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Anus and perianal area

Other malignancies

Gastrointestinal stromal tumor


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Anorectal GISTS usually occur in men (70%), age 40+
● Small asymptomatic intramural nodules to large masses that bulge into pelvis causing pain, rectal bleeding or obstruction
● May have late recurrence and distant metastases to liver, bone, lungs

Clinical features
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● Not all anorectal, mural-based stromal neoplasms are malignant (Hum Pathol 1992;23:762)
● Recurrence and metastasis may not appear until several years after treatment (Am J Surg Pathol 1999;23:946)

Prognostic factors
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● Poor prognostic factors: size > 5 cm with 5+ mitotic figures/50 HPF (Am J Surg Pathol 2001;25:1121)

Micro description
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● Usually highly cellular spindle cell tumors
● Occasionally epithelioid morphology

Positive stains
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● CD117, CD34

Negative stains
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● Smooth muscle actin (usually), desmin (usually), S100

End of Anus and perianal area > Other malignancies > Gastrointestinal stromal tumor


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