Adrenal gland and paraganglia
Adrenal insufficiency
Drugs causing adrenal insufficiency

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 25 January 2016, last major update February 2005

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PubMed Search: Drugs adrenal insufficiency
Table of Contents
General
General
  • Aminoglutethimide: inhibits enzyme converting cholesterol to pregenolone, causes decrease in cortisol and aldosterone
  • Metapyrone: inhibits 11 beta hydroxylase, which inhibits cortisol and aldosterone synthesis
  • Mitotane: cytotoxic to zona fasciculata and reticularis, produces medical adrenalectomy; produces atrophic adrenal glands with fibrosis and residual islands of cortical cells