Table of ContentsDefinition / General
Cite this page: Isolated mineralocorticoid deficiency. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenalisolatedmineralocorticoid.html. Accessed December 4th, 2016.
Definition / General
- Deficiency of aldosterone production by zona glomerulosa
- Usually due to impaired release of renin from kidney due to diabetes mellitus, autoimmune disease, amyloidosis or sickle cell anemia; also heparin, rarely tumors or idiopathic
- Primary (idiopathic) hypoaldosteronism may be due to autosomal recessive disorder associated with deficiency in CYP11B2 enzyme (converts 18-hydroxyl group to aldehyde at end of aldosterone biosynthesis)
- Infants have failure to thrive, recurrent dehydration and salt wasting