Explanted liver with large areas of hemorrhage and necrosis
Microscopic (histologic) images
Contributed by Anthony W.H. Chan, M.B.Ch.B.
Panacinar hemorrhagic necrosis
Prominent ductular reaction
Collapse of reticulin framework
Images hosted on other servers:
Post isoflurane anesthesia
Explanted liver demonstrating massive necrosis and architectural collapse
Hepatic failure
Diagrams / tables
N/A
Radiology images
N/A
Clinical images
N/A
Gross images
Contributed by Anthony W.H. Chan, M.B.Ch.B.
Acute hepatic failure
HTML NOTE: Keep this image?
Images hosted on other servers:
Explanted liver with large areas of hemorrhage and necrosis
Microscopic (histologic) images
Contributed by Anthony W.H. Chan, M.B.Ch.B.
Panacinar hemorrhagic necrosis
Prominent ductular reaction
Extensive zone 3 hemorrhagic necrosis
Absence of significant fibrosis
Collapse of reticulin framework
Cytology images
N/A
Electron microscopy images
N/A
Molecular / cytogenetics images
N/A
Videos
N/A
Hepatic infantile hemangioma
Diagrams / tables
Images hosted on other servers:
Clinical presentation
Pathophysiology
Radiology images
Images hosted on other servers:
Multifocal and diffuse HIH
Clinical images
Not available
Gross images
Contributed by Xuchen Zhang, M.D., Ph.D.
Focal hemorrhagic and fibrotic changes
Microscopic (histologic) images
Contributed by Xuchen Zhang, M.D., Ph.D. and Deepali Jain, M.D.
Vascular channels
Periphery of the tumor
Center of the tumor
Unencapsulated vascular tumor
Junction between liver and tumor
Small and capillary vascular channels
CD34 IHC stain
CD34 IHC stain
Cytology images
Images hosted on other servers:
Tumoral endothelial cells
Electron microscopy images
Not applicable
Molecular / cytogenetics images
Not applicable
Videos
Not available
Hepatic small vessel neoplasm
Radiology images
Contributed by Carlo M. Cicala, M.D.
Abdominal CT
Abdominal MRI
Gross images
Contributed by Ryan M. Gill, M.D.
Tan-brown, unencapsulated, mottled tumor
Microscopic (histologic) images
Contributed by Ryan M. Gill, M.D.
Infiltrating small vessels
Extramedullary hematopoiesis (megakaryocyte)
Densely packed infiltrative vessels
Reticulin stain
CD31 IHC stain
ERG IHC stain
CD34 IHC stain
Ki67
Ki67 in hepatic angiosarcoma
Hepatitis (acute and chronic)-general
Radiology images
Images hosted on other servers:
Acute viral hepatitis with gallbladder wall thickening
Hepatic cirrhosis with portal hypertension
Gross images
Images hosted on other servers:
Viral hepatitis with necrosis and lobular collapse
Macronodular cirrhosis of liver
Micronodular cirrhosis of liver with fatty change
Microscopic (histologic) images
Contributed by Rifat Mannan, M.B.B.S., M.D., Alexander Boyd, M.B.Ch.B., Owen Cain, M.B.Ch.B., Abhishek Chauhan, Ph.D. and Gwilym J. Webb, M.B.Ch.B., M.A.
Lymphoid aggregate: hepatitis C
Acute hepatitis histopathology
Chronic hepatitis B
Interface hepatitis
Nonalcoholic fatty liver disease
Alpha-1 antitrypsin deficiency
Videos
Histopathology of liver in viral hepatitis
Histopathology of liver in chronic hepatitis
Hepatitis A virus (HAV)
Diagrams / tables
Images hosted on other servers:
Drawing of virion
Microscopic (histologic) images
Images hosted on other servers:
Portal and periportal inflammation with some ballooning degeneration
Lobular inflammation
Confluent necrosis (PAS)
Acidophil bodies and hydropic degeneration
With marked cholestasis
Hepatitis B virus (HBV)
Diagrams / tables
Images hosted on other servers:
Worldwide all age prevalence for HBsAg in 2019
Interpretation of HBV immunologic markers
Radiology images
Not relevant
Clinical images
Not relevant
Gross images
Not relevant
Microscopic (histologic) images
Contributed by Monika Vyas, M.D.
