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Anus and perianal area

Carcinoma

Highly differentiated squamous lesion


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Highly differentiated squamous lesion that appears to be invasive
● Composed of large, mature squamous cells except at base and edges, which have more undifferentiated cells with mitotic activity
● Epithelium is acanthotic and hyperkeratotic; lamina propria has lymphoplasmacytic infiltrate
● May be invasive, but local excision appears to be curative

End of Anus and perianal area > Carcinoma > Highly differentiated squamous lesion


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