Adrenal related
Captopril suppression test

Author: Renu Virk, M.D. (see Authors page)

Revised: 26 January 2016, last major update February 2010

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Captopril suppression test
Cite this page: Captopril suppression test. website. Accessed October 19th, 2018.
Definition / general

  • Captopril inhibits conversion of angiotensin I to angiotensin II, thereby decreasing aldosterone production in normal individuals
  • In patients with primary hyperaldosteronism, the plasma aldosterone levels are NOT suppressed by captopril

  • Measure plasma aldosterone levels at baseline and 2 hours after patient takes 25mg of captopril orally

Normal range:
  • Plasma aldosterone concentration (PAC) <15 ng/dl (416pmol.L) and PAC to plasma renin activity (PRA) ratio less than 50

Adverse effects:
  • Marked hypotension may occur due to captopril intake
  • Blood pressure should be monitored regularly
Additional references