Images hosted on other servers:
Mass in testicular hilum
Solid mass with cystic areas
Contributed by Rafael E. Jimenez, M.D.
Areas of central necrosis
Complex architecture
Transition of epithelium
Complex tubuloglandular pattern
Cribriform pattern
High grade cytomorphology
Increased mitotic activity
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Adenocarcinoma of rete testis
Images hosted on other servers:
Coronal MR
Ultrasound
Contributed by Debra L. Zynger, M.D.
Paratesticular tumor
Images hosted on other servers:
Well circumscribed tumor
Contributed by Sarah Findeis, M.D., Stephanie J. Conrad, M.D., Ming Zhou, M.D.,
the Genitourinary Pathology Society (GUPS) and @katcollmd on Twitter
Interface with testis
Cords and trabeculae pattern
Eosinophilic cells
Calretinin
CK AE1/3
Circumscribed tumor
Dilated cystic spaces
Vacuolated and attenuated epithelium
Bland nuclei
Calretinin
Adenomatoid tumor
Adenomatoid tumor
Adenomatoid tumor
Adenomatoid tumor
Images hosted on other servers:
Moderate cellularity
Monolayered sheets of cells
Contributed by Yuto Yamazaki, M.D., Ph.D., Hironobu Sasano, M.D., Ph.D., Debra L. Zynger, M.D. and Sean R. Williamson, M.D.
Spermatic cord adrenal rest and SF1
Spermatic cord adrenal rests
Paratesticular adrenal cortical rest
Images hosted on other servers:
Hypoechoic lesion
Hypoechoic lesion /
increased vascularity
Increased vascularity
Contributed by Kristine M. Cornejo, M.D.
Tan-yellow solid mass
Lobulated tan-yellow mass
Contributed by Kristine M. Cornejo, M.D.
Nodular appearance
Nuclear grooves
Diffuse pattern
Spindled pattern
Corded pattern
Gyriform / watered silk pattern
Microfollicular pattern (Call-Exner bodies)
Insular pattern
Palisading pattern
Pseudopapillary pattern
Herringbone / fascicular pattern
Luteinized cells
Inhibin A stain
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Scrotum
Transverse section
Right testis
Vertical section
Transverse section
Section of genital cord
Spermatic cord
Subcutaneous inguinal ring
Cremaster
Spermatic veins
Section of epididymis of guinea pig
Fundus of bladder
Contributed by Asmaa Gaber Abdou, M.D. and @Andrew_Fltv on Twitter
Testis histology
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Normal testis
Efferent ducts
Leydig cells
Seminiferous tubules
Various images of epididymis
Various images of spermatic cord
Contributed by @Andrew_Fltv on Twitter
Testicular atrophy
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Comparison to normal testis
Contributed by Patricija Zot, M.D., Rafael E. Jimenez, M.D., @ThatGlassTho on Twitter and @Andrew_Fltv on Twitter
Seminiferous tubules replaced by collagen deposition
Retained germ cells
Atrophy
Testicular atrophy
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CT with testicular mass
Testis ultrasound with calcification
Chest Xray with nodules
Chest Xray in choriocarcinoma syndrome
Chest CT with cannonball metastasis
MRI of brain
Abdominal CT with retroperitoneal mass
Abdomen CT with liver metastasis
Contributed by Debra L. Zynger, M.D. and Andres Matoso, M.D.
Mixed GCT with predominate choriocarcinoma
Mixed GCT with minor component of choriocarcinoma
Large hemorrhagic tumor
Contributed by Debra L. Zynger, M.D.
2 cell types
Hemorrhage
Syncytiotrophoblasts
Syncytiotrophoblast rim
Mononucleated trophoblasts
Choriocarcinoma with IHC
Beta hCG
Inhibin
CK7
GATA3
OCT 3/4
Images hosted on other servers:
Intra-abdominal mass
Abdominal testis
Mass with right gonadal vein
Scrotum with cryptorchidism
Abdominal wall ectopic testis
Contributed by Debra L. Zynger, M.D.
Cryptorchid testicle
Contributed by Debra L. Zynger, M.D.
Sertoli cell only tubules
Absent spermatogenesis
Peritubular fibrosis
Sertoli cell nodule
Retained Leydig cells
Granular cell change within Sertoli cells
Microliths
Contributed by Vikas Mehta, M.D.
