swab specimens from patients with signs and symptoms of pharyngitis, such as sore throat.

The Solana molecular platform leverages the Helicase-Dependent Amplification (HDA) technology that is resident in Quidel's AmpliVue® molecular product line to generate a fast and accurate test result. Solana can process up to 12 patient samples in each 30-minute run, thereby providing time-saving workflow advantages to healthcare professionals in moderately complex settings.

The Solana Group A Strep Assay is an easy-to-use, rapid molecular diagnostic test that has superb clinical accuracy and does not require culture confirmation of negative results. The assay requires no upfront extraction of DNA and generates an accurate result in approximately 30 minutes.

Click here for more information.




22 July 2015:

The World's First and Only
ARUP's Sort-to-Light System Illuminates Efficiencies


Aside from the "Wow" factor in seeing a "rainbow" light up in a medical lab, ARUP's Laboratories newest generation of the Sort-to-Light system (S2L) further ensures efficiency and reliability as some 200,000 manually delivered specimens enter and exit through its colorful doors each month. This accounts for 15-18 percent of ARUP's monthly volume of non-track specimens.

It is the world's first and only medical laboratory S2L system, built to decrease compromised and lost specimens. It allows for double the capacity with an increase in number of operators and total sort groups.

For more information, please click here.




8 July 2015: Kubtec® releases the new 17" x 14" wireless flat panel detector for medical imaging. Lightweight, durable and easy to use, the DIGIVIEW 395 incorporates Kubtec's matchless imaging capabilities and rapid image acquisition and display with wireless freedom. Designed for versatility and portability, the DIGIVIEW 395 can be used anywhere medical imaging is required. The DIGIVIEW 395 features wireless data transmission, giving medical personnel immediate access to critical information for faster interpretation and diagnosis.

Kubtec's high quality medical imaging technology and unparalleled reliability, coupled with the company's release of the DIGIVIEW 395 advanced wireless detector technology, allows radiology departments to meet the demands for rapid deployment of imaging services with more compassionate patient care anywhere in the hospital.

For more information, please visit http://kubtec.com.




1 July 2015: Oxford Gene Technology, Inc. is proud to announce the extension of the Cytocell Pathology FISH probe range with eight new probes available this month.

Probe nameProbe regionCat. no.
1p361p36.32LPS513-A
1q251q25.2LPS512-A
19q1319q13.33LPS516-A
19p1319p13.2LPS515-A
RET Proximal10q11.21LPS508-A
RET Distal10q11.21LPS509-A
ROS1-GOPC(FIG) Proximal6q22.1LPS510-A
ROS1-GOPC(FIG) Distal6q22.1LPS511-A

Discover the new additions to our pathology portfolio and benefit from: For more information on these, and our extensive range of pathology and hematology probes, visit our website or contact contact@ogt.com.




29 June 2015: Bio SB is pleased to announce a new line of rabbit monoclonal antibodies for IHC with extensive protein immunogenicity analysis of targeted epitopes, high sensitivity specificity and low background noise.

Introducing SOX-10 - RMab:

Transcription factor SOX-10 is a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins.

This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

SOX-10 is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. In scar specimens, immature fibroblasts, epithelioid granulomas and histiocytic proliferations can histopathologically mimic residual melanoma, and even be positive for MiTF and S100.

For more information call 805-692-2768, email info@biosb.com or visit http://www.biosb.com.





15 June 2015: Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, announces approval of the VENTANA ALK (D5F3) CDx Assay by the US Food and Drug Administration (FDA) as a companion diagnostic to aid in the identification of patients for Pfizer's FDA approved targeted therapy, XALKORI® (crizotinib). The VENTANA ALK Assay was approved as a CE-IVD in Europe in 2012 and was approved by the Chinese Food and Drug Administration (CFDA) in 2013. With this US FDA Class III approval, ALK IHC testing is now widely accessible on VENTANA BenchMark1 immunohistochemistry (IHC) instruments globally, can be easily integrated into standard lab workflow and offers fast test results with a binary, straightforward scoring method.


Positive case of lung tissue stained for ALK with VENTANA ALK (D5F3)
CDx Assay


Negative case of lung tissue stained for ALK with VENTANA ALK (D5F3)
CDx Assay

For more information visit www.ventana.com.




29 May 2015: Bio SB is pleased to announce a new line of rabbit monoclonal antibodies for IHC with extensive protein immunogenicity analysis of targeted epitopes, high sensitivity specificity and low background noise.

Introducing PD-L1:

Programmed death-ligand 1 (PD-L1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other diseases.

The upregulation of PD-L1 may allow cancers to evade the host immune system. Ovarian cancer patients with higher expression of PD-L1 had a significantly poorer prognosis than those with lower expression. PD-L1 expression correlates inversely with intraepithelial CD8+ T-lymphocyte count, suggesting that PD-L1 on tumor cells may suppress antitumor CD8+ T cells. The PD-1/PD-L1 interaction is implicated in autoimmunity from several lines of evidence.

For more information call 805-692-2768, email info@biosb.com or visit http://www.biosb.com.




13 May 2015: Mopec proudly announces AC Peroxy.

For more information call +1 (800) 362-8491, email info@mopec.com or visit www.Mopec.com.




17 April 2015: Presenting PrestoCHILL, the Science of cryoembedding for high-quality frozen sections. Standardize and accelerate the production of optimally prepared specimen embedded cryostat chucks without freezing artifacts in 60 seconds. The patented PrestoCHILL is an all-dry system, with no use of liquid nitrogen, CO2, or Isopentane.


Learn more about the PrestoCHILL by calling 866-995-5300, emailing info@milestonemed.com, or visiting www.milestonemed.com.





17 April 2015: Rankin Biomedical proudly announces its ColorPro Stainer. The ColorPro Stainer offers consistent staining of slides in an easy to use compact, cost conscious package. It is ideal for Mohs techniques, Special Stains, and general surgical pathology frozen sections.

For more information, please click here.





25 March 2015: Evolve Your Lab With SmartStation Technology. Mopec introduces The Touch Screen Grossing Station, designed to improve worker safety, increase operational versatility and provide more reliable equipment for your laboratory.

Mopec's newest workstation focuses on ergonomics, workflow and convenience. The control panel application monitors all functions for the station, includes touch-free operation and supports a new formalin management system. Our SmartStation Technology gives the Touch Screen Grossing Station exactly what your lab needs for the best dissection experience.


For more information call 1-800-362-8491, email info@mopec.com or click here.



End of New Products and Services page



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