Adrenal gland and paraganglia
Other adrenal malignancies
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 21 March 2013, last major update February 2005
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Common at autopsy, usually bilateral
- Most common primary sites are breast or lung; also GI tract, melanoma, renal cell carcinoma, thyroid and contralateral adrenal gland
- Usually does not affect adrenal function; may cause adrenal insufficiency if extensive (replacing 80%+ of adrenal gland)
- Single or multiple firm masses replacing some or all of adrenal gland
- Hemorrhage and necrosis in larger metastases
- Tumors are tan-brown to black
End of Adrenal gland and paraganglia > Other adrenal malignancies > Metastases
- Adrenocortical carcinoma - melanA+, inhibin+, calretinin+, synaptophysin+, keratin- and EMA-; metastases are usually opposite
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