Table of ContentsDefinition / general | Microscopic (histologic) description | Positive stains | Differential diagnosis
Cite this page: Kandil D OLD Signet ring cell. PathologyOutlines.com website. http://www.pathologyoutlines.com/oldtopics/breastmalignantsignetringcellDCIS.html. Accessed August 7th, 2020.
Definition / general
Microscopic (histologic) description
- Cells have eccentric nuclei that are indented at the nuclear border by a cytoplasmic vacuole with a central minute secretion droplet
- Clear cells of normal nipple-areola complex: varied morphology but no atypia; usually morphology consistent with pagetoid dyskeratosis, HMW CK+ (Histol Histopathol 2009;24:367)
- Histiocytes: may appear in lymph nodes too; mucin negative, CD68+ (Am J Clin Pathol 1989;92:509)
- Non-specific cytoplasmic halos: usually a fixation artifact, mucin negative