Liver parenchymal collapse
Reticulin stain
Trichrome stain
Hepatocyte dropout
Acidophil (councilman) body
Liver cirrhosis
Ground glass HBsAg inclusion
HBsAg IHC stain
Hepatocellular carcinoma
Cytology images
Not relevant
Electron microscopy images
Not relevant
Molecular / cytogenetics images
Not relevant
Videos
Not relevant
Hepatitis B virus (HBV)
Diagrams / tables
Images hosted on other servers:
Drawing of virion
Gross images
Images hosted on other servers:
Atrophic liver due to fulminant hepatitis
Microscopic (histologic) images
Images hosted on other servers:
Lobular disarray
Acidophil bodies
Submassive necrosis
Ground glass hepatocytes in asymptomatic carrier
Moderate portal inflammation
Portal inflammation with minimal interface hepatitis
Portal fibrosis with minimal inflammation (trichrome)
Severe with marked portal inflammation and piecemeal necrosis
Immunostain for surface antigen
Immunostain for core antigen (in nuclei)
Hepatitis C virus (HCV)
Microscopic (histologic) images
Images hosted on other servers:
Portal lymphocytosis
Bile duct involvement
Portal - portal fibrosis
Immunostain
Hepatoblastoma
Radiology images
Contributed by Rui Caetano Oliveira, M.D. and Maria Augusta Cipriano, M.D.
Hepatic ultrasonography
Hepatic CT
Gross images
Contributed by Rui Caetano Oliveira, M.D. and Maria Augusta Cipriano, M.D.
Gross examination
Microscopic (histologic) images
Contributed by Rui Caetano Oliveira, M.D. and Maria Augusta Cipriano, M.D.
Hepatoblastoma patterns
Small cell undifferentiated pattern
Fetal component
Small nests
Therapy changes
Keratin staining
Polyclonal CEA
CK19 staining
Beta catenin staining
Hepatocellular adenoma
Diagrams / tables
Contributed by Avani Pendse, M.D., Ph.D.
Subtypes
Radiology images
Images hosted on other servers:
HA-H MRI
HA-B MRI
Gross images
Contributed by Avani Pendse, M.D., Ph.D.
HA-I
Images hosted on other servers:
HA-H, HA-I, HA-B
Malignant transformation
Microscopic (histologic) images
Contributed by Monica Abdelmalak, M.D., Avani Pendse, M.D., Ph.D. and Raul S. Gonzalez, M.D.
HA-H: well defined border
HA-H: marked steatosis
HA-H: reticulin
HA-H: HSP70
HA-H: CD34
HA-H: glypican 3
HA-H: beta catenin
HA-H: glutamine synthetase
HA-H: SAA
HA-I: sinusoidal dilatation
HA-I: inflammation
HA-I: SAA
HA-I: beta catenin
HA-I: glutamine synthetase
HA-I: glypican 3
HA-B: focal pseudoacinar architecture
Hepatocellular carcinoma overview
Diagrams / tables
Images hosted on other servers:
Diagnostic algorithm of liver nodule workup in cirrhotic patients
Barcelona Clinic Liver Cancer algorithm for patient management
Contributed by Michelle Wilkinson, B.S., P.A. (ASCP)
Red-brown cut surface
Microscopic (histologic) images
Contributed by Kimberley J. Evason, M.D., Ph.D.
Lobule
Trichrome
Portal tract
PASD
Trichrome large portal tract
Hepatocytes and sinusoids
Central vein
Canaliculi
Reticulin
Kupffer cells
Iron
Cytology images
Contributed by Kimberley J. Evason, M.D., Ph.D.
Benign hepatocytes, Diff-Quik
Benign hepatocytes, Pap
Electron microscopy images
Images hosted on other servers:
Endothelium, tangential cut
Bile canaliculus
Infantile hemangioendothelioma / hemangioma
Microscopic (histologic) images
Case #432
4x
10x
20x
20x
40x
CD34 2x
CD34 20x
Intraductal papillary neoplasm of the bile ducts
Radiology images
Images hosted on other servers:
Dilated duct
Papillary projections
Gross images
Images hosted on other servers:
Friable, villiform projections
Microscopic (histologic) images
Contributed by Zachary Dong, M.D.
Friable papillary projections
Papillary lesion
Pancreaticobiliary type epithelium
Intrahepatic biliary atresia
Microscopic (histologic) images
Images hosted on other servers:
Liver biopsy
Intrahepatic cholangiocarcinoma (small and large duct types)
Diagrams / tables
Images hosted on other servers:
Classifications of cholangiocarcinoma
Radiology images
Images hosted on other servers:
CT scan
Ultrasound
MRI
Gross images
Images hosted on other servers:
Mass forming cholangiocarcinoma
Microscopic (histologic) images
Contributed by Wei Chen, M.D., Ph.D., Omid Savari, M.D. and @RaulSGonzalezMD on Twitter
Large duct type iCCA
Small duct type iCCA
Anastomosing glands
Ductal plate malformation pattern
With necrosis
With sclerotic stroma
Irregular nuclear features
Infiltrating hepatic parenchyma
Poorly differentiated
Intrahepatic cholangiocarcinoma
Cytology images
Images hosted on other servers:
Cholangiocarcinoma on FNA
Lafora disease
Microscopic (histologic) images
Case #361
H&E images
PAS+ stain
Images hosted on other servers:
Periportal hepatocytes
PASD
Large duct obstruction
Microscopic (histologic) images
Contributed by Raul S. Gonzalez, M.D.
