Adrenal gland and paraganglia - Adrenal cytomegaly

Home Chapter Home Jobs Conferences Fellowships Books

Adrenal gland and paraganglia

Congenital anomalies

Adrenal cytomegaly

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 February 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Relatively common finding within fetal cortex in newborns, particularly premature infants (3-7%) or infants with Rh incompatibility
● May be associated with Beckwith-Wiedemann syndrome
● Cells do NOT represent carcinoma in situ
● Pseudoinclusions (Arch Pathol Lab Med 1981;105:358)

Case reports
=========================================================================

● Occurrence in two, apparently normal adults (Arch Pathol Lab Med 1986;110:1072)

Gross description
=========================================================================

● Hyperplastic adrenal glands

Micro description
=========================================================================

● Numerous, markedly enlarged (up to 150 microns) and bizarre polyhedral cells with eosinophilic, granular cytoplasm and large, hyperchromatic nuclei with pseudoinclusions in adrenal cortex
● No / rare mitotic figures

Differential diagnosis
=========================================================================

● CMV infection - usually infants, basophilic cytoplasm and large intranuclear inclusion surrounded by a clear halo

End of Adrenal gland and paraganglia > Congenital anomalies > Adrenal cytomegaly

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).