Ampulla of Vater
Mixed acinar-endocrine carcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 5 February 2016, last major update December 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Mixed acinar-endocrine carcinoma
Definition / General
  • May arise in heterotopic pancreatic cells
  • Acinar cell carcinoma component is composed of pancreatic acinar cells with zymogen granules on EM
Case Reports
Micro Description
  • Nests of tumor cells with acinar structures and endocrine immunoreactivity and endocrine granules on EM
Micro Images

Various images

Positive Stains
  • Amylase, trypsin, synaptophysin
Electron Microscopy Description
  • Endocrine and zymogen granules