Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Anus and perianal area

Benign or non-neoplastic lesions

Hirschsprung’s disease


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Absence of ganglion cells in distal bowel extending proximally for varying distances (note: ganglion cells are usually absent or sparse in anorectal wall for 1-2 cm above dentate line)
● Marked reduction or absence of interstitial cells of Cajal in internal anal sphincter in these patients (Arch Pathol Lab Med 2003;127:1192)

Micro images
=========================================================================



Reduction of nerve fibers and interstitial cells of Cajal in internal anal sphincter (figures 1C, 2C)

End of Anus and perianal area > Benign or non-neoplastic lesions > Hirschsprung’s disease


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).