Adrenal gland & paraganglia
Other tumors
Adenomatoid tumor

Topic Completed: 1 August 2016

Minor changes: 16 January 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Adrenal adenomatoid tumor

Lan L. Gellert, M.D., Ph.D.
Page views in 2019: 700
Page views in 2020 to date: 535
Cite this page: Gellert LL. Adenomatoid tumor. website. Accessed October 20th, 2020.
Definition / general
  • Benign neoplasm of mesothelial origin
Essential features
  • Benign neoplasm of mesothelial origin
  • Very rare, mostly incidental finding
  • In the differential diagnosis of adrenal mass
  • Immunostains help establish the diagnosis
  • Mean age 41 years, range 31-64 years
  • 90% male
Clinical features
  • Mostly asymptomatic and discovered incidentally
Prognostic factors
  • Metastasis or recurrences have not been reported
Case reports
  • Surgical excision
Clinical images

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Adenomatoid tumor in left adrenal gland

Well circumscribed,
expansile hypodense mass
in right adrenal gland

Gross description
  • 1-4 cm, well circumscribed, white-tan-gray, and occasional cystic mass
Gross images

Images hosted on other servers:

Adenomatoid tumor in left adrenal gland

Cut surface of cystic lymphangioma-like
adrenal adenomatoid tumor

Microscopic (histologic) description
  • Adenoid, angiomatoid, cystic and solid patterns of anastomosing glands and tubules of variable size
  • Flat to low cuboidal neoplastic cells with occasional cytoplasmic vacuoles and signet ring cell like morphology
  • Cells have low nuclear / cytoplasmic ratio
  • No or rare mitotic activity
  • Involves adrenal tissue and often extends into adjacent fat
Microscopic (histologic) images

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H&E and immunostains of adrenal adenomatoid tumor

Cystic lymphangioma-like adenomatoid tumor

Tumor admixed with
lymphoid follicular hyperplasia

Positive stains
Negative stains
Electron microscopy description
  • Well formed desmosomes, extensively developed microvilli
    Differential diagnosis
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