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Lung

Authors: Ali Alzeer, M.D., Atreyee Basu, M.D., Jennifer M. Boland, M.D., Rachel Bowden, M.B.B.S., M.Sc., Luka Brčić, M.D., Ph.D., Andrey Bychkov, M.D., Ph.D., Matthew J. Cecchini, M.D., Ph.D., Kyriakos Chatzopoulos, M.D., Ph.D., Heather I-Hsuan Chen-Yost, M.D., Luca Cima, M.D., Brittany Cody, D.O., Junya Fukuoka, M.D., Ph.D., Andréanne Gagné, M.D., M.Sc., Carolyn Glass, M.D., Ph.D., Hongxing "Simon" Gui, M.D., Ph.D., Hirotsugu Hashimoto, M.D., Ph.D., Tao Huang, Ph.D., Aliya N. Husain, M.D., Deepali Jain, M.D., Philippe Joubert, M.D., Ph.D., Jonathan Keow, M.D., Ph.D., Andras Khoor, M,D., Ph.D., Kristine Konopka, M.D. , Ihab Lamzabi, M.D., Brandon T. Larsen, M.D., Ph.D., Lili Lee, M.D., Hui-Hua Li, M.D., Ph.D., Sherman Lin, Ana Mataić, M.D., Alex McGeough, M.D., Phillip McMullen, M.D., Ph.D., M. Ángeles Montero-Fernández, M.D., Ph.D., Jijgee Munkhdelger, M.D., Ph.D., Alexis Musick, B.S., Nya D. Nelson, M.D., Ph.D., Gheorghe-Emilian Olteanu, M.D., Ph.D., Pembe Oltulu, M.D., Erdener Özer, M.D., Ph.D., Sevilay Özmen, M.D., Nat Pernick, M.D., William Perry, M.D., M.P.H., Jennifer Pogoriler, M.D., Ph.D., Jian-Hua Qiao, M.D., Sakda Sathirareuangchai, M.D., Jefree J. Schulte, M.D., Sana Shah, M.B.B.S., Divya Sharma, M.D., Brian D. Stewart, M.D., Emily O. Symes, M.D., Anusmita Tripathy, M.D., Ateeqa Mujeeb Ullah, M.D., Caroline I.M. Underwood, M.D., Elliot Weisenberg, M.D., Roseann I. Wu, M.D., M.P.H., Y. Albert Yeh, M.D., Ph.D., Eunhee S. Yi, M.D., Akira Yoshikawa, M.D., Bahaaeldin Youssef, M.D., Paul J.L. Zhang, M.D., Fang Zhou, M.D.
Resident / Fellow Advisory Board: David B. Chapel, M.D.
Editorial Board Members: Andrey Bychkov, M.D., Ph.D., Matthew J. Cecchini, M.D., Ph.D., Carolyn Glass, M.D., Ph.D., Marc Pusztaszeri, M.D., Jefree J. Schulte, M.D., Debra L. Zynger, M.D.
Deputy Editors-in-Chief: Andrey Bychkov, M.D., Ph.D., Patricia Tsang, M.D., M.B.A., Debra L. Zynger, M.D.
Editor-in-Chief: Debra L. Zynger, M.D.

Copyright: 2003-2024, PathologyOutlines.com, Inc.

Pulm / Heart related: Jobs, Fellowships, Conferences, Cases, CME, Board Review

Related chapters: Heart, Mediastinum, Pleura & peritoneum

Editorial Board oversight: Jefree J. Schulte, M.D. (last reviewed April 2022), Andrey Bychkov, M.D., Ph.D. (last reviewed January 2021)
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Page views in 2024 to date: 29

Acute fibrinous and organizing pneumonia
Radiology images

Images hosted on other servers:
Chest radiograph Chest radiograph Chest radiograph

Chest radiograph

Acute fibrinous organizing pneumonia in left upper lobe Acute fibrinous organizing pneumonia in left upper lobe Acute fibrinous organizing pneumonia in left upper lobe

Acute fibrinous organizing pneumonia in left upper lobe


Multifocal opacities

Multifocal opacities

Before and after corticosteroid therapy Before and after corticosteroid therapy

Before and after corticosteroid therapy

Before disease onset and before / after corticoid therapy

Before disease onset and before / after corticoid therapy

Microscopic (histologic) images

Contributed by Akira Yoshikawa, M.D. and Yale Rosen, M.D.
Low power

Low power

Medium power

Medium power

High power High power

High power

Elastica van Gieson staining Elastica van Gieson staining

Elastica van Gieson staining


Fibrin balls Fibrin balls Fibrin balls Fibrin balls Fibrin balls Fibrin balls

Fibrin balls


Fibrin balls

Fibrin balls

Acute fibrinous and organizing pneumonia Acute fibrinous and organizing pneumonia Acute fibrinous and organizing pneumonia Acute fibrinous and organizing pneumonia

Acute fibrinous and organizing pneumonia



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Fibrin balls in air spaces Fibrin balls in air spaces Fibrin balls in air spaces Fibrin balls in air spaces Fibrin balls in air spaces

Fibrin balls in air spaces


Fibrin balls in air spaces Fibrin balls in air spaces

Fibrin balls in air spaces

AFOP

AFOP


Acute interstitial pneumonia
Radiology images

Images hosted on other servers:
Chest radiograph

Chest radiograph

Exudative phase on CT Exudative phase on CT

Exudative phase on CT

Organizing phase on CT Organizing phase on CT

Organizing phase on CT


Comparison on CT and histology Comparison on CT and histology

Comparison on CT and histology

Gross images

Contributed by Yale Rosen, M.D.
Gross images of diffuse alveolar damage Gross images of diffuse alveolar damage

Gross images of diffuse alveolar damage

Microscopic (histologic) images

Contributed by Akira Yoshikawa, M.D. and Yale Rosen, M.D.
Low power

Low power

Architectural destruction Architectural destruction

Architectural destruction

Fibroblastic proliferation Fibroblastic proliferation

Fibroblastic proliferation


Type II pneumocyte hyperplasia

Type II pneumocyte hyperplasia

Lymphocytic infiltration Lymphocytic infiltration

Lymphocytic infiltration

Epithelial denudation

Epithelial denudation

Dense fibrosis with smooth muscle hyperplasia

Dense fibrosis with smooth muscle hyperplasia


Organizing phase - proliferation of fibroblasts and type II pneumocytes Organizing phase - proliferation of fibroblasts and type II pneumocytes Organizing phase - proliferation of fibroblasts and type II pneumocytes Organizing phase - proliferation of fibroblasts and type II pneumocytes Organizing phase - proliferation of fibroblasts and type II pneumocytes

Organizing phase - proliferation of fibroblasts and type II pneumocytes



Images hosted on other servers:
Organizing phase

Organizing phase

Organizing phase - fibroblastic proliferation Organizing phase - fibroblastic proliferation

Organizing phase - fibroblastic proliferation

Exudative phase and organizing phase Exudative phase and organizing phase

Exudative phase and organizing phase

Cytology images

Images hosted on other servers:
Atypical epithelial cells in BAL fluid

Atypical epithelial cells in BAL fluid


Acute pneumonia
Diagrams / tables

Images hosted on other servers:

Lung immune system

Specimen handling

Organisms causing CAP

Hospitalization rate

Radiology images

Images hosted on other servers:

Lobar pneumonia

Bronchopneumonia

Bronchopneumonia


Tree in bud opacity

Necrosis and cavitation

Pneumonia, hematogenous spread

Aspiration pneumonia

Gross images

Images hosted on other servers:
Lobar pneumonia - various images Lobar pneumonia - various images

Lobar pneumonia

Bronchopneumonia - various images Bronchopneumonia - various images

Bronchopneumonia

Bronchopneumonia - various images Bronchopneumonia - various images

Bronchopneumonia


Lobar pneumonia - various images

Bronchopneumonia

Lobar pneumonia - various images

Streptococcus pneumoniae

Lobar pneumonia - various images

Staphylococcus aureus

Lobar pneumonia - various images

Streptococcus pyogenes

Lobar pneumonia - various images

Klebsiella pneumoniae

Lobar pneumonia - various images

Pseudomonas aeruginosa

Microscopic (histologic) images

Contributed by Sakda Sathirareuangchai, M.D. and Yuri Tachibana, M.D.

Intra-alveolar neutrophils

Acute bronchiolitis

Bacterial colonies

Diffuse alveolar damage

Granulomatous inflammation


Foreign body

Foreign body

Necrotizing inflammation

Alveolar exudate

Alveolar exudate

Cytology images

Images hosted on other servers:

S. pneumoniae (sputum, Gram stain)

P. aeruginosa (sputum, Gram stain)

BAL, purulent exudate

FNA, purulent exudate

FNA, gram negative bacilli

Videos

Bronchopneumonia

Lobar pneumonia


Adenocarcinoma in situ
Radiology images

Images hosted on other servers:

AIS as ground glass lesion

Gross images

Contributed by Atreyee Basu, M.D. and Fang Zhou, M.D.

Firm, tan, ill defined lesion

Microscopic (histologic) images

Contributed by Atreyee Basu, M.D. and Fang Zhou, M.D.

Neoplastic cells, lepidic pattern

Neoplastic cells, nuclear atypia

Cytology images

Contributed by Atreyee Basu, M.D. and Fang Zhou, M.D.

Nuclear irregularities and anisocytosis

Nuclear pseudoinclusions and grooves

Nuclear atypia

TTF1 immunostain

Videos

Adenocarcinoma in situ
by Dr. Thomas Colby


Adenocarcinoma overview
Diagrams / tables

Images hosted on other servers:
Histologic subtyping for surgeon

Histologic subtyping for surgeon

Histologic pattern and prognosis

Histologic pattern and prognosis

Treatment

Treatment

Grading of invasive nonmucinous adenocarcinomas

Grading of invasive nonmucinous adenocarcinomas

Radiology images

Image hosted on other servers:
Mucinous adenocarcinoma

Mucinous adenocarcinoma

Adenocarcinoma on axial CT Adenocarcinoma on axial CT

Adenocarcinoma on axial CT

Gross images

Contributed by Yale Rosen, M.D.
Peripheral adenocarcinoma

Peripheral adenocarcinoma



Images hosted on other servers:
Peripheral adenocarcinoma

Peripheral adenocarcinoma

Microscopic (histologic) images

Contributed by Caroline I.M. Underwood, M.D., Andrey Bychkov, M.D., Ph.D., Fulvio Lonardo, M.D. and Negar Rassaei, M.D.
Adenocarcinoma in situ

Adenocarcinoma in situ

Acinar pattern

Acinar pattern

Lepidic pattern, architecture

Lepidic pattern, architecture

Lepidic pattern, cytologic features

Lepidic pattern, cytologic features

Micropapillary pattern

Micropapillary pattern


Papillary pattern Papillary pattern

Papillary pattern

Papillary pattern

Papillary pattern

Solid pattern, architecture

Solid pattern, architecture

Solid pattern, cytologic features

Solid pattern, cytologic features


Mucinous subtype, architecture

Mucinous subtype, architecture

Mucinous subtype, cytologic features

Mucinous subtype, cytologic features

Positive PDL1

Negative PDL1

Negative PDL1

ADC cocktail

Cytology images

Images hosted on other servers:
Large malignant cells

Large malignant cells

Molecular / cytogenetics images

Contributed by Ankur R. Sangoi, M.D. (Case #425)
<i>ALK</i> break apart FISH images (<i>ALK</i> gene in RED) <i>ALK</i> break apart FISH images (<i>ALK</i> gene in RED)

ALK break apart FISH images


Adenoid cystic carcinoma
Radiology images

Images hosted on other servers:
Adenoid cystic carcinoma<br>obstructing right upper<br>lobar bronchus

Adenoid cystic carcinoma
obstructing right upper
lobar bronchus

Clinical images

Images hosted on other servers:
Various images

Various images

Gross images

Images hosted on other servers:
75 year old woman with 1 cm lung lesion

75 year old woman with 1 cm lung lesion

Microscopic (histologic) images

Contributed by Yale Rosen, M.D. and @ThatGlassTho on Twitter
Adenoid cystic carcinoma Adenoid cystic carcinoma Adenoid cystic carcinoma Adenoid cystic carcinoma

Adenoid cystic carcinoma

Adenoid cystic carcinoma Adenoid cystic carcinoma

Adenoid cystic carcinoma



Images hosted on other servers:
Cribriform-like structures with mucus

Cribriform-like structures with mucus

Focal tubular structure

Focal tubular structure

Various images

Various images

14 year old girl with 11 cm lung mass

14 year old girl with 11 cm lung mass


75 year old woman with 1 cm lung lesion (H&E, TTF1) 75 year old woman with 1 cm lung lesion (H&E, TTF1) 75 year old woman with 1 cm lung lesion (H&E, TTF1)

75 year old woman with 1 cm lung lesion (H&E, TTF1)

Cytology images

Images hosted on other servers:
Cytomorphology of pulmonary ACC

Cytomorphology of pulmonary adenoid cystic carcinoma


Adenosquamous
Diagrams / tables
N/A
Radiology images
N/A
Clinical images
N/A
Gross images
N/A
Microscopic (histologic) images

