Ampulla of Vater
Carcinoma
Neuroendocrine carcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 23 May 2016, last major update August 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Neuroendocrine carcinoma[title]
Definition / General
Case Reports
Micro Description
    Large cell tumor:
  • Islands and trabeculae of large cells with brisk mitotic activity and extensive necrosis
  • Cells have more cytoplasm than small cell carcinoma, irregular chromatin, frequent nucleoli
Micro Images

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Case of the Week #322:


Mixed adenoneuroendocrine carcinoma
Line 2: CDX2 (left); chromogranin (middle); synaptophysin (right)



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Large cell neuroendocrine carcinoma

Small cell neuroendocrine carcinoma

Positive Stains
  • Large cell tumor: cytokeratin, chromogranin, synaptophysin, neuron-specific enolase
Differential Diagnosis
  • Carcinoid
  • Lymphoma
  • Metastases
  • Poorly differentiated carcinoma
  • Small cell carcinoma