Cyst, fibrinoid material
Intermediate type trophoblasts
Intermediate trophoblasts, smudged chromatin
Solid nest, fibrinoid material
βhCG positivity
Images hosted on other servers:
Cyst of testis (focal dilatation of seminiferous tubule)
Cystic dilatation (tubular ectasia) of rete testis
Epididymis cyst
Cystic dilatation (tubular ectasia) of epididymis
Mesothelial cyst in tunica albuginea
Hydrocele
Chronic hydrocele with multiloculated appearance
Spermatic cord cyst
AFIP images
Cyst of tunica albuginea
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Encysted hydrocele
Multiple paratesticular, unilocular, thin walled cysts
Contributed by Stephanie Siegmund, M.D., Ph.D. and AFIP
Mesothelium lined cystic cavity
Mesothelial lining of hydrocele
Cystic dilatation of epididymis
Cystic dilatation of epididymis
Spermatocele
Ruptured spermatocele
Cyst of tunica albuginea
Images hosted on other servers:
Calcified mass
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Cryptorchid testis with embryonal carcinoma
Contributed by Debra L. Zynger, M.D.
Mixed GCT with predominance of embryonal carcinoma
Mixed GCT with minor component of embryonal carcinoma
Contributed by Debra L. Zynger, M.D.
Solid growth
Glandular growth
Papillary growth
Cellular overlap
Pleomorphic
Admixed with yolk sac tumor
Intratubular
Lymphovascular invasion
Spermatic cord invasion
OCT 3/4
CD30
PLAP
CD117
D2-40
AE1 / AE3
Contributed by Debra L. Zynger, M.D. and @ThatGlassTho on Twitter
Testicular epidermoid cyst
Cyst wall with adjacent normal seminiferous tubule
Lamellar keratin within the cyst
Stratified squamous epithelium with adjacent keratin
Teratoma - epidermoid cyst
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Normal FISH for 12p
Contributed by Veena Maheshwar, M.D., Kiran Alam, M.D., Anshu Jain, M.D.
25 year old man with epididymal mass: filiarial epididymitis
Contributed by Debra L. Zynger, M.D.
Testicular epithelial trophoblastic tumor
Images hosted on other servers:
Well circumscribed intratesticular tumor
Contributed by Rafael E. Jimenez, M.D., M.H.A.
Bland nuclei
Fascicular pattern
Encapsulated tumor
Collagenized stroma
Inhibin
SF1
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MRI: polycyclic mass
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Intrascrotal mass
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Pedunculated mass
Well demarcated margins
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Dense fibrotic tissue
Collagen rich hyalinized fibrotic tissue
CD3
IgG4
CD31
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GCNIS derived adult germ cell tumors
Contributed by Stephanie Siegmund, M.D., Ph.D., Maria Tretiakova, M.D., Ph.D., Alexander Subtelny, M.D., Ph.D. and Michelle Hirsch, M.D., Ph.D.
Prominent, large atypical gonocytes
Pagetoid GCNIS into rete testis
Normal prepubertal testis
GCNIS with adjacent microinvasion
Podoplanin /
D2-40
Membranous
D2-40 IHC
Membranous KIT IHC
Nuclear OCT 3/4 IHC
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Representative aneuploidy and chromosomal abnormalities
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Gonadoblastoma and dysgerminoma in gonadal dysgenesis
Images hosted on other servers:
Gonadoblastoma
Female patient
Contributed by Yale Rosen, M.D. and @SueEPig on Twitter
TB orchitis
Granulomatous orchitis
Images hosted on other servers:
Brucellosis
Contributed by Sean R. Williamson, M.D. and @SueEPig on Twitter
Tuberculosis involving testis and paratestis
Granulomatous orchitis
Contributed by Debra L. Zynger, M.D.
Entrapped glands
Cords, glands and small nests
Gland formation
Entrapped mesothelium
WT1
Calretinin
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Scrotal MRI: cystic lesion
Encysted hydrocele
Images hosted on other servers:
Abdominoscrotal hydrocele
Contributed by Francesca Sanguedolce, M.D., Ph.D.
Connective tissue, mild inflammation
Fibrosis, moderate inflammation
Mesothelial lining
Calretinin
Contributed by Vikas Mehta, M.D. and @katcollmd on Twitter
Seminiferous tubules
Basement membrane deposition
Calretinin
Inhibin A
Collagen IV
PAS
Intratubular large cell hyalinizing Sertoli cell neoplasia
Images hosted on other servers:
Well encapsulated cystic mass
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Testicle after surgery
Contributed by Vikas Mehta, M.D.
Variable sized follicles
Follicles with bland cells
Tumor cells with eosinophilic cytoplasm
Round to oval hyperchromatic nuclei
Contributed by Sara Vargas, M.D.
Ill defined testicular nodules
Images hosted on other servers:
Firm, white tan nodules
Tumor
Contributed by Stephanie Siegmund, M.D., Ph.D.
