Table of ContentsDefinition / general
Cite this page: Pernick N. Drugs causing adrenal insufficiency. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenaldrugs.html. Accessed December 13th, 2019.
Definition / general
- Aminoglutethimide: inhibits enzyme converting cholesterol to pregenolone, causes decrease in cortisol and aldosterone
- Metapyrone: inhibits 11 beta hydroxylase, which inhibits cortisol and aldosterone synthesis
- Mitotane: cytotoxic to zona fasciculata and reticularis, produces medical adrenalectomy; produces atrophic adrenal glands with fibrosis and residual islands of cortical cells