Contributed by Roseann Wu, M.D., M.P.H. and Yale Rosen, M.D.
Glandular and squamous features Glandular and squamous features

Glandular and squamous features

Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma

Adenosquamous carcinoma

Cytology images

Contributed by Roseann Wu, M.D., M.P.H.
Glandular and squamous features Glandular and squamous features Glandular and squamous features

Glandular and squamous features



Images hosted on other servers:
Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma

Adenosquamous carcinoma

Electron microscopy images
N/A
Molecular / cytogenetics images

Images hosted on other servers:
With <i>KRAS</i> and <i>EGFR</i> mutations

With KRAS and EGFR mutations

Videos

Metastatic adenosquamous carcinoma of the lung to wrist with squamous histology


Adenosquamous
Microscopic (histologic) images

Contributed by Roseann Wu, M.D., M.P.H. and Yale Rosen, M.D.
Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma

Adenosquamous carcinoma



Images hosted on other servers:
Transbronchial lung biopsy with adenocarcinoma and squamous cell carcinoma Transbronchial lung biopsy with adenocarcinoma and squamous cell carcinoma

Transbronchial lung biopsy with adenocarcinoma and squamous cell carcinoma

Adenocarcinoma forming mucous membranes and parts of the squamous epithelial arcinoma Adenocarcinoma forming mucous membranes and parts of the squamous epithelial carcinoma

Adenocarcinoma forming mucous membranes and parts of the squamous epithelial carcinoma

Cytology images

Images hosted on other servers:
Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma Adenosquamous carcinoma

Adenosquamous carcinoma

Molecular / cytogenetics images

Images hosted on other servers:
With <i>KRAS</i> and <i>EGFR</i> mutations

With KRAS and EGFR mutations

Videos



Adenovirus
Microscopic (histologic) images

Contributed by Elliot Weisenberg, M.D.
Adenovirus inclusions in lung from an infant chimpanzee

Adenovirus inclusions
in lung from an infant
chimpanzee



Images hosted on other servers:
Interstitial inflammation (no inclusions identifiable)

Interstitial inflammation (no inclusions identifiable)

Various images

Various images


Alectinib
Diagrams / tables

Images hosted on other servers:
Rearranged ALK signaling in NSCLC

Rearranged ALK signaling in NSCLC

Alectinib binds to tyrosine kinase

Alectinib binds to tyrosine kinase

ALK break apart probe for rearranged ALK

ALK break apart probe for rearranged ALK

Mechanisms of EML4-ALK rearrangement

Mechanisms of EML4-ALK rearrangement

Alectinib interacts with ALK P loop

Alectinib interacts with ALK P loop


Amyloidosis
Radiology images

Contributed by Tan-Lucien H. Mohammed, M.D.

Tracheobronchial amyloidosis

Airway thickening

Ground glass consolidation


Pulmonary nodular amyloidosis

Basilar gradient

Scattered nodules

Multiple nodules and cysts



Clinical images

Images hosted on other servers:

Primary endobronchial amyloidosis

Microscopic (histologic) images

Contributed by Brian D. Stewart, M.D.

Nodular deposits

Vascular deposition

Congo red

Congo red, polarized



Contributed by Andras Khoor, M.D., Ph.D.

Ossification


Diffuse septal deposition

Periarteriolar accentuation

Tracheobronchial deposition

Subepithelial deposits

Electron microscopy images

Images hosted on other servers:

Beta pleated sheet

Amyloid fibrils

Videos

Definition, historical aspects and properties

Pathogenesis and classification

Pathology, clinical features and prognosis


Anatomy
Diagrams / tables

Images hosted on other servers:
Various images Various images Various images

Various images

Gross images

Images hosted on other servers:
Various images Various images Various images

Various images

Microscopic (histologic) images
Contributed by Grigory Demyashkin, M.D.
Lung, glandular stage

Lung, glandular stage

Lung, glandular stage; top: spine

Lung, glandular stage; top: spine

Top: spine; lower left: trachea and esophagus; center: lung, glandular stage

Top: spine; lower left: trachea and esophagus; center: lung, glandular stage


ARDS / DAD
Diagrams / tables

Images hosted on other servers:
Acute phase

Acute phase

Organizing phase

Organizing phase

Radiology images

Images hosted on other servers:
Changes in ARDS

Changes in ARDS

Exudative phase Exudative phase

Exudative phase

Exudative phase Exudative phase

Exudative phase

Exudative phase

Exudative phase


Proliferative / organizing phase Proliferative / organizing phase

Proliferative / organizing phase

Fibrotic phase

Fibrotic phase

ARDS on CT

ARDS on CT

ARDS on CT

ARDS on CT

ARDS on CT

ARDS on CT

Gross images

Contributed by Yale Rosen, M.D.
Diffuse alveolar damage (DAD) Diffuse alveolar damage (DAD) Diffuse alveolar damage (DAD)

Diffuse alveolar damage (DAD)

Patchy lung involvement

Patchy lung involvement


Diffuse alveolar damage (DAD) Diffuse alveolar damage (DAD) Diffuse alveolar damage (DAD)

Diffuse alveolar damage (DAD)

Microscopic (histologic) images

Contributed by Akira Yoshikawa, M.D. and Yale Rosen, M.D.
Hyaline membrane Hyaline membrane

Hyaline membrane

Hyaline membrane Hyaline membrane

Hyaline membrane

Hyaline membrane

Hyaline membrane

Hyaline membranes and fibrin

Hyaline membranes and fibrin



Masson body

Masson body

Masson body

Masson body

Masson body

Masson body

Organizing DAD

Organizing DAD

Collagenous fibrosis

Collagenous fibrosis



Fibroblastic proliferation Fibroblastic proliferation

Fibroblastic proliferation

Fibroblastic proliferation Fibroblastic proliferation

Fibroblastic proliferation

Interstitial organization

Interstitial organization

Inflammatory cells

Inflammatory cells

Videos

Histology of DAD


Asbestosis
Gross images

Images hosted on other servers:
Pleural plaque

Pleural plaque

Microscopic (histologic) images

Contributed by Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.
Missing Image

Asbestos bodies in alveolar spaces

Missing Image

Ferruginous body

Missing Image

Asbestos body

Missing Image

Dumbbell shaped asbestos body


Aspergillus
Diagrams / tables

Images hosted on other servers:

Aspergillus life cycle

Syndromes associated with aspergillosis

Spectrum of aspergillosis

Mechanism

Radiology images

Images hosted on other servers:

ABPA, chest Xray and CT

CCPA, chest CT

CCPA, air crescent sign


IPA, chest Xray

IPA, chest CT

IPA, halo sign

Gross images

Images hosted on other servers:
Abscess

Abscess

Aspergilloma Aspergilloma

Aspergilloma

Invasive aspergillosis

Systemic invasive aspergillosis

Microscopic (histologic) images

Contributed by Sakda Sathirareuangchai, M.D., Venna Maheshwar, M.D., Kiran Alam, M.D., Anshu Jain and Claudia Mendez, M.D.
Chronic cavitary pulmonary aspergillosis Chronic cavitary pulmonary aspergillosis Chronic cavitary pulmonary aspergillosis

Chronic cavitary pulmonary aspergillosis

Allergic bronchopulmonary aspergillosis Allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis

Invasive pulmonary aspergillosis

Invasive pulmonary aspergillosis


Invasive pulmonary aspergillosis

Invasive pulmonary aspergillosis

Aspergilloma, PAS stain Aspergilloma, PAS stain

Aspergilloma, PAS stain

Fungal hyphae, PAS stain Fungal hyphae, PAS stain Fungal hyphae, GMS stain

GMS stain

Cytology images

Images hosted on other servers:

Lung FNA, granuloma

Lung FNA, Aspergillus

BAL cytology, Aspergillus

Bronchial washing, Aspergillus

Sputum, calcium oxalate crystal

Bronchial brushing, Aspergillus

Bronchial brushing, Aspergillus


Invasive aspergillus tracheobronchitis: abundant necrotic material with multiple mycelia, consisting of septate hyphae branching at 45 degrees

Lung TBNA, Aspergillus

Electron microscopy images

Images hosted on other servers:

Scanning EM, A. fumigatus

Videos

Pulmonary aspergillosis


Asthma
Gross images

Images hosted on other servers:
Mucus plugs Mucus plugs

Mucus plugs

Status asthmaticus Status asthmaticus

Status asthmaticus

Microscopic (histologic) images

Contributed by Bobbi Pritt, M.D., Neil Harris, M.D. and Stacy Beal, M.D.

Curschmann spirals



Images hosted on other servers:
Smooth muscle hypertrophy and inflammatory cells Smooth muscle hypertrophy and inflammatory cells

Smooth muscle hypertrophy and inflammatory cells

Eosinophils and Charcot-Leyden crystals

Eosinophils and Charcot-Leyden crystals

Curschmann spirals Curschmann spirals Curschmann spirals

Curschmann spirals


Atypical adenomatous hyperplasia
Radiology images

Images hosted on other servers:

Conventional TSCT

Microscopic (histologic) images

Contributed by Sherman Lin and Matthew J. Cecchini, M.D., Ph.D.

Small proliferation
of larger
hyperchromatic
cells

Proliferation of atypical pneumocytes

Discontinuous monolayer of atypical cells


Atypical carcinoid tumor / neuroendocrine tumor, grade 2
Radiology images
Clinical images

Images hosted on other servers:

Bronchial occlusion

Endobronchial tumor

Tumor near trachea

Gross images
Microscopic (histologic) images

Contributed by Philippe Joubert, M.D., Ph.D.
Peripheral carcinoid

Peripheral carcinoid

Histologic pattern: rosettes

Histologic pattern: rosettes

Histologic pattern: organoid

Histologic pattern: organoid

Histologic pattern: papillary

Histologic pattern: papillary

Histologic pattern: solid

Histologic pattern: solid

Cytologic features: salt and pepper chromatin

Cytologic features: salt and pepper chromatin


Cytologic features: spindle cell features

Cytologic features: spindle cell features

Cytologic features: eosinophilic cytoplasm

Cytologic features: eosinophilic cytoplasm

 Increased mitotic rate Increased mitotic rate

Increased mitotic rate

Necrosis (larger focus) Necrosis (larger focus)

Necrosis (larger focus)


Necrosis (punctate)

Necrosis (punctate)

Lymphovascular invasion with punctate necrosis

Lymphovascular invasion with punctate necrosis

Stroma: ossification

Stroma: ossification

AE1/3

AE1 / AE3

CD56

CD56

Chromogranin

Chromogranin


TTF1

TTF1

Ki67

Ki67

Elevated proliferation rate

Elevated proliferation rate

Cytology images

Benign metastasizing leiomyoma
Radiology images

Images hosted on other servers:

CT of benign metastasizing leiomyoma in lung

Gross images

Contributed by Roseann Wu, M.D., M.P.H.

Homogenous whorled cut surface

Microscopic (histologic) images

Contributed by Roseann Wu, M.D., M.P.H.

Well circumscribed lesion

Bland spindle cells

Cytology images

Images hosted on other servers:
FNA, large clusters of spindle shaped cells FNA, large clusters of spindle shaped cells

FNA, large clusters of spindle shaped cells

Molecular / cytogenetics images

Images hosted on other servers:

PCR amplification of lung and uterine tumors

Telomere length by FISH

Videos

Benign metastasizing leiomyoma


Biopsies
Diagrams / tables

Images hosted on other servers:

Terminology in small biopsy and cytology versus resection specimen

Small biopsy and cytologic preparation guidelines

Microscopic (histologic) images

Contributed by Phillip McMullen, M.D., Ph.D.
Lung mass Lung mass

Lung mass

TTF1

TTF1

p40

p40


Bronchiectasis
Diagrams / tables

Images hosted on other servers:

Morphological types

Different etiologies of bronchiectasis

Radiology images

Images hosted on other servers:

CT, coronal cross section

CT, axial cross section

Gross images

Contributed by Kristine Konopka, M.D.

Dilated airways with mucoid deposition

Dilated airways

Microscopic (histologic) images

Contributed by Heather I-Hsuan Chen-Yost, M.D.

