Adrenal gland and paraganglia
Congenital anomalies
Adrenal cytomegaly

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 January 2016, last major update February 2005

Copyright: (c) 2002-2016,, Inc.

Cite this page: Adrenal cytomegaly. website. Accessed October 18th, 2018.
Definition / general
  • Relatively common finding within fetal cortex in newborns, particularly premature infants (3-7%) or infants with Rh incompatibility
  • May be associated with Beckwith-Wiedemann syndrome
  • Cells do NOT represent carcinoma in situ
  • Pseudoinclusions (Arch Pathol Lab Med 1981;105:358)
Case reports
Gross description
  • Hyperplastic adrenal glands
Microscopic (histologic) description
  • Numerous, markedly enlarged (up to 150 microns) and bizarre polyhedral cells with eosinophilic, granular cytoplasm and large, hyperchromatic nuclei with pseudoinclusions in adrenal cortex
  • No / rare mitotic figures
Differential diagnosis
  • CMV infection - usually infants, basophilic cytoplasm and large intranuclear inclusion surrounded by a clear halo