Adrenal gland and paraganglia
Adrenocortical carcinoma
Staging of adrenocortical carcinoma

Author: Debra Zynger, M.D. (see Authors page)

Revised: 6 February 2018, last major update January 2018

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Staging of adrenocortical carcinoma[TI]

Cite this page: Zynger, D. Staging of adrenocortical carcinoma. website. Accessed February 23rd, 2018.

Pathologic TNM staging of adrenal cortical carcinoma, AJCC 8th edition
Primary tumor (pT)
  • pTX: Cannot be assessed
  • pT0: No evidence of primary tumor
  • pT1: Tumor ≤ 5 cm, no extra-adrenal invasion
  • pT2: Tumor > 5 cm, no extra-adrenal invasion
  • pT3: Extra-adrenal invasion but no invasion of adjacent organs
  • pT4: Invasion of kidney, diaphragm, pancreas, spleen, liver, renal vein or vena cava
Regional lymph nodes (pN)
  • pNX: Cannot be assessed
  • pN0: No regional lymph node metastasis
  • pN1: Regional lymph node metastasis (ex: paraaortic, periaortic, retroperitoneal)
Distant metastasis (pM)
  • pM1: Distant metastasis
AJCC prognostic stage groups
Stage group I: T1 N0 M0

Stage group II: T2 N0 M0
Stage group III: T1 - 2 N1 M0
T3 - 4 N0 - 1, X M0
Stage group IV: T1 - 4, X   N0 - 1, X   M1  
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Debra Zynger, M.D.

Extra-adrenal adipose invasion (pT3)

Liver involvement (pT4)