Ampulla of Vater
Neuroendocrine tumors - staging

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 2 March 2016, last major update December 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Neuroendocrine tumors staging[title]
Cite this page: Neuroendocrine tumors staging. website. Accessed October 25th, 2016.
Staging / Staging classifications

Primary tumor (T)
    TX: Primary tumor cannot be assessed
    T0: No evidence of primary tumor
    T1: Tumor invades lamina propria or submucosa and tumor size 1 cm or less
    T2: Tumor invades muscularis propria or tumor size >1 cm
    T3: Tumor invades through the muscularis propria into pancreas or retroperitoneum (ampullary or duodenal tumors) or into nonperitonealized tissues
    T4: Tumor invades visceral peritoneum (serosa) or invades other organs

  • For any T, add (m) for multiple tumors

Regional lymph nodes (N)
    NX: Regional lymph nodes cannot be assessed
    N0: No regional lymph node metastasis
    N1: Regional lymph node metastasis

Distant Metastasis (M)
    M0: No distant metastasis
    M1: Distant metastasis

Anatomic stage / prognostic groups
    Stage I: T1 N0 M0
    Stage IIA: T2 N0 M0
    Stage IIB: T3 N0 M0
    Stage IIIA: T4 N0 M0
    Stage IIIB: Any T N1 M0
    Stage IV: M1 (any T, any N)