Anus and perianal area
Benign or nonneoplastic lesions
Inflammatory cloacogenic polyp

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 3 October 2017, last major update November 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Inflammatory cloacogenic polyp

Cite this page: Weisenberg, E. Inflammatory cloacogenic polyp. website. Accessed May 21st, 2018.
Definition / general
  • Middle aged patients with rectal bleeding
  • Single or multiple polyps in anal canal, resemble hemorrhoids
  • Associated with solitary rectal ulcer syndrome or mucosal prolapse; may be due to prolapse with ischemic damage and subsequent repair
  • Patients may also have HPV related disorders
  • Excision
Gross description
  • Sessile, 1 - 2 cm
Microscopic (histologic) description
  • Tubulovillous with elongated, irregular crypts extending into submucosa (resembles colitis cystica profunda)
  • Squamous, colorectal or transitional epithelium, eroded at surface or covered with exudate (Am J Surg Pathol 1981;5:761)
  • May be hyperplastic or regenerative
  • Thickened muscularis mucosa with irregular strands penetrating lamina propria
  • No dysplastic changes, no desmoplasia, no invasion
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Yvonne Bury, University Hospital of North Durham (UK)

Images hosted on other servers:

Low power

Left: H&E, right: PCNA

Differential diagnosis