Calcifications, neutrophils, myxoid stroma
Focus of intratubular tumor
Tumor involving rete testis
Mulberry calcifications
Trabecular architecture
Focal nuclear pleomorphism
Neutrophilic infiltrate
Minimal cytologic atypia
Mulberry calcifications
PRKAR1A loss
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Mass posterior superior to right testis
Huge heterogeneous enhancing mass
Heterogenous echogenicity
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Ulcerated and
fungating tumor
involving scrotum
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Well defined huge solid mass
Case #254
Various images
Vimentin
Desmin
Alpha smooth muscle actin
PAS
PLAP
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Pattern of spindle cells - H&E
Mitotic activity and atypical nuclei
Desmin+, SMA+
Desmin+
SMA+
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CT scan: circumscribed mass
MRI: solid enhancing mass
Ultrasound: mixed echogenic mass
Contributed by Debra L. Zynger, M.D.
Small tumor
Nodular tumor
High risk tumor
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Circumscribed brown tumor
Contributed by Manju Aron, M.D. and Kristine Cornejo, M.D.
Polygonal cells
Eosinophilic cells
Reinke crystals
Inhibin positive
SF1 positive
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Nonhomogeneous right scrotal mass
No evidence of tissue infiltration
Large heterogenous extratesticular mass
CT of paratesticular liposarcoma presenting as hernia
Images hosted on other servers:
Scrotal mass at presentation
Tumor after chemotherapy
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Tumor mass
Yellow and myxoid areas
White yellow to red brown cut surface, marked necrosis
Right paratesticular mass with solid, yellow white, fatty, myxoid areas
Grossly firm tumor
Images hosted on other servers:
Well differentiated liposarcoma:
Atypical spindle cells and lipoblasts
Mature adipocytes and lipoblasts
Well differentiated with dedifferentiated component:
Hypercellular stroma with atypical adipocytes
Atypical adipocytes with enlarged nuclei
Dedifferentiated with leiomyosarcomatous component:
H&E
MDM2+, CDK4+, alpha smooth muscle actin+, desmin+
Myxoid liposarcoma:
Lipoblasts contain lipid vacuoles
Plexiform arrangement of capillaries
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Diffuse large B cell lymphoma
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Diffuse large B cell lymphoma
Peripheral T cell lymphoma
Images hosted on other servers:
Maxillary tumors
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Maxillary tumor: H&E and stains
Images hosted on other servers:
Increased thickness of the left tunica vaginalis
Small nodules
Border indistinctness in the right scrotum
Case #261
AFIP images
Tunica vaginalis
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Radical orchiectomy specimen
Nodular mass at spermatic cord
Extracted tumor adhered strongly to scrotum skin
Contributed by Jennifer Gordetsky, M.D.
Mesothelioma
Case #261
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Epithelial tumor cells
Glandular pattern in desmoplastic stroma
Malignant mesothelial tubular structures
Biphasic exophytic nodule
Papillary structures
Mesothelioma of uncertain malignant potential
Cells are rounded with nuclear atypia
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Renal cell carcinoma metastasis to testis
Lung adenocarcinoma metastasis to testis
Colorectal adenocarcinoma metastasis to testis
Contributed by Debra L. Zynger, M.D.
Metastatic prostatic adenocarcinoma
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Metastatic colorectal adenocarcinoma
Metastatic renal cell carcinoma
Contributed by Gang Wang, M.D., Ph.D.
Metastatic prostatic adenocarcinoma
Involvement of the tubular system
Cribriform pattern
most frequent,
epididymis
involvement
Solid growth pattern
Metastatic ductal adenocarcinoma
Positive for PSA
Positive for ERG
Metastatic renal cell carcinoma, clear cell type
Broad pushing borders
Mixed patterns
Positive for PAX8
Positive for CAIX
adenocarcinoma
Cystic spaces containing mucin
cell carcinoma
Infiltrating and anastomosing nests
Positive for p40
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Well circumscribed lower pole testicular tumor
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Tumor is compressing adjacent tunica
Fascicular and storiform spindle cell arrangement
Insular arrangement of cells in hyaline stroma
Irregular ovoid nuclei with longitudinal grooves
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Area of curvilinear calcification
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Various images
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Right testicular borderline mucinous tumor
Images hosted on other servers:
Cyst wall irregularly thickened and fibrotic
Mucinous epithelium
resembling endocervical
type cells
Images hosted on other servers:
Ultrasound features
Contributed by Vikas Mehta, M.D.
