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Adrenal gland and paraganglia

Congenital anomalies

Adrenal cytomegaly

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 February 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● Relatively common finding within fetal cortex in newborns, particularly premature infants (3-7%) or infants with Rh incompatibility
● May be associated with Beckwith-Wiedemann syndrome
● Cells do NOT represent carcinoma in situ
● Pseudoinclusions (Arch Pathol Lab Med 1981;105:358)

Case reports

● Occurrence in two, apparently normal adults (Arch Pathol Lab Med 1986;110:1072)

Gross description

● Hyperplastic adrenal glands

Micro description

● Numerous, markedly enlarged (up to 150 microns) and bizarre polyhedral cells with eosinophilic, granular cytoplasm and large, hyperchromatic nuclei with pseudoinclusions in adrenal cortex
● No / rare mitotic figures

Differential diagnosis

CMV infection - usually infants, basophilic cytoplasm and large intranuclear inclusion surrounded by a clear halo

End of Adrenal gland and paraganglia > Congenital anomalies > Adrenal cytomegaly

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