Cite this page: Gulwani H. Intra-ampullary papillary-tubular neoplasm (IAPN). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ampullaiapn.html. Accessed May 26th, 2020.
Definition / general
- First described in 2010 (Am J Surg Pathol 2010;34:1731)
- Highly analogous to pancreatic or biliary intraductal tubulopapillary neoplasm, with variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence)
- Biologically indolent
- Noninvasive examples have excellent prognosis, invasive tumors have better prognosis than other ampullary malignancies
- 28% of ampillary carcinomas arise in association with IAPNs