Adrenal gland
Other benign cortical lesions
Ovarian thecal metaplasia

Author: Lan L. Gellert, M.D., Ph.D. (see Authors page)

Revised: 1 March 2017, last major update February 2017

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: ovarian thecal metaplasia

Cite this page: Ovarian thecal metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenalovarianthecal.html. Accessed April 24th, 2017.
Definition / General
  • Benign proliferation of radial scar-like fibroblastic / myofibroblastic cells
  • Usually located just beneath the adrenal capsule
Essential Features
  • Benign proliferation of radial scar-like fibroblastic / myofibroblastic cells
  • Usually located just beneath the adrenal capsule
  • Mostly in postmenopausal women; rare in men
  • May be due to metaplasia from adrenal capsule mesenchymal cells due to unopposed pituitary gonadotropin during menopause
Epidemiology
  • Mostly in postmenopausal women; rare in men
Etiology
  • May be due to metaplasia from adrenal capsule mesenchymal cells due to unopposed pituitary gonadotropin during menopause
Case Reports
Treatment
  • Surgical excision for definite pathologic diagnosis
Clinical Images

Images hosted on other servers:

Well circumscribed hypoechoic oval shaped nodule

Right adrenal oval mass

Right adrenal mass (arrow)

Gross Description
  • Multiple bilateral nodules in adrenal cortex, grossly visible (up to 2 cm) or microscopic
Micro Description
  • Proliferation of spindle cells located just beneath the capsule, surrounding small nests of cortical cells
  • Nodular proliferation of radial scar-like spindle cell fibroblastic / myofibroblastic cells
Micro Images

Images hosted on other servers:

H&E stained sections of a tumor

Fig 1: pancreatic ductuloinsular complexes;
2A: somatostatin+;
2B: pancreatic polypeptide+;
3: adrenal gland with nodules composed of nests of oval / spindle cells with bland nuclei,
surrounded by eosinophilic hyalinized stroma; inset: cells are progesterone receptor+;
4: adrenal gland lesion has individual cells surrounded by reticulin fibers; arrows:
reticulin surrounds nests, not individual cells, of entrapped normal cortical cells

Positive Stains
Negative Stains