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Bulging vocal cord mass
Contributed by Vancouver General Hospital
Characteristic histologic features
Involvement of the trachea
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Apolipoprotein AI and transthyretin amyloidosis
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Homogenous proteinous material with calcification under bronchus epithelium is Congo red+
Massive amyloid deposits
69 year old woman with seropositive erosive RA
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Sagittal section
Coronal section
Entrance viewed from above
Laryngoscopic view
Laryngeal cartilages
Vocal cords and muscles
Muscles
Ligaments
Trachea and bronchi
Tracheal bifurcation
Transverse section
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True and false vocal cords
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True and false vocal cords
Transverse section of trachea
Contributed by Steven Catinchi-Jaime, M.D.
Malignant fibrous histiocytoma and squamous cell carcinoma arising in a vocal chord
Contributed by Steven Catinchi-Jaime, M.D.
Malignant fibrous histiocytoma and squamous cell carcinoma arising in a vocal chord
Malignant fibrous histiocytoma and squamous cell carcinoma arising in a vocal chord
Alpha-1-antichymotrypsin
Vimentin
CD68
Cytokeratin AE1 / AE3
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Basaloid squamous cell carcinoma
Various images
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6 year old child's trachea
and major bronchi with mucosa
damaged by toxin produced by
Corynebacterium diphtheriae
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Coronal cross section of larynx showing saccule
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MRI
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Spherical bulges covered by smooth epithelium
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Cyst in glottic region
Contributed by Arpita Jindal, M.D.
Pseudostratified columnar epithelium lined cyst
Cyst lining showing squamous metaplasia
Intraluminal infolding with focal lymphoid collection
Columnar mucinous lining, basally located nuclei
Pseudostratified columnar epithelium with cilia
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Acute laryngoepiglottitis: H. influenza (site unknown)
Table 1: WHO 2022 epithelial neuroendocrine neoplasms of the upper aerodigestive tract and salivary glands (Head Neck Pathol 2022;16:123)
| Neuroendocrine neoplasm | Tumor category | Diagnostic criteria |
| Well differentiated neuroendocrine neoplasm (neuroendocrine tumor, NET) | Well differentiated neuroendocrine tumor, grade 1 (NET, G1) | No necrosis and < 2 mitoses/2 mm²
Ki67 < 20% |
| Well differentiated neuroendocrine tumor, grade 2 (NET, G2) | Necrosis or 2 - 10 mitoses/2 mm²
Ki67 < 20% | |
| Well differentiated neuroendocrine tumor, grade 3 (NET, G3) | > 10 mitoses/2 mm²
Ki67 > 20% Absence of NEC cytomorphology | |
| Poorly differentiated neuroendocrine neoplasm (neuroendocrine carcinoma, NEC) | Small cell neuroendocrine carcinoma | > 10 mitoses/2 mm²
Ki67 > 20% (often > 70%) Small cell NEC cytomorphology |
| Large cell neuroendocrine carcinoma | > 10 mitoses/2 mm²
Ki67 > 20% (often > 50%) Large cell NEC cytomorphology |
Contributed by Nazim Benzerdjeb, M.D., Ph.D.
Well differentiated
Large cell
Small cell
Mixed pattern
Low Ki67
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CT of tracheal papilloma
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Laryngectomy for massive papillomas
Contributed by Kavita Umrau, M.B.B.S. and Bin Xu, M.D., Ph.D.
Branching finger-like papillae
Basal and parabasal mitosis
Basal and parabasal hyperplasia
Koilocytic changes
Malignant transformation
Low risk HPV
Contributed by Michael Elliott, M.B.B.S., M.Phil. and Carsten Palme, M.B.B.S.
Ulcerated hypopharyngeal lesion
Keratotic hypopharyngeal lesion
Polypoid ulcerated hypopharyngeal lesion
Contributed by Kelly Magliocca, D.D.S., M.P.H.
Laryngopharyngectomy, opened posteriorly (pT4a)
Laryngopharyngectomy,
sectioned (pT4a)
Contributed by Kyriakos Chatzopoulos, M.D., Ph.D.
Vocal cord nodule
Contributed by Kyriakos Chatzopoulos, M.D., Ph.D.
Hyperplastic squamous mucosa
Fibroblastic myxoid stroma
Stromal hyalinization
Franchi: 2020
Gnepp: 2021
Stelow: 2020
Thompson: 2022
Wenig: 2017
Wenig: 2024
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