Adrenal gland and paraganglia
Paraganglia
Hyperplasia

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 January 2016, last major update February 2005

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Hyperplasia [title] adrenal
Definition / General
  • Usually in carotid bodies (may be due to chronic hypoxemia); associated with high altitude, chronic obstructive pulmonary disease, systemic hypertension, cystic fibrosis and cyanotic congenital heart disease
  • May also affect vagal and aorticopulmonary paraganglia
Gross Description
  • Weight over 30g
  • Diameter > 5 mm
Micro Description
  • Increased number of lobules, some confluent, composed of increased numbers of sustentacular cells and chief cells with hyperchromatic and mildly enlarged nuclei
Differential Diagnosis
  • Paraganglioma: usually > 300 mg, have higher density of chief cells