Adrenal gland and paraganglia
Adrenal insufficiency
Isolated mineralocorticoid deficiency

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 25 January 2016, last major update February 2005

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PubMed Search: Isolated mineralocorticoid deficiency
Table of Contents
Definition / General
Definition / General
  • Deficiency of aldosterone production by zona glomerulosa
  • Usually due to impaired release of renin from kidney due to diabetes mellitus, autoimmune disease, amyloidosis or sickle cell anemia; also heparin, rarely tumors or idiopathic
  • Primary (idiopathic) hypoaldosteronism may be due to autosomal recessive disorder associated with deficiency in CYP11B2 enzyme (converts 18-hydroxyl group to aldehyde at end of aldosterone biosynthesis)
  • Infants have failure to thrive, recurrent dehydration and salt wasting