Adrenal gland and paraganglia
Adrenocortical adenoma - children
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 21 February 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Rare, 25 cases annually in US
- Usually hormone-related symptoms with virilization, Cushing’s syndrome and mixed endocrine syndromes; rarely feminization or Conn’s syndrome
- 75% of adrenocortical neoplasms in children are carcinomas, although only 31% of histologically malignant tumors had clinically malignant behavior
- Malignant behavior associated with vena cava invasion, tumor necrosis, > 15 mitotic figures/20 HPF, although cannot rely on a single histological feature
- Proposed criteria for malignancy in children: > 400g, > 10.5 cm, extension into adjacent soft tissue / organs, extension into vena cava, capsular invasion, vascular invasion, tumor necrosis, > 15 mitotic figures/20 HPF and atypical mitotic figures (Am J Surg Pathol 2003;27:867)
End of Adrenal gland and paraganglia > Adrenocortical adenoma - children
- Inhibin, vimentin, CK5, p53 (focal) and Ki-67 (focal)
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other