Lung explanted for cystic fibrosis

Diffuse inflammation and mucus plugging

Mixed acute and chronic inflammation

Lung explanted for idiopathic pulmonary fibrosis

Features of organizing pneumonia

Videos

Histopathology: lung bronchiectasis


Bronchopulmonary dysplasia
Microscopic (histologic) images

Images hosted on other servers:
Severe fibrosis

Severe fibrosis

Large alveoli

Large alveoli


Carcinoid tumorlet
Radiology images

Contributed by Andréanne Gagné, M.D., M.Sc. and Philippe Joubert, M.D., Ph.D.
CT scan: nodules

CT scan: nodules



Images hosted on other servers:

Peribronchiolar nodules

Multiple nodules

Nodules and air trapping (DIPNECH)

Microscopic (histologic) images

Contributed by Andréanne Gagné, M.D., M.Sc. and Philippe Joubert, M.D., Ph.D.
Missing Image

Peripheral nodule

Missing Image

Poorly delineated nodule

Missing Image

Tumorlet

Missing Image

Tumorlet arising in DIPNECH

Missing Image

Small tumorlet


Missing Image

Clear cell features

Missing Image

Spindle cell features

Missing Image

Salt and pepper chromatin

Missing Image

CD56


Carcinosarcoma
Radiology images

Images hosted on other servers:
CT before / after targeted therapy CT before / after targeted therapy CT before / after targeted therapy

CT before / after targeted therapy

Large mass on CT scan

Large mass on CT scan

Mass lesion located left hilar localization

Mass lesion located left hilar localization

Gross images

Images hosted on other servers:
Bronchial carcinosarcoma

Bronchial carcinosarcoma

Microscopic (histologic) images
Scroll to see all images


Contributed by Yale Rosen, M.D. and Jian-Hua Qiao, M.D.
Giant cell carcinoma Giant cell carcinoma Giant cell carcinoma Giant cell carcinoma Giant cell carcinoma

Giant cell carcinoma

Core biopsy

Core biopsy


AE1 / AE3

AE1 / AE3

Cam 5.2

CAM 5.2



Images hosted on other servers:
Various images Various images Various images Various images

Various images

Initially presenting as invasive aspergillosis

Initially presenting as invasive aspergillosis

Blastomatoid variant

Blastomatoid variant


Lung parenchyma showing infiltration

Lung parenchyma showing infiltration

Lipoblastic elements with spindle cell component

Lipoblastic elements with spindle cell component

Adenocarcinoma with acinar growth pattern

Adenocarcinoma with acinar growth pattern

Malignant poorly formed epithelial glands

Malignant poorly formed epithelial glands

S100

S100

CK7 and TTF1

CK7 and TTF1


Carcinoma with atypical glands

Carcinoma with atypical glands

H&E

H&E

Cytology images

Contributed by Jian-Hua Qiao, M.D.
Highly pleomorphic giant cells Highly pleomorphic giant cells Highly pleomorphic giant cells Highly pleomorphic giant cells Highly pleomorphic giant cells Highly pleomorphic giant cells

Highly pleomorphic giant cells


Highly pleomorphic giant cells Highly pleomorphic giant cells Highly pleomorphic giant cells

Highly pleomorphic giant cells


Chronic bronchitis
Microscopic (histologic) images

Images hosted on other servers:
Mucosal glandular hyperplasia

Mucosal glandular hyperplasia

Chronic inflammatory infiltrate

Chronic inflammatory infiltrate


CMV
Microscopic (histologic) images

Contributed by Dr. Michael P. Orejudos and Dr. Rosemarie Rodriguez


Coal workers' pneumoconiosis
Radiology images

Contributed by @Andrew_Fltv on Twitter
Coal workers' pneumoconiosis

Coal workers' pneumoconiosis

Gross images

Contributed by @Andrew_Fltv on Twitter
Coal workers' pneumoconiosis Coal workers' pneumoconiosis Coal workers' pneumoconiosis

Coal workers' pneumoconiosis

Microscopic (histologic) images

Contributed by @Andrew_Fltv on Twitter
Coal workers' pneumoconiosis Coal workers' pneumoconiosis Coal workers' pneumoconiosis Coal workers' pneumoconiosis

Coal workers' pneumoconiosis


Coal workers' pneumoconiosis Coal workers' pneumoconiosis Coal workers' pneumoconiosis Coal workers' pneumoconiosis

Coal workers' pneumoconiosis



Images hosted on other servers:
Coal workers' pneumoconiosis

Coal workers' pneumoconiosis


Coccidioides
Diagrams / tables

Images hosted on other servers:
Endemic areas

Endemic areas

Endemic areas

Coccidioides spp. life cycle

Microscopic (histologic) images

Contributed by Sakda Sathirareuangchai, M.D.
Spherules

Spherules

Spherule

Spherule

Spherules GMS

Spherules GMS

Cytology images

Contributed by Sakda Sathirareuangchai, M.D.
Spherule cytologic smear

Spherule cytologic smear

Videos

Dimorphic fungi: coccidioidomycosis by Glenn D. Roberts, Ph.D.


Colloid
Radiology images

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Radiological evaluation

Radiological evaluation

Radiology and bronchoscopy

Radiology and bronchoscopy

Clinical images

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Intraoperative view of white mass with indistinct margins

Intraoperative view
of white mass
with indistinct
margins

Intraoperative view of giant cystic colloid adenocarcinoma

Intraoperative
view of giant
cystic colloid
adenocarcinoma

Gross images

Contributed by Matthew J. Cecchini, M.D., Ph.D.
Gross cut surface

Gross cut surface



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Gross cut surface

Gross cut surface

Cystic lesion with mucin pooling

Cystic lesion with mucin pooling

Microscopic (histologic) images

Contributed by Gheorghe-Emilian Olteanu, M.D., Ph.D., Ana Mataić, M.D. and Luka Brčić, M.D., Ph.D.
Abundant extracellular mucin

Abundant extracellular mucin

Mucin laden cells

Mucin laden cells

Hypercellularity

Hypercellularity

Inflammatory infiltrate

Inflammatory infiltrate

Nuclear and cytoplasm detail

Nuclear and cytoplasm detail


Siderophages and colloid adenocarcinoma cells

Siderophages and colloid adenocarcinoma cells

Extensive extracellular mucin

Extensive extracellular mucin

CK20 IHC stain

CK20 IHC stain

CDX2 IHC stain

CDX2 IHC stain

CK7 IHC stain

CK7 IHC stain

Cytology images

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Clusters of cells with basally oriented nuclei

Clusters of cells with basally oriented nuclei


Congenital pulmonary airway malformation (CPAM)
Gross images

Contributed by Nya D. Nelson, M.D., Ph.D. and Jennifer Pogoriler, M.D., Ph.D.
Type 1 CPAM

Type 1 CPAM

Type 2 CPAM

Type 2 CPAM

Type 3 CPAM

Type 3 CPAM


Microscopic (histologic) images

Contributed by Nya D. Nelson, M.D., Ph.D. and Jennifer Pogoriler, M.D., Ph.D.
Type 1 CPAM low power

Type 1 CPAM

Type 1 CPAM complexity

Type 1 CPAM complexity

Mucinous cell clusters

Mucinous cell clusters

Small mucinous cell cluster

Small mucinous cell cluster

Type 2 CPAM low power Type 2 CPAM

Type 2 CPAM


Type 2 CPAM - mucostasis

Type 2 CPAM - mucostasis

Congenital lobar emphysema low power Congenital lobar emphysema

Congenital lobar emphysema

Type 3 CPAM low power Type 3 CPAM

Type 3 CPAM


COVID-19
Diagrams / tables

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SARS-CoV-2

Pathogenesis of COVID-19

Epidemic timeline of COVID-19


Timeline of tissue changes

Timeline of autopsy studies

Autopsy PPE

Radiology images

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Chest CT images

Severe changes

Gross images

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Grossing protocol

Thickened alveolar septa, thromboemboli

Patchy consolidations

Subsegmental pulmonary embolism

Microscopic (histologic) images

Contributed by Toru Igari, M.D., Jin Takahashi, M.D. and Shinyu Izumi, M.D.
Bronchial change

Bronchial change

Squamous metaplasia

Squamous metaplasia

Acute phase

Acute phase

Hyaline membranes

Hyaline membranes

Organizing phase

Organizing phase


Organizing phase Organizing phase

Organizing phase

Organizing phase Organizing phase

Organizing phase

Fibroblastic proliferation

Fibroblastic proliferation


Lymphocytic infiltration

Lymphocytic infiltration

Pneumocyte hyperplasia Pneumocyte hyperplasia Pneumocyte hyperplasia

Pneumocyte hyperplasia

Epithelial denudation

Epithelial denudation


Epithelial denudation

Epithelial denudation

Perivascular lymphocytes

Perivascular lymphocytes

Clear cell change

Clear cell change

Multinucleation Multinucleation

Multinucleation



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Lung injury patterns


SARS-CoV-2 in lung

Cytology images

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Inflammatory background

Nuclear, cytoplasmic inclusion


Multinucleated alveolar macrophage

Multinucleated giant cell

BAL ThinPrep

Electron microscopy images

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Scanning electron microscopy

Transmission electron microscopy

Virus in epithelial cells

Videos

Pathology of COVID-19: a pulmonary pathologist explains

Sample management

Autopsy


SARS-CoV-2 detection in tissues

Pulmonary pathology

Cardiovascular pathology


COVID-19 autopsy pathology findings

Histology of acute respiratory distress syndrome


Cystic fibrosis
Diagrams / tables

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CFTR CFTR

CFTR


Desquamative interstitial pneumonitis
Radiology images

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High resolution CT High resolution CT High resolution CT

High resolution CT

Microscopic (histologic) images

Contributed by Akira Yoshikawa, M.D.
Low power

Low power

Middle power Middle power

Middle power

Smoker's macrophages Smoker's macrophages

Smoker's macrophages


Giant cells

Giant cells

Lymphoid follicles

Lymphoid follicles

Low power

Low power

Middle power Middle power

Middle power


Smoker's macrophages and interstitial fibrosis Smoker's macrophages and interstitial fibrosis Smoker's macrophages and interstitial fibrosis

Smoker's macrophages and interstitial fibrosis



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Trichrome staining

Trichrome staining

H&E and IHC of CD68

H&E and IHC of CD68

Electron microscopy images

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Numerous lysosomes in macrophages Numerous lysosomes in macrophages Numerous lysosomes in macrophages

Numerous lysosomes in macrophages

Videos

Histopathology Lung - Desquamative interstitial pneumonia


Diffuse idiopathic pulmonary neuroendocrine hyperplasia
Radiology images

Contributed by Andréanne Gagné, M.D., M.Sc. and Philippe Joubert, M.D., Ph.D.
CT scan: mosaic perfusion

CT scan:
mosaic perfusion

CT scan: nodules

CT scan: nodules

Microscopic (histologic) images

Contributed by Andréanne Gagné, M.D., M.Sc. and Philippe Joubert, M.D., Ph.D.
Small nodules

Small nodules

Linear proliferation

Linear proliferation

Nodule occluding a bronchiole

Nodule occluding a bronchiole

Discrete proliferation

Discrete proliferation

Tumorlet

Tumorlet


Tumorlet

Tumorlet

Salt and pepper chromatin

Salt and pepper chromatin

Chromogranin

Chromogranin

Synaptophysin

Synaptophysin

CD56

CD56


Diffuse pulmonary lymphangiomatosis
Radiology images
  • Xray: nonspecific findings, including pleural effusion, diffuse pulmonary opacities, interstitial thickening
  • CT: bilateral ground-glass opacities, smooth thickening of interlobular septa, bronchovascular bundles, pleura; may show infiltration of the mediastinal soft tissue by cystic fluid densities
  • Radiology images

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    Lower lung heterogeneous opacities

    Lower lung heterogeneous opacities

    Thickening with effusions

    Thickening with effusions

    Clinical images

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    Subpleural lymphatic vessels

    Subpleural lymphatic vessels

    Microscopic (histologic) images

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    D2-40

    D2-40

    Native lung

    Native lung

    Multiple proliferating vascular spaces

    Multiple proliferating vascular spaces


    Emphysema
    Diagrams / tables

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    Components of COPD

    Classification of emphysema

    High resolution CT diagram

    Radiology images

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    Centriacinar emphysema

    Centriacinar emphysema

    Panacinar emphysema

    Paraseptal (distal acinar) emphysema


    Interstitial emphysema

    CPFE

    AATD

    Gross images

    Images hosted on other servers:

    Centriacinar emphysema

    Centriacinar emphysema

    Panacinar emphysema


    Paraseptal (distal acinar) emphysema

    Centriacinar versus panacinar emphysema

    Cystic formation from alveolar wall destruction

    Lung bullae

    "Dirty holes" in subtle emphysema


    Combined emphysema and fibrosis

    Microscopic (histologic) images

    Contributed by Akira Yoshikawa, M.D.
    Normal lung architecture

    Normal lung architecture

    Peribronchiolar region

    Peribronchiolar region

    Centriacinar involvement Centriacinar involvement Centriacinar involvement

    Centriacinar involvement

    Panacinar emphysema

    Panacinar emphysema


    Paraseptal emphysema

    Paraseptal emphysema

    Electron microscopy images

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    Remodeling of elastin and collagen

    Videos

    Emphysema histology

    Emphysema classification


    Enteric
    Radiology images

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    Right upper lobe and mediastinal lymph node metastasis

    Right upper lobe
    and mediastinal
    lymph node
    metastasis

    Tumor in the lower lobe of the left lung

    Tumor in the lower lobe of the left lung

    Microscopic (histologic) images

    Contributed by Sevilay Özmen, M.D. and Pembe Oltulu, M.D.

    Moderately differentiated glands with necrotic debris

    Cribriform and acinar growth pattern

    Glands filled with necrotic debris

    Cribriform growth pattern

    Cribriform growth pattern

    Glands filled with necrotic debris

    Glands filled with necrotic debris


    CK7 positivity CK7 positivity

    CK7 positivity

    CK20 positivity CK20 positivity

    CK20 positivity

    CDX2 positivity

    CDX2 positivity

    TTF1 positivity

    TTF1 positivity

    Cytology images

    Contributed by Sevilay Özmen, M.D.

