Ampulla of Vater
Premalignant / noninvasive
Intra-ampullary papillary-tubular neoplasm (IAPN)
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● First described in 2010 (Am J Surg Pathol 2010;34:1731)
● Highly analogous to pancreatic or biliary intraductal tubulopapillary neoplasm, with variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence)
● Biologically indolent
● Noninvasive examples have excellent prognosis, invasive tumors have better prognosis than other ampullary malignancies
● 28% of ampillary carcinomas arise in association with IAPNs
End of Ampulla of Vater > Premalignant / noninvasive > Intra-ampullary papillary-tubular neoplasm (IAPN)
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