Adrenal gland and paraganglia
Adrenal insufficiency
Drugs causing adrenal insufficiency

Topic Completed: 1 February 2005

Revised: 29 May 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Drugs adrenal insufficiency

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Drugs causing adrenal insufficiency. website. Accessed December 13th, 2019.
Definition / general
  • Aminoglutethimide: inhibits enzyme converting cholesterol to pregenolone, causes decrease in cortisol and aldosterone
  • Metapyrone: inhibits 11 beta hydroxylase, which inhibits cortisol and aldosterone synthesis
  • Mitotane: cytotoxic to zona fasciculata and reticularis, produces medical adrenalectomy; produces atrophic adrenal glands with fibrosis and residual islands of cortical cells
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