    Small clumps of tumor cells

    Cluster of tumor cells

    Cluster of tumor cells

    Papillary cluster

    Papillary cluster

    Acinar cluster

    Acinar cluster


    Eosinophilic pneumonia
    Microscopic (histologic) images

    Case #105

    Acute eosinophilic pneumonia


    Epithelial myoepithelial carcinoma
    Radiology images

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    Chest Xray and<br>CT of peripheral nodule

    Chest Xray and
    CT of peripheral nodule

    Clinical images

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    Bronchoscopy with lobulated<br>endobronchial mass

    Bronchoscopy with lobulated
    endobronchial mass

    Gross images

    Images hosted on other servers:
    Incidental endobronchial mass

    Incidental endobronchial mass

    Peripheral tumor

    Peripheral tumor

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H. and Case #357
    Epithelial myoepithelial carcinoma arising from airway Epithelial myoepithelial carcinoma arising from airway

    Epithelial myoepithelial carcinoma arising from airway

    Lung biopsy Lung biopsy Lung biopsy Lung biopsy

    Lung biopsy


    Lung biopsy

    Lung biopsy



    Images hosted on other servers:
    Tumor with tubular and<br>glandular structures

    Tumor with tubular and
    glandular structures

    Incidental endobronchial mass - H&E Incidental endobronchial mass - H&E

    Incidental endobronchial mass - H&E

    Incidental endobronchial mass - calponin

    Incidental endobronchial mass - calponin

    Incidental endobronchial mass - S100

    Incidental endobronchial mass - S100

    Incidental endobronchial mass - AE1 / AE3

    Incidental endobronchial mass - AE1 / AE3


    Incidental endobronchial mass - CK7

    Incidental endobronchial mass - CK7

    Incidental endobronchial mass - CK903

    Incidental endobronchial mass - CK903

    Incidental endobronchial mass - Ki67

    Incidental endobronchial mass - Ki67


    Fetal
    Microscopic (histologic) images

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    Well differentiated tumor Well differentiated tumor Well differentiated tumor

    Well differentiated tumor

    Cytology images

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    Various images

    Various images


    Granulomatosis with polyangiitis (GPA)
    Radiology images

    Images hosted on other servers:

    Multiple nodules and ground glass opacities

    Large bilateral pulmonary cavities

    Gross images

    Contributed by Yale Rosen, M.D. and Philip Kane, M.D.
    Nodules with central cavitation

    Nodules with central cavitation

    Solid nodule

    Solid nodule

    Solid nodule with areas of cavitation

    Solid nodule with areas of cavitation

    Microscopic (histologic) images

    Contributed by Matthew J. Cecchini, M.D., Ph.D.
    Blue (dirty) necrosis

    Blue (dirty) necrosis

    Geographic necrosis

    Geographic necrosis

    Blue (dirty) necrosis in core needle biopsy

    Blue (dirty) necrosis in core needle biopsy

    Granulomatous inflammation Granulomatous inflammation

    Granulomatous inflammation


    Vasculitis

    Vasculitis

    Focal vasculitis

    Focal vasculitis

    Small vessel vasculitis

    Small vessel vasculitis

    Hyperchromatic giant cells

    Hyperchromatic giant cells

    Capillaritis

    Capillaritis

    Videos

    Granulomatosis with polyangiitis (pathophysiology, symptoms, treatment)

    GPA symptoms, diagnosis, treatment


    GPA review

    GPA discussion at 5:01


    Herpes simplex
    Gross images

    Contributed by Yale Rosen, M.D.
    Various images Various images

    Various images

    Microscopic (histologic) images

    Images hosted on other servers:
    Immunostain highlights<br>HSV+ cell in<br>broncheo-alveolar lavage

    Immunostain highlights
    HSV+ cell in
    broncheo-alveolar lavage


    Histology
    Gross images

    Contributed by Hirotsugu Hashimoto, M.D., Ph.D.

    Cut surface of the lung

    Microscopic (histologic) images

    Contributed by Hirotsugu Hashimoto, M.D., Ph.D.

    Bronchovascular bundle

    Bronchial wall

    Miller's secondary lung lobule

    Miller's secondary lung lobule (elastica Masson)

    Peripheral airway (bronchiole to alveoli)

    Alveoli

    Electron microscopy images

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    Type II alveolar epithelium (pneumocyte)


    Histoplasma
    Microscopic (histologic) images

    Contributed by Jamie Shutter, M.D.
    Left images: H&E; right images: GMS Left images: H&E; right images: GMS

    H&E

    Left images: H&E; right images: GMS Left images: H&E; right images: GMS

    GMS



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    GMS staining

    GMS staining


    HIV
    Microscopic (histologic) images

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    CMV and pulmonary alveolar proteinosis


    Hyalinizing clear cell carcinoma
    Diagrams / tables
    No information provided
    Radiology images

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    Lobulated mass in right lower lobe of lung

    Lobulated mass in right lower lobe of lung

    Solitary, noncalcified nodule in left lower lobe

    Solitary, noncalcified nodule in left lower lobe

    Preoperative CT of pulmonary HCCC

    Preoperative CT of pulmonary HCCC

    Clinical images

    Images hosted on other servers:
    Intrabronchial protrusion of mass

    Intrabronchial protrusion of mass

    Bronchoscopy of pulmonary HCCC and SCC

    Bronchoscopy of pulmonary HCCC and SCC

    Gross images

    Images hosted on other servers:
    Well demarcated, creamy white intrabronchial mass

    Well demarcated,
    creamy white
    intrabronchial
    mass

    Solid, white and well demarcated lung mass

    Solid, white and well demarcated lung mass

    Microscopic (histologic) images

    Contributed by Aliya N. Husain, M.D.
    Nest, trabeculae and glandular pattern

    Nest, trabeculae and glandular pattern

    Monomorphic tumor cells

    Monomorphic tumor cells

    Hyalinized stroma

    Hyalinized stroma

    Inconspicuous nucleoli

    Inconspicuous nucleoli


    Clear to eosinophilic cytoplasm

    Clear to eosinophilic cytoplasm

    Stroma is densely hyalinized

    Stroma is densely hyalinized

    p40 nuclear positivity

    p40 nuclear positivity

    Cytoplasmic positivity with AE1 / AE3 immunostain

    Cytoplasmic positivity with AE1 / AE3 immunostain

    Cytology images
    N/A
    Electron microscopy images
    N/A
    Molecular / cytogenetics images

    Images hosted on other servers:
    Detection of <i>EWSR1::ATF1</i>

    Detection of EWSR1::ATF1

    Videos
    No information provided

    Hypersensitivity pneumonitis
    Radiology images

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    Chest X-ray and CT image of HP

    Chest X-ray and CT image of HP

    CT of HP

    CT of HP

    CT of acute HP due to isocyanate

    CT of acute HP due to isocyanate

    CT of subacute HP of a farmer

    CT of subacute HP of a farmer

    CT of chronic HP of a plastic industrial worker

    CT of chronic HP of a plastic industrial worker

    CT of HP due to nontuberculous mycobacterium

    CT of HP due to nontuberculous mycobacterium

    Microscopic (histologic) images

    Scroll to see all images:

    Contributed by Akira Yoshikawa, M.D.
    Case 1: 69 year old woman with history of exposure to bird antigen Case 1: 69 year old woman with history of exposure to bird antigen Case 1: 69 year old woman with history of exposure to bird antigen Case 1: 69 year old woman with history of exposure to bird antigen Case 1: 69 year old woman with history of exposure to bird antigen Case 1: 69 year old woman with history of exposure to bird antigen

    Case 1: 69 year old woman with history of exposure to bird antigen


    Case 2: 67 year old man with history of exposure to garden chemicals Case 2: 67 year old man with history of exposure to garden chemicals Case 2: 67 year old man with history of exposure to garden chemicals Case 2: 67 year old man with history of exposure to garden chemicals Case 2: 67 year old man with history of exposure to garden chemicals Case 2: 67 year old man with history of exposure to garden chemicals

    Case 2: 67 year old man with history of exposure to garden chemicals


    Case 2: 67 year old man with history of exposure to garden chemicals Case 2: 67 year old man with history of exposure to garden chemicals

    Case 2: 67 year old man with history of exposure to garden chemicals

    Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter

    Case 3: 72 year old male woodcutter


    Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter Case 3: 72 year old male woodcutter

    Case 3: 72 year old male woodcutter



    Images hosted on other servers:
    Airway centered lymphocytic infiltration with granuloma Airway centered lymphocytic infiltration with granuloma Airway centered lymphocytic infiltration with granuloma

    Airway centered lymphocytic infiltration with granuloma

    Airway centered lymphocytic infiltration with fibrosis

    Airway centered lymphocytic infiltration with fibrosis

    Poorly formed granulomas Poorly formed granulomas

    Poorly formed granulomas


    Poorly formed granulomas Poorly formed granulomas

    Poorly formed granulomas

    Peribronchiolar metaplasia

    Peribronchiolar metaplasia

    Intra-alveolar fibrindeposition

    Intra-alveolar fibrindeposition

    Giant cells

    Giant cells


    Comparison of<br>granulomatous lesions<br>of different diseases

    Comparison of
    granulomatous lesions
    of different diseases

    Cytology images

    Images hosted on other servers:
    Bronchoalveolar lavage fluid

    Bronchoalveolar lavage fluid


    Hypoplasia
    Gross images

    Images hosted on other servers:
    Severe pulmonary hypoplasia Severe pulmonary hypoplasia

    Severe pulmonary hypoplasia


    Infantile lobar emphysema
    Microscopic (histologic) images

    Images hosted on other servers:
    Various images Various images

    Various images


    Infarct / pulmonary emboli
    Diagrams / tables

    Images hosted on other servers:

    Pathophysiology of hemodynamic instability

    Radiology images

    Images hosted on other servers:

    Saddle PE on CTA

    Gross images

    Contributed by Aliya N. Husain, M.D. and @yro854 on Twitter
    Pulmonary thromboembolism Pulmonary thromboembolism

    Pulmonary thromboembolism

    Infarct / pulmonary emboli

    Infarct / pulmonary emboli



    Images hosted on other servers:
    Thromboemboli in pulmonary artery Thromboemboli in pulmonary artery Thromboemboli in pulmonary artery

    Thromboemboli in pulmonary artery

    Saddle embolus

    Saddle embolus


    Hemorrhagic infarct

    Hemorrhagic infarct

    Organizing infarct

    Organizing infarct

    Fibrous band

    Fibrous band

    Microscopic (histologic) images

    Contributed by Aliya N. Husain, M.D.
    Lines of Zahn

    Lines of Zahn

    Postmortem clot

    Postmortem clot

    Organizing thrombus

    Organizing thrombus

    Organized thromboembolism

    Organized
    thromboembolism


    Organized thromboembolism

    Organized
    thromboembolism

    Recanalized thromboembolism

    Recanalized
    thromboembolism

    Organized thrombus

    Bone marrow embolism

    Bone marrow embolism


    Inflammatory myofibroblastic tumor
    Clinical images

    Images hosted on other servers:
    Bronchoscopy with biopsy

    Bronchoscopy with biopsy

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.



    Images hosted on other servers:
    Various images

    Myofibroblasts with plump oval nuclei

    Various images

    Lymphoid hyperplasia and lymphocytic infiltration

    Various images

    Nodular lesions and infiltrating lymphocytes

    Variable appearance of ALK<br>rearranged IMTs

    Variable appearance of ALK rearranged IMTs


    Influenza
    Microscopic (histologic) images

    Contributed by Dr. K.V. Vinu Balraam
    Lung Lung Lung Lung

    Lung

    Pulmonary lymph node

    Pulmonary lymph node

    Kidney

    Kidney


    Interstitial pneumonia with autoimmune features
    Radiology images

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    NSIP pattern on CT NSIP pattern on CT NSIP pattern on CT NSIP pattern on CT

    NSIP pattern on CT


    OP pattern on CT OP pattern on CT

    OP pattern on CT

    LIP pattern on CT

    LIP pattern on CT

    Clinical images

    Images hosted on other servers:

    Clinical features in systemic sclerosis
    Digital ulceration Digital ulceration

    Digital ulceration

    Telangiectasia Telangiectasia

    Telangiectasia


    Raynaud's phenomenon

    Raynaud's phenomenon
    and telangiectasia



    Clinical features in dermatomyositis

    Mechanic hand

    Gottron's sign

    Microscopic (histologic) images

    Contributed by Akira Yoshikawa, M.D.
    Low power

    Low power

    NSIP pattern

    NSIP pattern

    Lymphoplasmacytic infiltration without lymphoid follicles Lymphoplasmacytic infiltration without lymphoid follicles

    Lymphoplasmacytic infiltration without lymphoid follicles

    Pleural thickening and pleuritis Pleural thickening and pleuritis

    Pleural thickening and pleuritis


    Vascular wall thickening

    Vascular wall thickening

    Emphysematous change

    Emphysematous change

    Low power

    Low power

    UIP pattern

    UIP pattern

    Lymphoid follicles with germinal centers

    Lymphoid follicles with germinal centers

    Honeycomb change

    Honeycomb change


    Honeycomb change

    Honeycomb change

    Lymphoplasmacytic infiltration

    Lymphoplasmacytic infiltration

    Dense fibrosis with lymphocytic infiltration Dense fibrosis with lymphocytic infiltration

    Dense fibrosis with lymphocytic infiltration



    Also see: NSIP


    Images hosted on other servers:
    NSIP pattern NSIP pattern NSIP pattern

    NSIP pattern

    OP pattern OP pattern OP pattern

    OP pattern


    OP pattern

    OP pattern

    LIP pattern LIP pattern LIP pattern LIP pattern

    LIP pattern


    Intravenous drug abusers
    Microscopic (histologic) images

    Images hosted on other servers:
    Polarized light

    Polarized light


    Invasive mucinous
    Diagrams / tables

    Images hosted on other servers:
    Survival curves

    Survival curves

    Radiology images

    Images hosted on other servers:
    Computed tomography Computed tomography Computed tomography Computed tomography Computed tomography Computed tomography

    Computed tomography

    Gross images

    Contributed by Akira Yoshikawa, M.D. and Yale Rosen, M.D.
    Invasive mucinous adenocarcinoma Invasive mucinous adenocarcinoma

    Invasive mucinous adenocarcinoma

    Invasive, diffuse

    Invasive, diffuse

    Lepidic growth pattern

    Lepidic growth pattern

    Microscopic (histologic) images

    Contributed by Akira Yoshikawa, M.D.

