Adrenal gland and paraganglia
Other benign cortical lesions
Hemangioma

Author: Lan L. Gellert, M.D., Ph.D. (see Authors page)

Revised: 15 November 2016, last major update November 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed search: hemangioma [title] adrenal gland

Cite this page: Hemangioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenalhemangioma.html. Accessed December 3rd, 2016.
Definition / General
  • Rare nonfunctioning benign tumors arising from endothelial cells that line blood vessels
  • Usually cavernous, unilateral lesion
Essential Features
  • Rare nonfunctioning benign tumors arising from endothelial cells that line blood vessels
  • Typically incidental finding during imaging studies
  • Multiple dilated vascular spaces lined by a single layer of vascular endothelium
  • Usually cavernous and rarely capillary in type
  • Cystic lining positive for CD34 and CD31
Epidemiology
  • Peak incidence between the fifth and seventh decades
  • Approximately 2:1 female to male ratio
Etiology
  • Possibly congenital with involvement of hereditary factors and ectasia of blood vessels (JOP 2014;15:254)
Clinical Features
  • Mostly asymptomatic
  • Usually incidental finding during imaging studies
Radiology Description
  • Typical CT finding: heterogeneous, hypodense lesion with variable calcification
Case Reports
Treatment
  • Surgical excision, especially for large lesions, to rule out malignant disease and preclude spontaneous rupture
Clinical Images
Images hosted on other servers:

Large left adrenal lesion

Voluminous well circumscribed mass

Cystic multiseptated lesion in right adrenal region

Lobulated multicystic lesion of abdomen


High signal intensity mass

Various images

Large mass with hypodense center

Gross Description
  • Well circumscribed, encapsulated mass
Gross Images
Images hosted on other servers:

Resected adrenal gland

Intraoperative view

Gross appearance
showing a voluminous
well delineated mass


Resected adrenal
gland with a
smooth surface
and adrenal vein

Sectioning shows an ill defined, congested lesion

Gross specimen showing a well delineated mass

Micro Description
  • Multiple dilated vascular channels lined by a single layer of vascular endothelium
  • Necrosis, thrombosis, calcification or hemorrhage occasionally present
  • Usually cavernous and rarely capillary in type
  • Adjacent normal adrenal gland parenchyma
Micro Images
Images hosted on PathOut server:

Contributed by Lan L. Gellert, M.D., Ph.D.

Finger hemangiomas - benign vascular proliferation lined by bland single layer endothelial cells with intraluminal red blood cells

Nasal cavity hemangiomas - morphologically similar to an adrenal gland hemangioma

Orbit hemangioma



Images hosted on other servers:

Blood filled dilated vascular spaces with single lining of mature endothelial cells

Various images

Thick walled, large
interconnecting
vascular channels
filled with blood
Positive Stains
Negative Stains
Differential Diagnosis