Ampulla of Vater
Neuroendocrine carcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 23 May 2016, last major update August 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Neuroendocrine carcinoma[title]
Cite this page: Neuroendocrine carcinoma. website. Accessed October 22nd, 2018.
Definition / general
Case reports
Microscopic (histologic) description
    Large cell tumor:
  • Islands and trabeculae of large cells with brisk mitotic activity and extensive necrosis
  • Cells have more cytoplasm than small cell carcinoma, irregular chromatin, frequent nucleoli
Microscopic (histologic) images

Images hosted on Pathout server:

Case of the Week #322:

Mixed adenoneuroendocrine carcinoma
Line 2: CDX2 (left); chromogranin (middle); synaptophysin (right)

Images hosted on other servers:

Large cell neuroendocrine carcinoma

Small cell neuroendocrine carcinoma

Positive stains
  • Large cell tumor: cytokeratin, chromogranin, synaptophysin, neuron-specific enolase
Differential diagnosis
  • Carcinoid
  • Lymphoma
  • Metastases
  • Poorly differentiated carcinoma
  • Small cell carcinoma