    Intraalveolar mucin

    Nodules with fibrosis

    Tumor periphery

    Diffuse spread

    Acinar growth pattern


    Admixed pneumocytes

    Abundant apical mucin

    Extracellular and apical mucin

    HNF4α

    TTF1 / Napsin A



    Contributed by @zaalruwai83 on Twitter
    Invasive mucinous adenocarcinoma Invasive mucinous adenocarcinoma Invasive mucinous adenocarcinoma Invasive mucinous adenocarcinoma

    Invasive mucinous adenocarcinoma

    Cytology images

    Contributed by Takashi Hori, C.T. and Akira Yoshikawa, M.D.

    Cluster of tumor cells

    Gold mucin

    Papillary cluster


    Langerhans cell histiocytosis
    Gross images

    Images hosted on other servers:
    Tiny nodules

    Tiny nodules

    Microscopic (histologic) images

    Images hosted on other servers:
    Microcystic change

    Microcystic change

    End stage Langerhans

    End stage Langerhans

    Kidney bean shaped nuclei

    Kidney bean shaped nuclei

    CD1a+

    CD1a+

    CD1a, CD56, S100

    CD1a, CD56, S100

    Electron microscopy images

    Images hosted on other servers:
    Birbeck granules

    Birbeck granules

    Binucleated Langerhans cells, orbit

    Binucleated Langerhans cells, orbit


    Large cell
    Gross images

    Contributed by Debra L. Zynger, M.D.
    Right lung mass

    Right lung mass

    Microscopic (histologic) images

    Contributed by Emily O. Symes, M.D.

    Sheets of tumor cells

    Necrosis and lymphovascular invasion

    Extensive necrosis

    Lymphovascular invasion

    Spread through air spaces (STAS)


    High power tumor cells

    TTF1

    CK5/6

    p40

    Napsin A


    PDL1

    Mucin stain


    Large cell neuroendocrine carcinoma
    Gross images

    Contributed by Roseann Wu, M.D., M.P.H.
    Peripheral LCNEC

    Peripheral LCNEC

    Microscopic (histologic) images

    Contributed by Ioanna Abba Nteka, M.D., Aggeliki Cheva, M.D., Ph.D., Antonia Loukousia, M.D., Roseann Wu, M.D., M.P.H. and Kyriakos Chatzopoulos, M.D., Ph.D.
    Nesting, peripheral palisading, necrosis

    Nesting, peripheral palisading, necrosis

    Nuclear pleomorphism, prominent nucleoli, mitosis

    Nuclear pleomorphism, prominent nucleoli, mitosis

    Solid and nested architecture

    Solid and nested architecture

    Vascular invasion

    Vascular invasion


    Cytokeratin

    Cytokeratin

    CD56

    CD56

    Synaptophysin

    Synaptophysin

    Chromogranin

    Chromogranin

    Cytology images

    Images hosted on other servers:

    Nuclear pleomorphism with prominent nucleoli (Pap)

    Peripheral palisading
    (Diff-Quik)

    Rosette-like structure
    (Diff-Quik)


    Legionella
    Microscopic (histologic) images

    Images hosted on other servers:
    Gram stain

    Gram stain

    Immunofluorescence staining

    Immunofluorescence staining

    Cytology images

    Images hosted on other servers:
    Impression smear from lung

    Impression smear from lung

    Electron microscopy images

    Images hosted on other servers:
    Legionella pneumophila

    Legionella pneumophila


    Lepidic adenocarcinoma
    Radiology images

    Images hosted on other servers:

    Ground glass opacity

    Microscopic (histologic) images

    Contributed by Jonathan Keow, M.D., Ph.D. and Matthew J. Cecchini, M.D., Ph.D.
    Low power of lepidic adenocarcinoma

    Lepidic growth pattern

    Medium power of lepidic adenocarcinoma

    With uninvolved lung parenchyma

    High power of lepidic adenocarcinoma with focal invasion

    Lepidic adenocarcinoma with focal invasion

    Noninvasive lepidic adenocarcinoma

    Noninvasive lepidic adenocarcinoma

    High power of lepidic adenocarcinoma with focal invasion

    Lepidic adenocarcinoma

    High power of lepidic adenocarcinoma with focal invasion

    Lepidic adenocarcinoma in a background of emphysema


    Lipoid pneumonia
    Gross images

    Images hosted on other servers:
    Yellow cut surface

    Yellow cut surface

    Microscopic (histologic) images

    Case #287




    Images hosted on other servers:
    Aspiration pneumonia

    Aspiration pneumonia

    Foamy macrophages in alveolar spaces

    Foamy macrophages in alveolar spaces


    Lipoma
    Clinical images

    Images hosted on other servers:
    Endoscopy Endoscopy

    Endoscopy

    Gross images

    Images hosted on other servers:
    Complete encapsulation

    Complete encapsulation

    Microscopic (histologic) images

    Images hosted on other servers:
    Atypical lipoma Atypical lipoma

    Atypical lipoma

    Mature adipose tissue

    Mature adipose tissue


    Lymphangioleiomyomatosis
    Radiology images

    Images hosted on other servers:
    Computed tomography Computed tomography

    Computed tomography

    Gross images

    Images hosted on other servers:
    Multiple cysts

    Multiple cysts

    Microscopic (histologic) images

    Contributed by Roseann I. Wu, M.D., M.P.H. and Yale Rosen, M.D.

    Cystic lung with nodule

    Multiple cysts

    Multiple cysts

    Cytology images

    Images hosted on other servers:
    Outer flattened cells

    Outer flattened cells

    SMA, HMB45, D20

    SMA, HMB45, D2-40

    Electron microscopy images

    Images hosted on other servers:
    Multiple cysts Multiple cysts

    Type II pneumocytes in LAM nodule

    Videos

    Virtual slide review of a case of lymphangioleiomyomatosis

    Overview of radiographic features of lymphangioleiomyomatosis


    Lymphoepithelial carcinoma
    Radiology images

    Images hosted on other servers:

    Xray and CT scans

    Unenhanced thoracic CT

    Microscopic (histologic) images

    Contributed by Heather I-Hsuan Chen-Yost, M.D.

    Lymphoid-like lesion

    Lymphoid infiltrate and syncytial cells

    EBER ISH stain

    p63 immunostain

    CK5/6 immunostain


    Lymphoepithelioma-like
    Radiology images

    Images hosted on other servers:
    Various images Various images

    Various images

    Gross images

    Images hosted on other servers:
    Excised mass

    Excised mass

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.
    Syncytial growth of monomorphous, polygonal epithelial cells Syncytial growth of monomorphous, polygonal epithelial cells

    Syncytial growth of monomorphous, polygonal epithelial cells

    EBER+

    EBER+



    Images hosted on other servers:
    Various images Various images Various images Various images

    Various images


    Various images Various images Various images

    Various images


    Lymphoid interstitial pneumonia
    Radiology images

    Images hosted on other servers:
    Ground glass opacity with cyst formation and nodules

    Ground glass opacity with cyst formation and nodules

    Microscopic (histologic) images

    Contributed by Akira Yoshikawa M.D. and Yale Rosen, M.D.
    Low power

    Low power

    Bronchovascular bundle

    Bronchovascular bundle

    Architectural destruction

    Architectural destruction

    Septal thickening

    Septal thickening

    Massive lymphocytic infiltration

    Massive lymphocytic infiltration

    Giant cells and lymphocytes

    Giant cells and lymphocytes


    Lymphocytes and histiocytes

    Lymphocytes and histiocytes

    Granuloma and lymphocytes

    Granuloma and lymphocytes

    Lymphoid aggregate and histiocytes

    Lymphoid aggregate and histiocytes

    Diffuse cellular pattern

    Diffuse cellular pattern

    Lymphoplasmacytic infiltration

    Lymphoplasmacytic infiltration


    Lymphoplasmacytic infiltration Lymphoplasmacytic infiltration

    Lymphoplasmacytic infiltration



    Images hosted on other servers:
    LIP

    LIP

    Numerous lymphoid follicles Numerous lymphoid follicles

    Numerous lymphoid follicles

    EBV related LIP

    EBV related LIP


    Malakoplakia
    Gross images

    Images hosted on other servers:
    Grayish white, ill<br>defined lesion with<br>central cavitation

    Grayish white, ill
    defined lesion with
    central cavitation

    Microscopic (histologic) images

    Images hosted on other servers:
    Various images Various images

    Various images


    Measles
    Microscopic (histologic) images

    Images hosted on other servers:
    Giant cells

    Giant cells

    Videos


    Histopathology Lung - Measles pneumonia

    Metastases
    Radiology images

    Contributed by Fulvio Lonardo, M.D.
    Pancreas: adenocarcinoma

    Pancreas: adenocarcinoma



    Images hosted on other servers:
    Malignant melanoma<br>shows pulmonary<br>nodules

    Malignant melanoma
    shows pulmonary
    nodules

    Multiple round nodules and masses in both lungs

    Multiple round nodules and masses in both lungs

    Cannonball lung metastases in patient with colon cancer

    Cannonball lung metastases in patient with colon cancer

    Multiple lung metastases

    Multiple lung metastases

    Gross images

    Contributed by Roseann Wu, M.D., M.P.H.
    Lung wiht metastatic tumor

    Lung with metastatic tumor



    Images hosted on other servers:
    Multiple tumor nodules Multiple tumor nodules

    Multiple tumor nodules

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H., Debra Zynger, M.D., Case #318 and Fulvio Lonardo, M.D.
    Metastatic colon CA to lung 25x

    Metastatic colon CA to lung 25x

    Clear cell renal<br>cell carcinoma<br>metastatic to lung

    Clear cell renal
    cell carcinoma
    metastatic to lung

    Prostatic<br>adenocarcinoma<br>metastatic to lung

    Prostatic
    adenocarcinoma
    metastatic to lung

    Testicular germ<br>cell tumor (teratoma)<br>metastatic to lung

    Testicular germ
    cell tumor (teratoma)
    metastatic to lung

    Jaw: ameloblastoma<br>metastatic to lung

    Jaw: ameloblastoma
    metastatic to lung


    Pancreas: adenocarcinoma Pancreas: adenocarcinoma

    Pancreas: adenocarcinoma

    Cytology images

    Contributed by Roseann Wu, M.D., M.P.H.
    Metastatic renal cell carcinoma to lung

    Metastatic renal cell carcinoma to lung



    Images hosted on other servers:
    Bladder, urothelial carcinoma

    Bladder, urothelial carcinoma


    Micronodular pneumocyte hyperplasia
    Gross images

    Images hosted on other servers:
    Figure A: Macroscopic examination<br>showing white tinged lesions

    Figure A: Macroscopic examination
    showing white tinged lesions

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.
    Micronodular pneumocyte hyperplasia

    Micronodular pneumocyte hyperplasia

    TTF1 stain

    TTF1 stain



    Images hosted on other servers:
    Morphology of pulmonary lesions

    Morphology of pulmonary lesions

    Multifocal micronodular pneumocyte hyperplasia

    Multifocal micronodular pneumocyte hyperplasia


    Minimally invasive
    Radiology images

    Images hosted on other servers:
    Ground glass lesion on CT scan

    Ground glass lesion on CT scan

    Gross images

    Contributed by Sarah Aziz, M.D.
    Lobectomy specimen

    Lobectomy specimen

    Microscopic (histologic) images

    Contributed by Jonathan Keow, M.D., Ph.D.
    Noninvasive and invasive components

    Noninvasive and invasive components

    Noninvasive lepidic adenocarcinoma

    Noninvasive lepidic adenocarcinoma

    Focus of invasive adenocarcinoma

    Focus of invasive adenocarcinoma


    Minute pulmonary meningothelial-like nodules
    Radiology images

    Images hosted on other servers:

