Home   Chapter Home   Jobs   Conferences   Fellowships   Books

 

 

Advertisement

 

Adrenal Gland

Captopril suppression test

 

Author: Renu Virk, M.D. (see Authors page)

Revised: 21 September 2012, last major update - February 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Indication

=========================================================================

● Confirms the diagnosis of primary (hyper) aldosteronism

● One of four tests recommended for screening or confirmation: also oral sodium loading, saline infusion and fludrocortisone suppression (Horm Metab Res 2010 Jan 29 [Epub ahead of print])

● As effective as sodium loading in confirming the diagnosis of primary aldosteronism (Hypertension 2001; 37:1440, Curr Hypertens Rep 2002;4:245)

● Note: Captopril challenge test is used to diagnose renal artery stenosis, differs in that plasma renin (not aldosterone) is measured (Wikipedia)

 

Rationale

=========================================================================

● Captopril inhibits conversion of angiotensin I to angiotensin II, thereby decreasing aldosterone production in normal individuals; in patients with primary hyperaldosteronism, the plasma aldosterone levels are NOT suppressed by captopril

 

Methodology

=========================================================================

Measure plasma aldosterone levels at baseline and 2 hours after patient takes 25mg of captopril orally

 

Normal range

=========================================================================

● Plasma aldosterone concentration (PAC) <15 ng/dl (416pmol.L) and PAC to plasma renin activity (PRA) ratio less than 50

 

Adverse effects

=========================================================================

● Marked hypotension may occur due to captopril intake

● Blood pressure should be monitored regularly

 

Additional references

=========================================================================

eMedicine (primary hyperaldosteronism)

 

End of Adrenal Gland > Captopril suppression test

 

 

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment.  This website should not be used as a substitute for the advice of a licensed physician.

 

All information on this website is protected by copyright of PathologyOutlines.com, Inc.  Information from third parties may also be protected by copyright.  Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).