Ampulla of Vater
Neuroendocrine carcinoma

Topic Completed: 1 August 2014

Revised: 27 June 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Neuroendocrine carcinoma[title]

Hanni Gulwani, M.B.B.S.
Page views in 2018: 371
Page views in 2019 to date: 467
Cite this page: Gulwani H. Neuroendocrine carcinoma. website. Accessed December 12th, 2019.
Definition / general
Case reports
Microscopic (histologic) description
    Large cell tumor:
  • Islands and trabeculae of large cells with brisk mitotic activity and extensive necrosis
  • Cells have more cytoplasm than small cell carcinoma, irregular chromatin, frequent nucleoli
Microscopic (histologic) images

Case of the Week #322

Mixed adenoneuroendocrine carcinoma
Line 2: CDX2 (left); chromogranin (middle); synaptophysin (right)

Images hosted on other servers:

Large cell neuroendocrine carcinoma

Small cell neuroendocrine carcinoma

Positive stains
  • Large cell tumor: cytokeratin, chromogranin, synaptophysin, neuron-specific enolase
Differential diagnosis
  • Carcinoid
  • Lymphoma
  • Metastases
  • Poorly differentiated carcinoma
  • Small cell carcinoma
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