Adrenal gland and paraganglia
Adrenal insufficiency

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 25 January 2016, last major update February 2005

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Amyloidosis adrenal
Cite this page: Amyloidosis. website. Accessed July 21st, 2018.
Definition / general
  • Rarely causes cortical hypofunction, only if extensive bilateral involvement
  • Usually associated with systemic amyloidosis-AA type
  • 68% of consecutive autopsies had adrenal amyloid deposits, often multinodular and probably due to aging
Microscopic (histologic) description
  • Typically affects zona fasciculata and reticularis
  • Acellular salmon-pink amorphous material is present between cortical cells, which ultimately become atrophic
  • Amyloidosis-AL type is typically deposited intravascularly
Virtual slides

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Differential diagnosis
  • Infarction related changes