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Adrenal gland and paraganglia

Adrenal insufficiency


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 February 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● Rarely causes cortical hypofunction, only if extensive bilateral involvement
● Usually associated with systemic amyloidosis-AA type
● 68% of consecutive autopsies had adrenal amyloid deposits, often multinodular and probably due to aging

Gross description

● Adrenal gland normal or enlarged; gray-yellow cut surface

Micro description

● Typically affects zona fasciculata and reticularis
● Acellular salmon-pink amorphous material is present between cortical cells, which ultimately become atrophic
● Amyloidosis-AL type is typically deposited intravascularly

Virtual slides


Differential diagnosis

● Infarction related changes

End of Adrenal gland and paraganglia > Adrenal insufficiency > Amyloidosis

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