Anus & perianal
Highly differentiated squamous lesion

Topic Completed: 1 April 2005

Revised: 20 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Highly differentiated squamous lesion perianal

Nat Pernick, M.D.
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Page views in 2019 to date: 272
Table of Contents
Definition / general
Cite this page: Pernick N. Highly differentiated squamous lesion. website. Accessed October 19th, 2019.
Definition / general
  • Highly differentiated squamous lesion that appears to be invasive
  • Composed of large, mature squamous cells except at base and edges, which have more undifferentiated cells with mitotic activity
  • Epithelium is acanthotic and hyperkeratotic; lamina propria has lymphoplasmacytic infiltrate
  • May be invasive but local excision appears to be curative
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