Ampulla of Vater - Mixed acinar-endocrine carcinoma

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Ampulla of Vater

Carcinoma

Mixed acinar-endocrine carcinoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● May arise in heterotopic pancreatic cells
● Acinar cell carcinoma component is composed of pancreatic acinar cells with zymogen granules on EM

Case reports
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● 47 year old man with neurofibromatosis-1, ampullary somatostatinomas and jejunal gastrointestinal stromal tumor (World J Gastroenterol 2007;13:2761)
● 49 year old woman with neurofibromatosis-1 and mixed endocrine somatostatinoma (JOP 2010;11:64)
● 78 year old man (Hum Pathol 2002;33:449)

Micro description
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● Nests of tumor cells with acinar structures and endocrine immunoreactivity and endocrine granules on EM

Micro images
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Various images

Positive stains
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● Amylase, trypsin, synaptophysin

Electron microscopy description
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● Endocrine and zymogen granules

End of Ampulla of Vater > Carcinoma > Mixed acinar-endocrine carcinoma

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