Anus and perianal area
Highly differentiated squamous lesion

Author: Nat Pernick, M.D. (see Authors page)

Revised: 9 October 2017, last major update April 2005

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Highly differentiated squamous lesion perianal

Table of Contents
Definition / general
Cite this page: Pernick, N. Highly differentiated squamous lesion. website. Accessed May 21st, 2018.
Definition / general
  • Highly differentiated squamous lesion that appears to be invasive
  • Composed of large, mature squamous cells except at base and edges, which have more undifferentiated cells with mitotic activity
  • Epithelium is acanthotic and hyperkeratotic; lamina propria has lymphoplasmacytic infiltrate
  • May be invasive but local excision appears to be curative