Adrenal gland and paraganglia
Congenital anomalies
Hereditary unresponsiveness to ACTH

Topic Completed: 1 February 2005

Revised: 29 May 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Hereditary unresponsiveness to ACTH

Nat Pernick, M.D.
Page views in 2018: 50
Page views in 2019 to date: 50
Cite this page: Pernick N. Hereditary unresponsiveness to ACTH. website. Accessed December 12th, 2019.
Definition / general
  • Rare; due to abnormalities of ACTH receptor in adrenocortical cells
  • Seizures, hypoglycemia, muscle weakness and hyperpigmentation similar to Addisons disease
  • Low plasma cortisol levels, increased serum ACTH
Microscopic (histologic) description
  • Normal zona glomerulosa, atrophic zona fasciculata and reticularis
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