Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Ampulla of Vater

Other malignancies

Carcinoid


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 1 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● 3% of ampullary tumors
● Patients typically present with jaundice
● Compared to duodenal carcinoids (which are usually benign), are more aggressive with shorter survival (may die within 1 year), have more metastases
● Somatostatin producing tumors are common, have a glandular pattern, are associated with psammoma bodies and neurofibromatosis, have 50-70% nodal metastases (Am J Clin Pathol 1991;95:51, Am J Clin Pathol 1983;80:755, Am J Clin Pathol 1992;97:411, Am J Surg Pathol 1989;13:828)

Case reports
=========================================================================

● 52 year old Chinese woman with inflammatory pseudotumor associated with periampullary carcinoid (Singapore Med J 2009;50:e100)

Micro description
=========================================================================

● Classic features of carcinoid tumors; somatostatin producing tumors are often mucin+

Micro images
=========================================================================



Monotonous tumor cells with small round nuclei plus various images

Positive stains
=========================================================================

● Chromogranin (60%), synaptophysin (60%), gastrin (20% vs. 75% of duodenal carcinoids, Hum Pathol 2001;32:1252)
● Also somatostatin and pancreatic polypeptide

Differential diagnosis
=========================================================================

● Adenocarcinoma

Additional references
=========================================================================

Arch Pathol Lab Med 2010;134:181-CAP protocol for examination of carcinoid tumors

End of Ampulla of Vater > Other malignancies > Carcinoid


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).