Adrenal gland and paraganglia
Other benign cortical lesions
Massive macronodular adrenal cortical disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 15 January 2016, last major update February 2005

Copyright: (c) 2002-2016,, Inc.

Cite this page: Massive macronodular adrenal cortical disease. website. Accessed December 2nd, 2016.
Definition / General
  • ACTH independent, may involve only a single gland
  • Clinically resembles a neoplasm
  • Bimodal age distribution: newborns (associated with McCune-Albright syndrome) and age 40+; rarely familial
Gross Description
  • Glands up to 180 g together, nodules up to 4 cm and non-nodular cortex may be atrophic
Micro Description
  • Clear cells or compact cells