Adrenal gland and paraganglia
Adrenal hyperfunction / hyperplasia
Adrenal cytomegaly

Topic Completed: 1 February 2005

Minor changes: 15 January 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Adrenal cytomegaly

Nat Pernick, M.D.
Page views in 2019: 384
Page views in 2020 to date: 137
Cite this page: Pernick N. Adrenal cytomegaly. website. Accessed May 27th, 2020.
Definition / general
  • Relatively common finding within fetal cortex in newborns, particularly premature infants (3-7%) or infants with Rh incompatibility
  • May be associated with Beckwith-Wiedemann syndrome
  • Cells do NOT represent carcinoma in situ
  • Pseudoinclusions (Arch Pathol Lab Med 1981;105:358)
Case reports
Gross description
  • Hyperplastic adrenal glands
Microscopic (histologic) description
  • Numerous, markedly enlarged (up to 150 microns) and bizarre polyhedral cells with eosinophilic, granular cytoplasm and large, hyperchromatic nuclei with pseudoinclusions in adrenal cortex
  • No / rare mitotic figures
Differential diagnosis
  • CMV infection - usually infants, basophilic cytoplasm and large intranuclear inclusion surrounded by a clear halo
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