Adrenal gland and paraganglia
Drugs causing adrenal insufficiency
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 February 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
● Aminoglutethimide: inhibits enzyme converting cholesterol to pregenolone, causes decrease in cortisol and aldosterone
● Metapyrone: inhibits 11 beta hydroxylase, which inhibits cortisol and aldosterone synthesis
● Mitotane: cytotoxic to zona fasciculata and reticularis, produces medical adrenalectomy; produces atrophic adrenal glands with fibrosis and residual islands of cortical cells
End of Adrenal gland and paraganglia > Adrenal insufficiency > Drugs causing adrenal insufficiency
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