Acute large duct obstruction
Chronic large duct obstruction
Large regenerative nodule
Microscopic (histologic) images
Contributed by Naziheh Assarzadegan, M.D.
Small cell change
Large cell change
Large cell change with adjacent cirrhotic nodule
Images hosted on other servers:
Large regenerative
nodule in a patient with
Budd-Chiari syndrome
Late T cell mediated (cellular) rejection
Diagrams / tables
Grading descriptors of late onset T cell mediated rejection presenting as isolated central perivenulitis (Hepatology 2006;44:489)
Description
Biopsy findings
Minimal or indeterminate
Perivenular inflammation involving a minority of terminal hepatic veins, with patchy perivenular hepatocyte loss but without confluent perivenular necrosis
Mild
As above but involving most terminal hepatic veins
Moderate
As above, with focal confluent perivenular hepatocyte dropout and mild or moderate inflammation but without bridging necrosis
Severe
As above, with confluent perivenular hepatocyte dropout and inflammation involving most hepatic venules and with central to central bridging necrosis
Contributed by Puja Sakhuja, M.D., Surbhi Goyal, M.D. and Lavleen Singh, M.D.
Bland cholestasis with hepatocytic pseudorosettes
Giant cell
transformation
with pseudoacinar
rosettes
Extensive portal fibrosis with ductular proliferation
Cholestasis with ductular proliferation
Reduced canalicular expression of CD10
Loss of BSEP immunoexpression
Canalicular BSEP expression
Loss of MDR3 immunoexpression
Canalicular MDR3 expression
Electron microscopy images
Contributed by Puja Sakhuja, M.D.
Amorphous, fine filamentous bile
Images hosted on other servers:
Distended bile canaliculi with coarse and granular bile
Q fever
Microscopic (histologic) images
Contributed by Raul S. Gonzalez, M.D.
Liver with Q fever
Fibrin ring granulomas
Q fever granulomas
Videos
A summary of Q fever
Recurrent disease
Diagrams / tables
Contributed by Lidiane Vieira Marins, M.D., Ph.D.
Basic liver injury patterns
Image key
Normal appearance
Acute recurrent HBV / HCV / AIH
Chronic recurrent HBV / HCV
Chronic recurrent AIH
Recurrent PSC
Recurrent PBC
Recurrent ALD / MASLD
Recurrent HCC
Radiology images
Not relevant to this topic
Clinical images
Not relevant to this topic
Gross images
Not relevant to this topic
Microscopic (histologic) images
Contributed by Raul S. Gonzalez, M.D.
Acute R-HCV
Fibrosing cholestatic hepatitis
R-PSC
R-PBC
Cytology images
Not relevant to this topic
Electron microscopy images
Not relevant to this topic
Molecular / cytogenetics images
Not relevant to this topic
Videos
Recurrent disease post-liver transplantation
Recurrent pyogenic cholangitis
Radiology images
Images hosted on other servers:
Cholangiogram with stones
CT with stones
Clinical images
Images hosted on other servers:
Intrahepatic stone
Gross images
Images hosted on other servers:
Duct dilatation and stones
Microscopic (histologic) images
Contributed by Raul S. Gonzalez, M.D.
Hepatolithiasis
Periductal fibrosis
Duct inflammation
Schistosomiasis
Microscopic (histologic) images
Contributed by Dr. Keloth Pradeep
82 year old woman with liver biopsy for presumed liver metastases, based on CT / MRI findings: schistosomial ova and metastatic adenocarcinoma in liver
Images hosted on other servers:
Eggs in intestinal mucosa
Dense periportal fibrosis
Secondary biliary cirrhosis
Microscopic (histologic) images
Contributed by Raul S. Gonzalez, M.D.
Biliary type cirrhosis
Segmental atrophy
Diagrams / tables
Contributed by Naziheh Assarzadegan, M.D.
Segmental atrophy stages
Radiology images
Contributed by Naziheh Assarzadegan, M.D.
Mass, concerning for cholangiocarcinoma
Microscopic (histologic) images
Contributed by Naziheh Assarzadegan, M.D.
Subcapsular lesion
Abnormal thick walled blood vessels
Biliary cyst
Simple biliary cyst
Radiology images
Contributed by Lokman Cevik, M.D.
Large cyst in the liver
Multiple cysts in the liver
Clinical images
Images hosted on other servers:
Ruptured cyst
Perforated lesion of hepatic cyst
Microscopic (histologic) images
Contributed by Lokman Cevik, M.D. and Wei Chen, M.D., Ph.D.