Ectatic blood vessels
Spindle arrangement of tumor cells
SF1 positivity
h-caldesmon negativity
SMA positivity
S100 positivity
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Complex echo pattern
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Epididymal tumor
Microcystic with hemorrhage
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Cystic space with papillary excrescences
Cilia
Case with clear cells
CK7
CD10
Contributed by Delia Perez-Montiel, M.D.
40 year old man
Contributed by Delia Perez-Montiel, M.D.
Images hosted on other servers:
Tumor in undescended testis
Images hosted on other servers:
Spindle cell proliferation
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Scrotal ultrasound
Regressed
primary with
retroperitoneal
metastasis
Contributed by Debra L. Zynger, M.D.
Complete regression (pT0)
Germ cell neoplasia in situ only (pTis)
Partial regression (pT1)
Contributed by Debra L. Zynger, M.D.
Scar
Acellular matrix
Small vessels
Hemosiderin
Germ cell neoplasia in situ
OCT3 / 4
D2-40
CD117
Images hosted on other servers:
Ultrasound with testicle mass
Parietal metastasis
Contributed by Debra L. Zynger, M.D.
pT1a
pT1b
pT2
Images hosted on other servers:
Very large seminoma
Seminoma
Lobulated soft tan to brown tissue
Contributed by Michelle Downes, M.D. and Debra L. Zynger, M.D.
Fibrous septae
Admixed lymphocytes
Large cells with clear cytoplasm
Coagulative necrosis
OCT 3/4
CD117
Granulomatous inflammation
Granuloma
Intratubular seminoma
Rete testis invasion
Rete testis pagetoid spread
Hilar fat invasion
Epididymal invasion
Syncytiotrophoblasts
hCG
Discontinuous spermatic cord invasion
Contributed by Michelle Downes, M.D. and Debra L. Zynger, M.D.
Intraoperative touch prep
Large cells with prominent nucleoli
Tigroid pattern
Images hosted on other servers:
Intratesticular mass
Images hosted on other servers:
WT1+
Contributed by Raman Danrad, M.D.
Ultrasound of left testis
Images hosted on other servers:
Demarcated, bulging, pale yellowish nodules
Sharply demarcated, yellowish white nodule
Contributed by Ritu Bhalla, M.D. and Jian-Hua Qiao, M.D.
Unencapsulated nodule
Seminiferous tubule proliferation
Focal Leydig cells
Hyaline basement membrane deposits
Pseudostratified Sertoli cells
Arrangement of Sertoli cells
Calcification
Hyperplastic Sertoli cells
Atrophic seminiferous tubules
Persistent immature tubules
Hyalinization of basement membrane
Atrophic seminiferous tubules
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Thickened, multilamellar basement membranes
Hyaline core
Contributed by Asmaa Gaber Abdou, M.D.
Sertoli cell only and Leydig cell hyperplasia
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Hypoechoic lesion
Images hosted on other servers:
Tumor in lower pole
Contributed by Thomas Ulbright, M.D. and Case #18
Architectural patterns
Cords
Tubules
Tubopapillary
Macrocystic
Microcystic
Architectural patterns
Whorled
Trabecular
Sclerosing Sertoli cell tumor
Various images
Cells
Abundant clear cytoplasm (most common)
Heavily lipidized
Malignant
Marked cytologic atypia
Tumor necrosis
Lymphovascular invasion
High N/C ratio,
increased
mitotic / apoptotic
activity
Contributed by Indiana University School of Medicine
Tubular formations, monotonous small cells (Pap)
Papillary groups and discohesive cells (Pap)
Images hosted on other servers:
Well circumscribed multicystic mass
Images hosted on other servers:
Columnar epididymal type epithelium
Cystic duct
Mass blends with ducts in epididymal tail
Images hosted on other servers:
Ultrasound images
Contributed by Anil Parwani, M.D., Ph.D., M.B.A.
Orchiectomy
with spermatocele
Contributed by Anil Parwani, M.D., Ph.D., M.B.A.
Spermatocele with adjacent epididymis
Cuboidal epithelium
Ciliated columnar epithelium
Flattened epithelium
Aggregate of spermatozoa
Macrophages containing spermatozoa
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ST (arrow) and testis (*)
AFIP images
Mucoid tumor
Images hosted on other servers:
ST (arrow)
Cystic and mucoid tumor
Contributed by Maurizio Colecchia, M.D., Case #448 and AFIP images
Lobulated architecture
Tripartite cytology
Prevalent intermediate sized cells
Mitoses and apoptotic bodies
Short fibrous bands
Spireme-like chromatin
Edema and microcysts
Edema and nests
Intratubular growth
OCT3/4
CD45
Diffuse growth pattern
Focal pseudoglandular pattern
Cystic pattern
Polymorphic cell population
Small nests, trabeculae, clusters and single cells
Filamentous chromatin
Normal spermatogenesis
Desmin+
Tumor nests and
cords mixed with
lymphocytes
Prominent
granulomatous
reaction and
lymphoid infiltrate
Intratubular component
AFIP images
Intercellular bridge
Nest of spermatocytic seminoma
Case #309
Contributed by Debra L. Zynger, M.D.
