Adrenal gland and paraganglia
Other benign cortical lesions
Adenomatoid tumor of adrenal gland

Author: Lan L. Gellert, M.D., Ph.D. (see Authors page)

Revised: 11 August 2016, last major update August 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Adrenal Adenomatoid Tumor

Definition / General
  • Benign neoplasm of mesothelial origin
Essential Features
  • Benign neoplasm of mesothelial origin
  • Very rare, mostly incidental finding
  • In the differential diagnosis of adrenal mass
  • Immunostains help establish the diagnosis
Epidemiology
  • Mean age 41 years, range 31-64 years
  • 90% male
Etiology
Clinical Features
  • Mostly asymptomatic and discovered incidentally
Prognostic Factors
  • Metastasis or recurrences have not been reported
Case Reports
Treatment
  • Surgical excision
Clinical Images
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Adenomatoid tumor in left adrenal gland

Well circumscribed,
expansile hypodense mass
in right adrenal gland

Gross Description
  • 1-4 cm, well circumscribed, white-tan-gray, and occasional cystic mass
Gross Images
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Adenomatoid tumor in left adrenal gland

Cut surface of cystic lymphangioma-like
adrenal adenomatoid tumor

Micro Description
  • Adenoid, angiomatoid, cystic and solid patterns of anastomosing glands and tubules of variable size
  • Flat to low cuboidal neoplastic cells with occasional cytoplasmic vacuoles and signet ring cell like morphology
  • Cells have low nuclear / cytoplasmic ratio
  • No or rare mitotic activity
  • Involves adrenal tissue and often extends into adjacent fat
Micro Images
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H&E and immunostains of adrenal adenomatoid tumor

Cystic lymphangioma-like adenomatoid tumor

Tumor admixed with
lymphoid follicular hyperplasia

Positive Stains
Negative Stains
Electron Microscopy Description
  • Well formed desmosomes, extensively developed microvilli
    Differential Diagnosis