Adrenal gland and paraganglia
Adrenal insufficiency
Isolated mineralocorticoid deficiency

Topic Completed: 1 February 2005

Minor changes: 4 June 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Isolated mineralocorticoid deficiency

Nat Pernick, M.D.
Page views in 2019: 105
Page views in 2020 to date: 57
Table of Contents
Definition / general
Cite this page: Pernick N. Isolated mineralocorticoid deficiency. website. Accessed May 30th, 2020.
Definition / general
  • Deficiency of aldosterone production by zona glomerulosa
  • Usually due to impaired release of renin from kidney due to diabetes mellitus, autoimmune disease, amyloidosis or sickle cell anemia; also heparin, rarely tumors or idiopathic
  • Primary (idiopathic) hypoaldosteronism may be due to autosomal recessive disorder associated with deficiency in CYP11B2 enzyme (converts 18-hydroxyl group to aldehyde at end of aldosterone biosynthesis)
  • Infants have failure to thrive, recurrent dehydration and salt wasting
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