Ampulla of Vater
Premalignant / noninvasive
Intra-ampullary papillary-tubular neoplasm (IAPN)

Topic Completed: 1 December 2012

Revised: 8 January 2019

Copyright: (c) 2003-2019,, Inc.

PubMed Search: IAPN
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Cite this page: Gulwani H. Intra-ampullary papillary-tubular neoplasm (IAPN). website. Accessed May 21st, 2019.
Definition / general
  • First described in 2010 (Am J Surg Pathol 2010;34:1731)
  • Highly analogous to pancreatic or biliary intraductal tubulopapillary neoplasm, with variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence)
  • Biologically indolent
  • Noninvasive examples have excellent prognosis, invasive tumors have better prognosis than other ampullary malignancies
  • 28% of ampillary carcinomas arise in association with IAPNs
Microscopic (histologic) images

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