Anus and perianal area
Benign or non-neoplastic lesions
Internal anal sphincter achalasia
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Similar presentation to Hirschsprung’s disease, but ganglion cells are present on rectal biopsy
● Anorectal manometry shows absence of rectosphincteric reflex on balloon inflation
● Marked reduction or absence of interstitial cells of Cajal in internal anal sphincter in these patients (Arch Pathol Lab Med 2003;127:1192)
Reduction of nerve fibers and interstitial cells of Cajal in internal anal sphincter (figures 1B, 2B)
End of Anus and perianal area > Benign or non-neoplastic lesions > Internal anal sphincter achalasia
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