Breast malignant, males, children
Carcinoma subtypes
Carcinoma subtypes - general


Topic Completed: 1 February 2012

Minor changes: 4 July 2020

Revised: 24 January 2019

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PubMed search: breast carcinoma [title] subtypes WITH malignan

Monika Roychowdhury, M.D.
Page views in 2020 to date: 8
Cite this page: Roychowdhury M OLD Other subtypes-general. PathologyOutlines.com website. http://www.pathologyoutlines.com/oldtopics/breastmalignantcarcinomasubtypesgeneral.html. Accessed August 7th, 2020.
Definition / general
Positive stains
Molecular / cytogenetics description
  • DNA microarray profiling studies have divided invasive breast carcinoma into molecular subtypes: luminal A (ER+, HER2–), luminal B (ER+, HER2+), HER2 positive (ER–, HER2+), normal breast-like (ER+, PR+, HER2–) and basal-like (ER–, HER2–, EGFR+ or cytokeratin 5 / 6+)
  • Most histologic subtypes other than lobular and apocrine belong to only one molecular subtype (J Pathol 2008;216:141)
  • By hierarchical clustering analysis, some histological subtypes types appear to be discrete entities (micropapillary carcinoma), but others appear similar to each other (tubular and lobular)
Additional references
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