    CT scan with
    1 cm nodule

    Positron emission tomography

    Chest film shows bilateral diffuse nodules

    CT scan shows nodules

    Microscopic (histologic) images

    Contributed by Jian-Hua Qiao, M.D.
    Interstitial nests of spindle cells Interstitial nests of spindle cells

    Interstitial nests of spindle cells

    CD56

    CD56

    EMA

    EMA


    PR

    PR

    Vimentin

    Vimentin

    AE1 / AE3

    AE1 / AE3

    CK5 / 6

    CK5 / 6

    Cytology images

    Contributed by Jian-Hua Qiao, M.D.
    Papanicolaou (Pap) stain Papanicolaou (Pap) stain Papanicolaou (Pap) stain

    Papanicolaou (Pap) stain

    p63

    p63

    p40

    p40

    Electron microscopy images

    Images hosted on other servers:

    Interdigitating cells and desmosomes


    Mucoepidermoid carcinoma
    Radiology images

    Images hosted on other servers:
    Heterogeneously enhancing lesion

    Heterogeneously enhancing lesion

    Mass shadow measuring 30 mm

    Mass shadow measuring 30 mm

    Mass in right upper lobe and left hilum

    Mass in right upper lobe and left hilum

    Clinical images

    Images hosted on other servers:
    Well circumscribed endobronchial tumor

    Well circumscribed endobronchial tumor

    Gross images

    Images hosted on other servers:
    Mucoepidermoid carcinoma of airways

    Mucoepidermoid carcinoma of airways

    Tumor in middle lobe bronchus

    Tumor in middle lobe bronchus

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H. and Yale Rosen, M.D.
    Low grade mucoepidermoid carcinoma

    Low grade mucoepidermoid carcinoma

    Low grade MEC mucicarmine stain

    Low grade MEC mucicarmine stain

    High grade mucoepidermoid carcinoma High grade mucoepidermoid carcinoma

    High grade mucoepidermoid carcinoma

    Mucoepidermoid carcinoma, low grade Mucoepidermoid carcinoma, low grade

    Mucoepidermoid carcinoma, low grade


    Stroma infiltrated by inflammatory cells

    Stroma infiltrated by inflammatory cells



    Images hosted on other servers:
    MEC of lung

    MEC of lung

    EGFR seen in squamous and intermediate cells

    EGFR seen in squamous and intermediate cells

    Pulmonary MEC Pulmonary MEC Pulmonary MEC

    Pulmonary MEC

    MEC-like pulmonary carcinoma

    MEC-like pulmonary carcinoma

    Molecular / cytogenetics images

    Images hosted on other servers:
    <i>MAML2</i> rearrangement by FISH

    MAML2 rearrangement by FISH


    Mycoplasma pneumoniae
    Videos


    Gliding phase

    Nocardia
    Gross images

    Images hosted on other servers:
    Abscess

    Abscess

    Microscopic (histologic) images

    Contributed by Yale Rosen, M.D.
    Small abscess

    Small abscess

    Gram stain Gram stain

    Gram stain



    Images hosted on other servers:
    Modified acid fast stain shows weakly acid fast branching, filamentous bacilli

    Modified acid fast stain
    shows weakly acid fast
    branching, filamentous bacilli


    Nodular amyloid (amyloidoma)
    Gross images

    Contributed by Dr. Sajna V.M. Kutty, MVR Cancer Centre and Research Institute, Kozhikode, Kerala, India

    Rib tumor

    Microscopic (histologic) images

    Contributed by Dr. Sajna V.M. Kutty, MVR Cancer Centre and Research Institute, Kozhikode, Kerala, India

    Amyloid deposits

    Apple green birefringence



    Case #197

    Lung nodules - H&E

    Congo red - polarizing microscopy

    Cytology images

    Case #197

    Fine needle aspiration of lung nodule


    Nonspecific interstitial pneumonia
    Diagrams / tables

    Images hosted on other servers:
    Schema of NSIP pattern

    Schema of NSIP pattern

    Radiology images

    Images hosted on other servers:
    NSIP pattern on HRCT

    NSIP pattern on HRCT

    Microscopic (histologic) images
    Scroll to see all images.

    Contributed by Akira Yoshikawa, M.D.
    Low power

    Low power

    Uniform involvement

    Uniform involvement

    Less inflamed

    Less inflamed

    Lymphocytic infiltration and fibrosis

    Lymphocytic infiltration and fibrosis

    Lymphoid follicles with germinal center

    Lymphoid follicles with germinal center

    Lymphoplasmacytic infiltration

    Lymphoplasmacytic infiltration


    Low power

    Low power

    Uniform involvement

    Uniform involvement

    Sparse architectural distortion

    Sparse architectural distortion

    Peribronchiolar metaplasia

    Peribronchiolar metaplasia

    A few honeycomb changes

    A few honeycomb changes

    Dense fibrosis

    Dense fibrosis


    Low power

    Low power

    Uniform involvement

    Uniform involvement

    Lymphocytic infiltration and fibrosis

    Lymphocytic infiltration and fibrosis

    Pleuritis

    Pleuritis

    Organizing pneumonia

    Organizing pneumonia

    Lymphocytic aggregation

    Lymphocytic aggregation


    Airway centered change

    Airway centered change

    Low power

    Low power

    Uniform involvement with lymphoid follicles

    Uniform involvement with lymphoid follicles

    Lymphoid follicles with germinal center

    Lymphoid follicles with germinal center

    Pleuritis with lymphoid follicles

    Pleuritis with lymphoid follicles

    Dense fibrosis are sparsely seen

    Dense fibrosis are sparsely seen



    Images hosted on other servers:
    Diffuse and uniform inflammation Diffuse and uniform inflammation Diffuse and uniform inflammation Diffuse and uniform inflammation

    Diffuse and uniform inflammation

    Cellular NSIP

    Cellular NSIP


    Fibrotic NSIP Fibrotic NSIP

    Fibrotic NSIP

    Pleuritis

    Pleuritis

    Organizing pneumonia in NSIP

    Organizing pneumonia in NSIP

    Series of slides of fibrotic NSIP

    Series of slides of fibrotic NSIP


    NUT carcinoma
    Microscopic (histologic) images

    Contributed by Kyriakos Chatzopoulos, M.D., Ph.D. and Kassiani Boulogeorgou, M.D.

    Cytomorphology of NUT carcinoma

    NUT abrupt keratinization

    NUT immunostain


    Organizing pneumonia
    Diagrams / tables

    Images hosted on other servers:
    Typical organizing pneumonia

    Classification of interstitial lung diseases

    Typical organizing pneumonia

    Imaging patterns of cryptogenic organizing pneumonia

    Radiology images

    Images hosted on other servers:
    Typical organizing pneumonia Typical organizing pneumonia

    Typical organizing pneumonia

    Typical organizing pneumonia Typical organizing pneumonia Typical organizing pneumonia

    Typical organizing pneumonia


    Chest radiograph Chest radiograph

    Chest radiograph

    Focal organizing pneumonia Focal organizing pneumonia

    Focal organizing pneumonia

    Infiltrative organizing pneumonia

    Infiltrative organizing pneumonia

    Gross images

    Contributed by Yale Rosen, M.D.
    Pale area of nodular consolidation

    Pale area of nodular consolidation

    Mass-like lesions

    Mass-like lesions



    Images hosted on other servers:
    Typical organizing pneumonia

    Cryptogenic organizing pneumonia

    Microscopic (histologic) images

    Contributed by Akira Yoshikawa, M.D. and Yale Rosen, M.D.
    Patchy involvement

    Patchy involvement

    Fibroblast plug Fibroblast plug

    Fibroblast plug

    Fibroblast plug

    Fibroblast plug

    Fibroblast plug Fibroblast plug

    Fibroblast plug


    Fibroblast plug Fibroblast plug

    Fibroblast plug

    Fibroblast plug Fibroblast plug

    Fibroblast plug

    Mononuclear cells infiltrate

    Mononuclear cell infiltrate

    Foamy macrophages

    Foamy macrophages


    Cicatricial variant Cicatricial variant

    Cicatricial variant

    Cicatricial variant

    Cicatricial variant

    Videos

    Cryptogenic organizing pneumonia

    Focal organizing pneumonia

    Fibrosing organizing pneumonia


    Paraganglioma
    Radiology images

    Images hosted on other servers:
    Pulmonary nodule

    Pulmonary nodule

    Gross images

    Images hosted on other servers:
    Bulging mass

    Bulging mass

    Microscopic (histologic) images

    Images hosted on other servers:
    Histology of nodule

    Histology of nodule

    Lung tumor cells

    Lung tumor cells


    PEComa (clear cell tumor)
    Radiology images

    Images hosted on other servers:
    CT of clear cell tumor of lung

    CT of clear cell tumor of lung


    Gross images

    Images hosted on other servers:
    Well circumscribed tumors Well circumscribed tumors

    Well circumscribed tumors

    4 cm, gray-white, circumscribed tumor<br>confined to the lower lobe under the pleura

    4 cm, gray-white, circumscribed tumor
    confined to the lower lobe under the pleura

    Microscopic (histologic) images

    Images hosted on other servers:
    (A) Core needle biopsy shows neoplastic cells in nested and insular pattern surrounding numerous thinned wall sinusoid-like vessels<br>(B) intranuclear cytoplasmic invaginations<br>(C) HMB45+ staining

    (A) Core needle biopsy shows neoplastic cells in nested and insular pattern surrounding numerous thinned wall sinusoid-like vessels
    (B) intranuclear cytoplasmic invaginations
    (C) HMB45+ staining


    Tumor with malignant histology Tumor with malignant histology Tumor with malignant histology Tumor with malignant histology Tumor with malignant histology

    Tumor with malignant histology

    Various images

    Various images

    Cytology images

    Images hosted on other servers:
    Benign sclerosing perivascular<br>epithelioid cell tumor (PEComa)

    Benign sclerosing perivascular
    epithelioid cell tumor (PEComa)

    (A) Large, irregular, cohesive clusters of columnar and spindle-shaped cells in background of single naked nuclei (Pap)
    (B) several large clusters with open cribriform-like spaces (Pap)
    (C) spindle-shaped and polygonal cells with round to oval nuclei and vacuolated ill-defined cytoplasm (Pap)
    (D) cell block shows neoplastic cells arranged in a nested and insular pattern surrounding sinusoid-like vessels; inset shows sinusoid-like vessel amidst tumor


    Pleomorphic adenoma
    Radiology images

    Images hosted on other servers:
    Enhanced and nonenhanced CT scan

    Enhanced and nonenhanced CT scan

    Gross images

    Images hosted on other servers:
    Cut surface shows a well defined<br>mass, whitish to yellowish,<br>partly myxoid, solid and cystic

    Cut surface shows a well defined
    mass, whitish to yellowish,
    partly myxoid, solid and cystic

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.
    Various images Various images Various images Various images Various images

    Various images



    Images hosted on other servers:
    Metastasizing tumor with benign features

    Metastasizing tumor with benign features


    Pleomorphic carcinoma
    Radiology images

    Images hosted on other servers:
    CT of lung nodule

    CT of lung nodule

    Clinical images

    Images hosted on other servers:
    Endobronchial tumor

    Endobronchial tumor

    Gross images

    Images hosted on other servers:
    8 x 7 cm tumor

    8 x 7 cm tumor

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.
    Giant cell CA lung HE

    Giant cell CA lung HE

    Giant cell CA LUNG HE

    Giant cell CA lung HE



    Images hosted on other servers:
    8 x 7 cm tumor

    8 x 7 cm tumor

    Diffuse proliferation of atypical, giant and bizarre cells

    Diffuse proliferation of atypical, giant and bizarre cells

    Cytology images

    Contributed by Roseann Wu, M.D., M.P.H.
    Giant cell CA ThinPrep

    Giant cell CA ThinPrep


    Pleuropulmonary blastoma
    Gross images

    Contributed by Erdener Özer, M.D., Ph.D. and Case #166
    Type III PPB characterized by well circumscribed whitish tan solid tumor Type III PPB

    Type III PPB



    Images hosted on other servers:
    Type I PPB has<br>multiloculated cyst<br>filled with scanty<br>clear serous fluid

    Type I PPB has
    multiloculated cyst
    filled with scanty
    clear serous fluid

    Microscopic (histologic) images

    Contributed by Erdener Özer, M.D., Ph.D., Dr. Roopa Arora and Case #166
    Types I and III PPB Types I and III PPB Types I and III PPB

    Types I and III PPB

    Pleuropulmonary blastoma Pleuropulmonary blastoma Pleuropulmonary blastoma

    Pleuropulmonary blastoma


    Pleuropulmonary blastoma

    Pleuropulmonary blastoma

    SMA

    SMA

    Type III PPB Type III PPB Type III PPB

    Type III PPB


    Type III PPB Type III PPB Type III PPB Type III PPB Type III PPB

    Type III PPB


    Plexiform arteriopathy
    Microscopic (histologic) images

    Images hosted on other servers:
    Plexiform lesion

    Plexiform lesion


    Pneumocystis
    Diagrams / tables

    Images hosted on other servers:
    Life cycle

    Life cycle

    Radiology images

    Images hosted on other servers:
    Chest imaging

    Chest imaging

    Bilateral well defined cystic spaces in lung

    Bilateral well defined cystic spaces in lung

    Gross images

    Images hosted on other servers:
    Confluent consolidation and fine porosity

    Confluent consolidation and fine porosity

    Microscopic (histologic) images

    Contributed by Aliya N. Husain, M.D.
    Intra-alveolar Pneumocystis jirovecii organisms

