Breast malignant
Breast cancer
Pregnancy related carcinoma


Topic Completed: 1 February 2012

Minor changes: 21 June 2020

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Pregnancy related carcinoma

Monika Roychowdhury, M.D.
Page views in 2020 to date: 4
Cite this page: Roychowdhury M. OLD Pregnancy. PathologyOutlines.com website. http://www.pathologyoutlines.com/oldtopics/breastmalignantpregnancy.html. Accessed August 7th, 2020.
Clinical features
  • Estimated incidence of 1 case per 3,000 pregnancies
  • Increasing incidence due to delay of childbearing (Obstet Gynecol 2009;114:568)
  • Associated with higher stage and larger primary tumors than non pregnancy associated tumors (Obstet Gynecol 2008;112:71)
  • Similar features as breast carcinoma in other young women, and clinical course may not be as aggressive as initially reported (Cancer 2003;98:1055)
  • Mammogram is less sensitive during pregnancy due to increased parenchymal density; ultrasound is best technique for evaluation of breast masses during pregnancy or lactation
  • Diagnosis may be delayed (Cancer 2009;115:1174)
  • Tumors usually contain rare fetal cells (Breast Cancer Res 2008;10:R14)
Treatment
Microscopic (histologic) description
  • 80% high grade
  • Cancerization of lobules in 79%
Microscopic (histologic) images

Images hosted on other servers:

Extensive cancerization of lobules

Lactation associated colloid carcinoma is MUC2+

Figures 1 and 2

Positive stains
Negative stains
Molecular / cytogenetics images

Images hosted on other servers:

FISH shows cells from
male fetuses within tumor

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