Adrenal gland and paraganglia
Congenital anomalies
Hereditary unresponsiveness to ACTH

Author: Nat Pernick, M.D. (see Authors page)

Revised: 15 January 2016, last major update February 2005

Copyright: (c) 2002-2016,, Inc.

Cite this page: Hereditary unresponsiveness to ACTH. website. Accessed October 18th, 2018.
Definition / general
  • Rare; due to abnormalities of ACTH receptor in adrenocortical cells
  • Seizures, hypoglycemia, muscle weakness and hyperpigmentation similar to Addisons disease
  • Low plasma cortisol levels, increased serum ACTH
Microscopic (histologic) description
  • Normal zona glomerulosa, atrophic zona fasciculata and reticularis