    Intra-alveolar Pneumocystis jirovecii organisms

    Granulomatous inflammation

    Granulomatous inflammation

    Foamy amorphous material

    Foamy amorphous material

    Intra-alveolar pneumocystis organisms

    Intra-alveolar Pneumocystis organisms

    Cytology images

    Images hosted on other servers:
    Bronchoalveolar lavage washings

    Bronchoalveolar lavage washings


    Preinvasive-general
    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.
    Moderate to severe dysplasia

    Moderate to severe dysplasia



    Images hosted on other servers:
    Missing Image

    Various images

    Missing Image

    Normal bronchial mucosa


    Primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion
    Radiology images

    Contributed by Hongxing (Simon) Gui, M.D., Ph.D.
    Endobronchial mass

    Endobronchial mass

    Microscopic (histologic) images

    Contributed by Hongxing (Simon) Gui, M.D., Ph.D.
    Nodular mass

    Nodular mass

    Reticular pattern

    Reticular pattern

    Multinodular growth

    Multinodular growth

    Spindle cells

    Spindle cells


    Hybrid patterns

    Hybrid patterns

    Angiomatoid fibrous histiocytoma area

    Angiomatoid fibrous histiocytoma area

    Spindle cells in lacy pattern

    Spindle cells in lacy pattern


    Pseudomonas
    Gross images

    Contributed by Yale Rosen, M.D.
    Pseudomonas pneumonia Pseudomonas pneumonia

    Pseudomonas pneumonia


    Pulmonary artery intimal sarcoma
    Diagrams / tables

    Images hosted on other servers:

    Most common histologic patterns

    Radiology images

    Contributed by Andre L. Moreira, M.D., Ph.D.
    Contrast CT: filling defect

    Contrast CT: filling defect



    Images hosted on other servers:

    Transesophageal echo (TEE): large mobile masses

    Echo: masses below pulmonary valve

    Contrast CT: filling defect

    CT showing filling defect


    CT: filling defect

    Intense avidity on PET

    CT: multiple lung nodules

    Clinical images

    Images hosted on other servers:

    Glossy white tumor, pulmonary trunk

    Intraoperative images of tumor

    Gross images

    Contributed by Andre L. Moreira, M.D., Ph.D.
    Pulmonary artery with tumor

    Pulmonary artery with tumor



    Images hosted on other servers:

    Mass mimicking saddle pulmonary embolism

    Yellow solid tumor mass

    Occlusion, main pulmonary artery

    Filling arterial branches (arrows)

    Distending arterial branches (arrows)

    Microscopic (histologic) images

    Contributed by Andre L. Moreira, M.D., Ph.D. and Borislav A. Alexiev, M.D. (Case #535)
    Atypical spindle cell neoplasm

    Atypical spindle cell neoplasm

    Atypical spindle cells arranged in fascicles

    Atypical spindle cells arranged in fascicles

    Atypical spindle cells

    Atypical spindle cells

    Atypical spindle cells, fascicles

    Atypical spindle cells, fascicles

    High grade nuclei, mitoses <p>High grade nuclei, mitoses</div>

    High grade nuclei, mitoses


    Polypoid tumor with fibrin

    Polypoid tumor with fibrin

    Tumor in fibrin

    Tumor in fibrin

    Tumor in artery wall

    Tumor in artery wall

    Atypical mitoses

    Atypical mitoses

    Myxoid and hypocellular areas

    Myxoid and hypocellular areas

    Nuclear pleomorphism

    Nuclear pleomorphism


    Tumor necrosis

    Tumor necrosis

    Vascularity within tumor Vascularity within tumor

    Vascularity within tumor

    Smooth muscle actin IHC

    Smooth muscle actin IHC

    MDM2 IHC

    MDM2 IHC

    Mimicker of blood clot

    Mimicker of blood clot


    Mimicker of organized clot Mimicker of organized clot

    Mimicker of organized clot

    Mimicker of IMT

    Mimicker of IMT


    Cytology images

    Images hosted on other servers:

    Clusters of spindled cells in PAIS

    Pleomorphic cells with vacuolated cytoplasm

    Pleomorphic spindle cells in PAIS

    Molecular / cytogenetics images

    Contributed by Borislav A. Alexiev, M.D. (Case #535)
    <i>MDM2</i> gene in red

    MDM2 gene in red



    Images hosted on other servers:
    FISH study with <i>MDM2</i>

    FISH study with MDM2

    Cardiac: <i>MDM4</i> and <i>CDK6</i>

    Cardiac: MDM4 and CDK6

    <i>MDM2</i> FISH

    MDM2 FISH


    Pulmonary blastoma
    Radiology images

    Images hosted on other servers:
    Missing Image

    Mass near hilum

    Missing Image

    Compression of vena cava

    Missing Image

    Uptake within mass

    Missing Image

    Right mass

    Gross images

    Images hosted on other servers:
    Missing Image

    Solid mass

    Missing Image

    Hemorrhagic mass

    Microscopic (histologic) images

    Contributed by Hongxing Gui, M.D., Ph.D. and University of Michigan Virtual Slide Box
    Epithelial and mesenchymal components Epithelial and mesenchymal components

    Epithelial and mesenchymal components

    Glandular epithelium and blastematous stroma Glandular epithelium and blastematous stroma

    Glandular epithelium and blastematous stroma


    TTF1

    TTF1

    Vimentin

    Vimentin

    Beta catenin

    Beta catenin


    Pulmonary capillary hemangiomatosis
    Clinical images

    Images hosted on other servers:
    Category 1 pulmonary hypertension<br>diagnosed postmortem as secondary to<br>pulmonary capillary hemangiomatosis (PCH)

    Category 1 pulmonary hypertension
    diagnosed postmortem as secondary to
    pulmonary capillary hemangiomatosis (PCH)

    Category 1 pulmonary hypertension<br>due to a second case of pulmonary<br>capillary hemangiomatosis

    Category 1 pulmonary hypertension
    due to a second case of pulmonary
    capillary hemangiomatosis

    Gross images

    Images hosted on other servers:
    Left lung with pulmonary parenchyma

    Left lung with pulmonary parenchyma

    Microscopic (histologic) images

    Contributed by Yale Rosen, M.D.
    Pulmonary veno-occlusive disease - Capillary dilatation

    Pulmonary veno-
    occlusive disease -
    Capillary dilatation

    Pulmonary capillary hemangiomatosis Pulmonary capillary hemangiomatosis

    Pulmonary capillary hemangiomatosis



    Images hosted on other servers:
    (A)small veins demonstrate marked myointimal thickening; adjacent alveolar septa are<br>thickened by endothelial cell proliferation of pulmonary capillary hemangiomatosis;<br>(B) CD31 highlights endothelial cell proliferation

    (A)small veins demonstrate marked myointimal thickening; adjacent alveolar septa are
    thickened by endothelial cell proliferation of pulmonary capillary hemangiomatosis;
    (B) CD31 highlights endothelial cell proliferation


    Pulmonary capillary hemangiomatosis Pulmonary capillary hemangiomatosis Pulmonary capillary hemangiomatosis

    Pulmonary capillary hemangiomatosis


    Pulmonary hamartoma
    Radiology images

    Contributed by Jeffrey P. Kanne, M.D.
    Hamartoma with calcifications

    With calcifications

    Hamartoma CT scan

    CT scan

    Clinical images

    Images hosted on other servers:

    Bronchoscopy

    Large endobronchial hamartoma

    Large endobronchial mass

    Gross images

    Contributed by @Andrew_Fltv on Twitter
    Pulmonary hamartoma Pulmonary hamartoma Pulmonary hamartoma

    Pulmonary hamartoma



    Images hosted on other servers:

    Pneumonectomy specimen

    Various images

    Firm and discrete lesions

    Various images

    Resected endobronchial tumor

    Microscopic (histologic) images

    Contributed by Hui-Hua Li, M.D., Ph.D. and Jefree J. Schulte, M.D.
    Hamartoma with cartilage

    With cartilage

    Fat rich hamartoma

    Fat rich

    Hamartoma, typical features

    Typical features

    Hamartoma, fat / myxoid stroma

    Fat / myxoid stroma


    Hamartoma, bland spindle cells

    Bland spindle cells

    Pulmonary hamartoma core biopsy

    Core biopsy

    Pulmonary hamartoma biopsy, cartilage

    Biopsy, cartilage

    Pulmonary hamartoma biopsy, epithelium

    Biopsy, epithelium



    Contributed by @Andrew_Fltv on Twitter
    Pulmonary hamartoma Pulmonary hamartoma

    Pulmonary hamartoma

    Cytology images

    Images hosted on other servers:

    FNA smears


    Pulmonary hypertension
    Gross images

    Images hosted on other servers:
    Atherosclerosis

    Atherosclerosis


    Pulmonary placental transmogrification
    Gross images

    Images hosted on other servers:

    Massively dilated bullae

    Fatty infiltration

    Fatty infiltration

    Microscopic (histologic) images

    Contributed by Jian-Hua Qiao, M.D.
    Foci of subpleural bullous emphysema Foci of subpleural bullous emphysema

    Foci of subpleural bullous emphysema

    Clusters of mature placental chorionic villi-like structures Clusters of mature placental chorionic villi-like structures Clusters of mature placental chorionic villi-like structures Clusters of mature placental chorionic villi-like structures

    Clusters of mature placental chorionic villi-like structures



    Images hosted on other servers:

    Fatty infiltration


    Pulmonary zoonoses
    Microscopic (histologic) images

    Images hosted on other servers:
    Various images Various images

    Rhodococcus

    Electron microscopy images

    Images hosted on other servers:
    Transmission electron<br>micrograph of<br>Sin Nombre hantavirus

    Transmission electron
    micrograph of
    Sin Nombre hantavirus


    Respiratory bronchiolitis
    Radiology images

    Images hosted on other servers:

    RB-ILD chest radiograph and CT scan

    Microscopic (histologic) images

    Contributed by Kristine Konopka, M.D.

    Macrophage accumulation

    Smoker's macrophages

    Iron stain


    RSV
    Microscopic (histologic) images

    Images hosted on other servers:
    Giant cells

    Giant cells


    Sarcoidosis
    Radiology images

    Images hosted on other servers:

    Some HRCT patterns

    Gross images

    Contributed by @AKhannaMBBS on Twitter
    Sarcoidosis Sarcoidosis

    Sarcoidosis



    Images hosted on other servers:

    Hilar lymphadenopathy in sarcoidosis

    Microscopic (histologic) images

    Contributed by Aliya N. Husain, M.D. and @AKhannaMBBS on Twitter
    Multinulceated giant cells and fibrosis Multinulceated giant cells and fibrosis

    Multinulceated giant cells and fibrosis

    Granuloma with asteroid body

    Granuloma with asteroid body

    Mediastinal node with granulomas and fibrosis

    Mediastinal node with granulomas and fibrosis


    Granulomas of bronchovascular bundle and pleura

    Granulomas of bronchovascular bundle and pleura

    Granulomas with fibrosis

    Granulomas with fibrosis

    Sarcoidosis Sarcoidosis

    Sarcoidosis


    Sclerosing pneumocytoma
    Radiology images

    Images hosted on other servers:

    Well defined nodular lesion in peripheral lung

    Gross images

    Images hosted on other servers:

    Well demarcated hemorrhagic peripheral lung lesion

    Microscopic (histologic) images

    Contributed by Matthew J. Cecchini, M.D., Ph.D. and Pooja Navale, M.D.
    Core needle biopsy with various growth patterns

    Core needle biopsy with various growth patterns

    Core needle biopsy with 2 cell population

    Core needle biopsy with 2 cell population

    Well demarcated lesion

    Well demarcated lesion

    Solid growth architecture

    Solid growth architecture

    Papillary architecture

    Papillary architecture


    Hemorrhagic areas

    Hemorrhagic areas

    Prominent foamy macrophages

    Prominent foamy macrophages

    Whole mount view

    Whole mount view

    Solid tumor

    Solid tumor

    Surface cells and round cells

    Surface cells and round cells


    TTF1 highlights both cell populations

    TTF1 highlights both cell populations

    Pancytokeratin highlights the surface cells

    Pancytokeratin highlights the surface cells

    TTF1

    TTF1

    EMA

    EMA

    CAM 5.2

    CAM 5.2

    Videos

    Sclerosing pneumocytoma in small biopsy

    Sclerosing pneumocytoma in resection


    Sequestrations
    Diagrams / tables

    Images hosted on other servers:

    ILS as seen at surgery

    Radiology images

    Images hosted on other servers:

    Xray

    Ultrasound

    CT scan

    Gross images

    Contributed by Jennifer Pogoriler, M.D., Ph.D.
    ILS with systemic vessel

    ILS with systemic vessel

    Cut surface ILS with systemic vessel

    Cut surface ILS with systemic vessel

    ELS and feeding vessel

    ELS and feeding vessel

    Cut surface of ELS

    Cut surface of ELS

    ELS with prominent lymphatics

    ELS with prominent lymphatics

    ELS with cystic changes

    ELS with cystic changes

    Microscopic (histologic) images

    Contributed by Jennifer Pogoriler, M.D., Ph.D.
    ILS aberrant hilum

    ILS aberrant hilum

    Normal lung adjacent to ILS

    Normal lung adjacent to ILS

    ILS with parenchymal maldevelopment

    ILS with parenchymal maldevelopment

    Cystic changes in ELS

    Cystic changes in ELS


    ELS with prominent lymphangiectasia

    ELS with prominent lymphangiectasia

    Skeletal muscle in septae

    Skeletal muscle in septa

    High power skeletal muscle

    High power skeletal muscle


    Silicosis
    Microscopic (histologic) images

    Images hosted on other servers:
    Silicotic nodule

    Silicotic nodule

    Silica crystals (polarized light)

    Silica crystals (polarized light)


    Small cell carcinoma
    Radiology images

    Images hosted on other servers:

    Right hilar mass

    Left hilar mass

    Gross images

    Contributed by Carolyn Glass, M.D.

