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Anus and perianal area

Inflammatory diseases


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 14 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Abnormal tract that opens within anal canal, usually at or above dentate line
● Usually leads to skin, may end blindly in perianal soft tissue
● Usually caused by abscess in anal duct
● May be associated with Crohn’s disease (complex fistulas with irregular edges), ulcerative colitis, actinomycosis, tuberculosis (lung disease usually present)

Micro description

● Tract lined by granulation tissue with acute and chronic inflammation, giant cells, variable granulomas
● May epithelialize

End of Anus and perianal area > Inflammatory diseases > Fistula

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