Adrenal gland and paraganglia
Adrenal insufficiency

Topic Completed: 1 February 2005

Revised: 29 May 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Amyloidosis adrenal

Nat Pernick, M.D.
Page views in 2018: 166
Page views in 2019 to date: 152
Cite this page: Pernick N. Amyloidosis. website. Accessed December 12th, 2019.
Definition / general
  • Rarely causes cortical hypofunction, only if extensive bilateral involvement
  • Usually associated with systemic amyloidosis-AA type
  • 68% of consecutive autopsies had adrenal amyloid deposits, often multinodular and probably due to aging
Microscopic (histologic) description
  • Typically affects zona fasciculata and reticularis
  • Acellular salmon-pink amorphous material is present between cortical cells, which ultimately become atrophic
  • Amyloidosis-AL type is typically deposited intravascularly
Differential diagnosis
  • Infarction related changes
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