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Adrenal gland and paraganglia

Adrenal insufficiency

Isolated mineralocorticoid deficiency


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 February 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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● Deficiency of aldosterone production by zona glomerulosa
● Usually due to impaired release of renin from kidney due to diabetes mellitus, autoimmune disease, amyloidosis or sickle cell anemia; also heparin, rarely tumors or idiopathic
● Primary (idiopathic) hypoaldosteronism may be due to autosomal recessive disorder associated with deficiency in CYP11B2 enzyme (converts 18-hydroxyl group to aldehyde at end of aldosterone biosynthesis)
● Infants have failure to thrive, recurrent dehydration and salt wasting

End of Adrenal gland and paraganglia > Adrenal insufficiency > Isolated mineralocorticoid deficiency


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