Complete regression (pT0)
Germ cell neoplasia in situ only (pTis)
Partial regression (pT1)
Teratoma (pT1)
Teratoma and EC (pT1)
Seminoma (pT1a)
Seminoma (pT1b)
Mixed germ cell tumor (pT2)
Seminoma (pT2)
No residual testis tumor (ypT0)
No residual node tumor (ypN0)
Lymph node with residual tumor (ypN1 - 3)
Discontinuous spermatic cord (pM1)
Contributed by Debra L. Zynger, M.D.
Lymphovascular invasion (pT2)
Lymphovascular invasion (pT2)
Tunica vaginalis invasion (pT2)
Epididymal invasion (pT2)
Hilar soft tissue invasion (pT2)
Lymph node metastasis (pN1)
Post treatment node (ypN0)
Post treatment node (ypN1)
Discontinuous spermatic cord invasion (pM1)
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Testicular teratoma diagnosed in utero
Demonstrating vascularity of testicular teratoma with calcifications
Contributed by Debra L. Zynger, M.D.
Teratoma (100%)
Mixed GCT
Contributed by Debra L. Zynger, M.D.
Cartilage surrounded by mitotically active spindle cells
Gastrointestinal epithelium
Squamous epithelium
Cellular mesenchyme
Loose mesenchyme
Neuroectoderm
Contributed by Christopher Dall, M.D. and Debra L. Zynger, M.D.
Retroperitoneal sarcoma, NOS
Lung rhabdo-
myosarcoma
Iliac leiomyosarcoma
Embryonic type neuroectodermal tumor
Contributed by Christopher Dall, M.D. and Debra L. Zynger, M.D.
Metastatic rhabdomyosarcoma
Metastatic chondrosarcoma
Metastatic sarcoma, NOS
Embryonic type neuroectodermal tumor within testis
AFIP images
Solid tan mass
Contributed by Sounak Gupta, M.B.B.S, Ph.D. and Rafael E. Jimenez, M.D.
Epidermoid cyst and NET
Retraction artifact
Multiple solid nests
Insular growth pattern
Nests of tumor cells
Testicular NET
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Dexamethasone treatment
Large TTAGS
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Well circumscribed,
noncapsulated, solid
and lobulated brown lesion
Images hosted on other servers:
H&E
H&E, IHC, CD56
H&E
Case #279
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Bell clapper deformity
leading to intravaginal
testicular torsion
Contributed by Raman Danrad, M.D.
Ultrasound of bilateral testis
Ultrasound of right normal testis
Ultrasound of left torsed testis
Images hosted on other servers:
Twisting of spermatic cord
Images hosted on other servers:
Smooth external surface of torsed testis
Dark red hemorrhagic cut surface
Contributed by Ritu Bhalla, M.D.
Congestion
Hilar hemorrhage
Sloughing of cells
Interstitial hemorrhage
Residual germ cells
Infarcted tubules
Necrotic parenchyma
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Left sided grade 3 varicocele
Color Doppler ultrasonography of varicocele
Contributed by Kenneth A. Iczkowski, M.D.
Orchiectomy specimen in a 30 year old with atrophic testis and varicocele
Case #328
Testicular heterogeneous hypoechoic lesion
Case #328
Case #328
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Vasitis nodosa
Contributed by Aida Valencia, M.D. and Jennifer Gordetsky, M.D.
Numerous fibrovascular cores
Background macrophages
Broad papillae
Papillae with myxoid stroma
Nonpsammomatous calcifications
Calretinin
WT1
D2-40
Mesothelioma
Images hosted on other servers:
TRAF7 and CDC42 somatic mutations
Contributed by Debra L. Zynger, M.D.
Mixed germ cell tumor, postpubertal with varying % of yolk sac tumor
Contributed by João Lobo, M.D. and Rui Henrique, M.D., Ph.D.
Microcystic pattern
Hyaline globules
Glandular pattern
Schiller-Duval bodies
Metastasis
Amin: 2022
Behnke: 2018
Cheng: 2019
Colecchia : 2016
IARC: 2022
Manuel: 2019
Nistal: 2017
Ulbright: 2014
Ulbright: 2022
VandenBussche: 2022
Wobker: 2021
Yang: 2020
Zhou: 2022
Zhou: 2022
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