    Central tumor with bronchial spread



    Images hosted on other servers:

    Hilar mass

    Central tumor

    Spreading along bronchi

    Microscopic (histologic) images

    Contributed by Carolyn Glass, M.D.

    Sheets of tumor cells

    Crushed blue cells

    Cellular morphology

    CK7

    TTF1

    CD56


    Squamous / glandular / mixed papilloma
    Radiology images

    Images hosted on other servers:
    Pedunculated mass

    Pedunculated mass

    Microscopic (histologic) images

    Contributed by Roseann Wu, M.D., M.P.H.



    Images hosted on other servers:
    Various images

    Various images

    Solid mass

    Solid mass

    Schneiderian papilloma

    Schneiderian papilloma

    Bronchiak papilloma

    Bronchial papilloma

    Cytology images

    Images hosted on other servers:
    Cytomorphology

    Cytomorphology


    Squamous cell carcinoma
    Radiology images

    Images hosted on other servers:
    Central mass with cavitation

    Central mass with cavitation

    Peripheral mass with collapse

    Peripheral mass with collapse

    Gross images

    Contributed by @yro854 on Twitter
    Squamous cell carcinoma

    Squamous cell carcinoma



    Images hosted on other servers:
    Central cavitation

    Central cavitation

    Tumor obstructing bronchus

    Tumor obstructing bronchus

    Tumor extending to pleura

    Tumor extending to pleura

    Microscopic (histologic) images

    Contributed by Alex McGeough, M.D. and Andrey Bychkov, M.D., Ph.D.
    Tumor budding

    Tumor budding

    Well differentiated squamous cell carcinoma

    Well differentiated

    Intercellular bridging

    Intercellular bridging

    Intercellular bridging

    Intratumoral necrosis

    Poorly differentiated squamous cell carcinoma

    Poorly differentiated

    Moderately differentiated squamous cell carcinoma

    Moderately differentiated


    Prominent cytologic atypia

    Prominent cytologic atypia

    Keratin pearls

    Keratin pearls

    Basaloid type

    Basaloid type

    Palisading nuclei in basaloid type

    Palisading nuclei in basaloid type

    p40 positive in basaloid type

    p40 positive in basaloid type


    Bronchial biopsy

    Bronchial biopsy

    Nonkeratinizing, moderately differentiated squamous cell carcinoma

    Nonkeratinizing

    p40 staining

    p40 staining

    CK 5/6

    CK 5/6

    SCC cocktail

    SCC cocktail

    Cytology images

    Images hosted on other servers:
    Keratinization and tadpole cell

    Keratinization and tadpole cell


    Squamous cell carcinoma in situ
    Clinical images

    Images hosted on other servers:
    Right main bronchus under a) white light and b) autofluorescence

    Right main bronchus
    under a) white
    light and b) auto-
    fluorescence

    Microscopic (histologic) images

    Contributed by Gheorghe-Emilian Olteanu, M.D., Ph.D., Ana Mataić, M.D. and Luka Brčić, M.D., Ph.D.
    Normal respiratory epithelium

    Normal respiratory epithelium

    Normal respiratory epithelium and SCIS

    Normal respiratory epithelium and SCIS

    Upper layer spot necrosis

    Upper layer spot necrosis

    Flattening of the upper layer

    Flattening of the upper layer

    Polypoid growth pattern

    Polypoid growth pattern

    Pleomorphic cells

    Pleomorphic cells

    Videos

    SCIS histopathology - lung, bronchus


    Staging
    Diagrams / tables

    Images hosted on other servers:
    Missing Image

    Staging chart

    Videos

    Staging animation

    Updates on TNM staging (2017)

    8th TNM classification (2018)


    Strongyloides
    Diagrams / tables

    Images hosted on other servers:
    Life cycle

    Life cycle

    Microscopic (histologic) images

    Case #133
    Small bowel infection

    Small bowel infection



    Images hosted on other servers:
    Small bowel infection Small bowel infection

    Small bowel infection

    Cytology images

    Contributed by anonymous
    Bronchial wash

    Bronchial wash

    Pap stain

    Pap stain

    Diff-Quik

    Diff-Quik



    Images hosted on other servers:
    Bronchial wash

    Bronchial wash

    BAL fluid

    BAL fluid


    Transplantation / rejection
    Radiology images

    Images hosted on other servers:
    Hyperacute lung transplant rejection

    Hyperacute lung transplant rejection

    Acute rejection (A1)

    Acute rejection (A1)

    Restrictive allograft syndrome

    Restrictive allograft syndrome

    Gross images

    Contributed by M. Ángeles Montero-Fernández, M.D., Ph.D.
    Explant lung with diffuse alveolar damage

    Explant lung with diffuse alveolar damage

    Idiopathic pleuroparenchymal fibroelastosis

    Idiopathic pleuroparenchymal fibroelastosis

    Chronic lung allograft dysfunction

    Chronic lung allograft dysfunction

    Microscopic (histologic) images

    Contributed by M. Ángeles Montero-Fernández, M.D., Ph.D.
    Alveolar septal capillaritis

    Alveolar septal capillaritis

    Minimal acute cellular rejection (A1)

    Minimal acute cellular rejection (A1)

    Moderate acute cellular rejection (A3)

    Moderate acute cellular rejection (A3)

    Severe acute cellular rejection (A4)

    Severe acute cellular rejection (A4)


    Lymphocytic bronchiolitis (B2R)

    Lymphocytic bronchiolitis (B2R)

    Obliterative bronchiolitis

    Obliterative bronchiolitis

    Acute fibrinous and organizing pneumonia

    Acute fibrinous and organizing pneumonia

    Acute lung injury

    Acute lung injury

    C4d

    C4d

    Videos

    Indications, patient selection and outcomes


    Tuberculosis
    Diagrams / tables

    Images hosted on other servers:

    Mycobacterium tuberculosis infection

    Radiology images

    Images hosted on other servers:

    Chest Xray and high resolution CT of active tuberculosis

    Gross images

    Contributed by Sajna V.M. Kutty, M.D.
    65 year old male chronic smoker with 3 cm lung mass

    65 year old male chronic smoker with 3 cm lung mass



    Images hosted on other servers:
    Lung with cavity

    Lung with cavity and caseous necrosis

    Histomorphological patterns

    Histomorphologic
    patterns of
    postprimary
    tuberculosis

    Microscopic (histologic) images

    Contributed by Hui-Hua Li, M.D., Ph.D., Jefree J. Schulte, M.D. and Aliya N. Husain, M.D.
    Necrotizing granuloma core biopsy

    Necrotizing granuloma core biopsy

    Giant cells

    Giant cells

    Large necrotizing granuloma

    Large necrotizing granuloma

    Necrotizing granuloma

    Necrotizing granuloma

    Positive AFB stain

    Positive AFB stain



    Contributed by @AnaPath10 on Twitter
    Tuberculosis Tuberculosis Tuberculosis

    Tuberculosis

    Cytology images

    Images hosted on other servers:

    Lymph node tuberculosis

    Lymph node tuberculosis

    Videos

    Case of pulmonary tuberculosis with granulomas

    Histopathology of pulmonary tuberculosis


    Typical carcinoid tumor / neuroendocrine tumor, grade 1
    Radiology images

    Contributed by Philippe Joubert, M.D., Ph.D. and Case #266

    CT scan: endoluminal tumor

    Central carcinoid tumor

    Clinical images

    Contributed by Simon Martel, M.D.

    Bronchoscopy: endoluminal tumor

    Gross images

    Contributed by Sylvain Trahan, M.D. and Yale Rosen, M.D.

    Endoluminal tumor

    Peripheral tumor

    Large polypoid tumor

    Microscopic (histologic) images

    Contributed by Philippe Joubert, M.D., Ph.D., Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.

    Endobronchial carcinoid

    Rosettes

    Trabecular and solid

    Solid and zellballen

    Trabecular

    Pseudorosettes


    Pseudogland formation

    Salt and pepper chromatin

    Spindle cell features

    Focal cytologic atypia

    Clear cells

    Stroma ossification


    High vascularization

    Lymph node metastasis

    Lymphovascular invasion

    Submucosal nodule

    Uniform small cells


    Uniform small cells

    AE1 / AE3

    CD56

    TTF1

    Ki67

    Typical carcinoid immunoprofile

    Cytology images

    Contributed by Philippe Joubert, M.D., Ph.D.

    Loosely cohesive groups

    Cells branching around a capillary

    Rosette-like structures

    Chromatin detail

    Cell block

    Videos

    Typical carcinoid tumor


    UIP / IPF
    Diagrams / tables

    Images hosted on other servers:
    Schema of UIP pattern

    Schema of UIP pattern

    IPF diagnosis by lung biopsy and HRCT

    IPF diagnosis by lung biopsy and HRCT

    Radiology images

    Images hosted on other servers:
    Usual interstitial pneumonia (UIP) pattern Usual interstitial pneumonia (UIP) pattern Usual interstitial pneumonia (UIP) pattern

    Usual interstitial pneumonia (UIP) pattern

    UIP and possible UIP pattern

    UIP and possible UIP pattern

    Gross images

    Images hosted on other servers:
    Honeycomb lung

    Honeycomb lung

    Cobblestone appearance of the pleura

    Cobblestone appearance of the pleura

    Microscopic (histologic) images

    Contributed by Akira Yoshikawa, M.D. and Yale Rosen, M.D.
    Spatial heterogeneity Spatial heterogeneity

    Spatial heterogeneity

    Spatial heterogeneity

    Spatial heterogeneity

    Subpleural fibrosis

    Subpleural fibrosis

    Subpleural and paraseptal fibrosis

    Subpleural and paraseptal fibrosis

    Paraseptal fibrosis

    Paraseptal fibrosis


    Dense fibrosis

    Dense fibrosis

    Dense fibrosis with architectural destruction

    Dense fibrosis with architectural destruction

    Honeycomb change Honeycomb change

    Honeycomb change

    Honeycomb change Honeycomb change

    Honeycomb change


    Fibroblastic foci

    Honeycomb change

    Fibroblast focus Fibroblast focus

    Fibroblast focus

    Fibroblast focus

    Fibroblast focus

    Fibroblast focus Fibroblast focus

    Fibroblast focus


    Peribronchiolar metaplasia Peribronchiolar metaplasia

    Peribronchiolar metaplasia

    PAP-like change

    PAP-like change

    Respiratory bronchiolitis

    Respiratory bronchiolitis

    Squamous metaplasia

    Squamous metaplasia

    Fat metaplasia

    Fat metaplasia


    Bone metaplasia

    Bone metaplasia

    Elastosis

    Elastosis

    Videos

    Usual interstitial pneumonia

    Usual interstitial pneumonia

    Usual interstitial pneumonia


    Vaping associated acute lung injury
    Radiology images

    Contributed by Matthew J. Cecchini, M.D., Ph.D. and Brandon T. Larsen, M.D., Ph.D.

    Ground glass & consolidation

    Ground glass

    Microscopic (histologic) images

    Contributed by Matthew J. Cecchini, M.D., Ph.D. and Brandon T. Larsen, M.D., Ph.D.

    Diffuse alveolar damage

    Acute lung injury with organizing pneumonia

    Acute fibrinous pneumonitis

    Bronchiolitis

    Foamy change


    Veliparib
    Diagrams / tables

    Images hosted on other servers:

    Mechanism of PARP1 inhibitor in cancer cells

    Back to top
    Recent Lung Pathology books

    Cagle: 2015

    Churg: 2019

    Duarte Achcar: 2016

    Fraig: 2015

    Husain: 2021

    IAC-IARC-WHO: 2023

    IARC: 2015

    IARC: 2021

    Jiang: 2023

    Katzenstein: 2016

    Mukhopadhyay: 2016

    Mukhopadhyay: 2023

    Papotti: 2015

    Popper: 2016

    Smith: 2023

    Suster : 2020

    Suster: 2022

    VandenBussche: 2017

    VandenBussche: 2019

    Zhang: 2018



    Find related Pathology books: cardiovascular, cytopathology, GI, lung, mediastinum/serosa, pediatric
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