Adrenal gland
Other benign cortical lesions
Massive macronodular adrenocortical disease

Author: Lan L. Gellert, M.D., Ph.D. (see Authors page)

Revised: 14 January 2017, last major update January 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Massive Macronodular Adrenocortical Disease
Cite this page: Massive macronodular adrenocortical disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenalmassivemacronodular.html. Accessed February 27th, 2017.
Definition / General
Essential Features
  • ACTH independent multinodular adrenocortical proliferation
  • Usually bilateral
  • Occasionally associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) or McCune-Albright syndrome
Clinical Features
  • Usually present with either typical or atypical Cushing syndrome
Case Reports
Treatment
  • Adrenalectomy
Clinical Images

Images hosted on other servers:

Missing Image

Macronodular adrenocortical
hyperplasia of the zona reticularis

Gross Description
  • Glands up to 180 g, nodules up to 4 cm and nonnodular cortex may be atrophic
Gross Images

Images hosted on other servers:

Missing Image

AIMAH patient 1

Missing Image

AIMAH patient 2

Micro Description
  • Predominantly diffuse and vaguely nodular proliferation of clear cortical cells
Micro Images

Images hosted on other servers:

Missing Image

A quantitative RT-PCR array

Positive Stains
Differential Diagnosis