Adrenal gland and paraganglia
Other benign cortical lesions
Ovarian thecal metaplasia


Topic Completed: 1 February 2017

Revised: 4 June 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed search: ovarian thecal metaplasia

Lan L. Gellert, M.D., Ph.D.
Page views in 2018: 198
Page views in 2019 to date: 105
Cite this page: Gellert LL. Ovarian thecal metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenalovarianthecal.html. Accessed July 16th, 2019.
Definition / general
  • Benign proliferation of radial scar-like fibroblastic / myofibroblastic cells
  • Usually located just beneath the adrenal capsule
Essential features
  • Benign proliferation of radial scar-like fibroblastic / myofibroblastic cells
  • Usually located just beneath the adrenal capsule
  • Mostly in postmenopausal women; rare in men
  • May be due to metaplasia from adrenal capsule mesenchymal cells due to unopposed pituitary gonadotropin during menopause
Epidemiology
  • Mostly in postmenopausal women; rare in men
Etiology
  • May be due to metaplasia from adrenal capsule mesenchymal cells due to unopposed pituitary gonadotropin during menopause
Radiology images

Images hosted on other servers:

Well circumscribed hypoechoic oval shaped nodule

Right adrenal oval mass

Right adrenal mass (arrow)

Case reports
Treatment
  • Surgical excision for definite pathologic diagnosis
Gross description
  • Multiple bilateral nodules in adrenal cortex, grossly visible (up to 2 cm) or microscopic
Microscopic (histologic) description
  • Proliferation of spindle cells located just beneath the capsule, surrounding small nests of cortical cells
  • Nodular proliferation of radial scar-like spindle cell fibroblastic / myofibroblastic cells
Microscopic (histologic) images

Images hosted on other servers:

H&E stained sections of a tumor

Fig 1: pancreatic ductuloinsular complexes;
2A: somatostatin+;
2B: pancreatic polypeptide+;
3: adrenal gland with nodules composed of nests of oval / spindle cells with bland nuclei,
surrounded by eosinophilic hyalinized stroma; inset: cells are progesterone receptor+;
4: adrenal gland lesion has individual cells surrounded by reticulin fibers; arrows:
reticulin surrounds nests, not individual cells, of entrapped normal cortical cells

Positive stains
Negative stains
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