Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Anus and perianal area

Other malignancies

Leiomyosarcoma


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Most common stromal tumor of anus
● Usually forms polypoid intraluminal mass; may be confused with a hemorrhoid
● Often women, median age 58 years (range 24-79 years)
● Presents with rectal obstruction or bleeding
● Most do not die of disease (Am J Surg Pathol 2001;25:1121)

Gross description
=========================================================================

● Median 3 cm (range 2 to 5.5 cm)
● Usually polypoid, ulcerated, intraluminal masses

Micro description
=========================================================================

● Spindle cell tumors, usually resembling well differentiated smooth muscle cells
● Oval to moderated elongated, often blunt-ended, with distinctly eosinophilic cytoplasm, atypical nuclei, focal nuclear pleomorphism
● Usually mucosal ulceration
● High mitotic activity in all cases (26+ mitotic figures/10 HPF)

Positive stains
=========================================================================

● Actin

Negative stains
=========================================================================

● CD117

End of Anus and perianal area > Other malignancies > Leiomyosarcoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).