Ampulla of Vater
Frozen section

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 24 February 2016, last major update December 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Frozen section[title]
Table of Contents
Definition / general
Cite this page: Frozen section. website. Accessed June 19th, 2018.
Definition / general
  • Major criteria for malignancy are nuclear size variation of at least 4:1 between ductal epithelial cells, incomplete ductal lumens, disorganized duct distribution
  • Minor criteria are huge, irregular epithelial nucleoli, necrotic glandular debris, glandular mitoses, glands unaccompanied by connective tissue stroma within smooth muscle bundles, perineural invasion (Am J Surg Pathol 1981;5:179)