Anus and perianal area
Benign or non-neoplastic lesions
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Absence of ganglion cells in distal bowel extending proximally for varying distances (note: ganglion cells are usually absent or sparse in anorectal wall for 1-2 cm above dentate line)
● Marked reduction or absence of interstitial cells of Cajal in internal anal sphincter in these patients (Arch Pathol Lab Med 2003;127:1192)
Reduction of nerve fibers and interstitial cells of Cajal in internal anal sphincter (figures 1C, 2C)
End of Anus and perianal area > Benign or non-neoplastic lesions > Hirschsprung’s disease
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