Breast malignant
In situ carcinoma
Neuroendocrine DCIS

Topic Completed: 1 January 2012

Minor changes: 25 June 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Neuroendocrine DCIS

Dina Kandil, M.D.
Page views in 2020 to date: 6
Cite this page: Kandil D. OLD Neuroendocrine. website. Accessed August 7th, 2020.
Definition / general
  • DCIS in which 50% or more cells express neuroendocrine markers (Histopathology 2008;53:288)
  • Regarded by some as DCIS with neuroendocrine features rather than a distinct type
Clinical features
Case reports
Microscopic (histologic) description
  • Solid lobular growth, neuroendocrine-like festoons and rosettes and prominent fibrovascular septa
  • Cells are polygonal, oval or spindled with abundant granular eosinophilic cytoplasm and bland ovoid nuclei
  • Accumulation of basophilic intracellular mucin
  • Often pagetoid spread and well developed vascular network
  • Variable stromal sclerosis or signet ring cells
  • Usually no necrosis
Microscopic (histologic) images

AFIP images

Focal Grimelius+ cells

Small cells with
dense, deeply stained
amphophilic cytoplasm
and uniform round nuclei

Case of the Week #45


Cytology description
Cytology images

Images hosted on other servers:

Various images

Negative stains
Electron microscopy description
  • Dense core neurosecretory granules, larger mucigen granules
Differential diagnosis
  • Florid epithelial hyperplasia and papilloma: lacks the monomorphic cell population associated with DCIS, negative for neuroendocrine markers
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